scholarly journals Assessment of Density of Neovascularization in Lower Lip Squamous Cell Carcinoma in Relation To Neoplasm Differentiation Grade in Patients with and without Neck Lymph Nodes Metastasis

2019 ◽  
Vol 7 (1) ◽  
pp. 19-23
Author(s):  
Lena Kakasheva-Mazhenkovska ◽  
Marko Kostovski ◽  
Gjorgje Gjokik ◽  
Vesna Janevska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Tumour Progression ◽  
Regional Lymph Nodes ◽  
Lower Lip ◽  
Neck Metastasis ◽  
Significant Difference

BACKGROUND: Squamous cell carcinoma (SCC) of the lower lip is a relatively rare carcinoma, with the incidence of 1 to 2%, but it is the most common carcinoma in the oral cavity accounting for 25-30% of all malignant oral tumours. AIM: This study aimed to determine the role of neovascularisation in the process of tumour progression. METHODS: We analysed the surgical specimens obtained from 60 patients with squamous cell carcinoma (SCC) of the lower lip. The examined group consisted of 45 specimens of patients without metastasis and 15 specimens of patients with metastasis in the regional lymph nodes. Histopathological slides were immunohistochemically stained with an antibody against CD34 and by hematoxylin & eosin staining for routine histopathological examination. RESULTS: The results obtained showed a statistically significant difference in the density of neovascularisation between groups of the SCC with different grade of differentiation (Kruskal-Wallis test: H (2, N = 60) = 30.0943, p = 0.00001). Statistical analysis also showed a significant difference in the density of vascularisation of lower lip SCC between patients without metastasis and patients with neck metastasis (Mann-Whitney U test, p = 0.000198). Applying Pearson’s chi-square test, we found a highly significant statistical difference in grade of SCC differentiation in patients with and without neck metastasis (p = 0.0000). CONCLUSION: In conclusion, the density of neoangiogenesis is increased in tumours with poorer differentiation and in patients with neck metastasis. So, the density of neovascularisation of the primary lip SCC may predict the tumour progression.

Squamous Cell Carcinoma of the Penis. III. Treatment of Regional Lymph Nodes

1993 ◽  
Vol 149 (3) ◽  
pp. 492-497 ◽  
Author(s):  
Simon Horenblas ◽  
Harm van Tinteren ◽  
Jan F.M. Delemarre ◽  
Luc M.F. Moonen ◽  
Vera Lustig ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Regional Lymph Nodes

Role of Suprahyoid Neck Dissection in the Treatment of Squamous Cell Carcinoma of the Lower Lip

1997 ◽  
Vol 106 (9) ◽  
pp. 787-789 ◽  
Author(s):  
Can Koç ◽  
M. Umut Akyol ◽  
Ali Çekiç ◽  
Serdar Çelikkanat ◽  
Cafer Özdem
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Radical Neck Dissection ◽  
Occult Metastasis ◽  
Cervical Lymph Nodes ◽  
Lower Lip ◽  
Occult Metastases

Treatment of squamous cell carcinoma of the lip is primarily surgical. Unlike other oral lesions, lower lip cancers do not metastasize to lower cervical lymph nodes without invading submental and submandibular lymph nodes. This study presents 30 patients with NO lower lip carcinoma who were treated by en bloc resection of the tumor with suprahyoid neck dissection. Occult metastasis was found in 4 patients (13%). Four patients, 3 of whom had no occult metastases, died of local or regional uncontrollable disease. Suprahyoid or modified radical neck dissection appears to be beneficial, even in small tumors of the lower lip, in detecting occult metastases.

Immunologic patterns of regional lymph nodes in squamous cell carcinoma of the floor of the mouth

1985 ◽  
Vol 150 (4) ◽  
pp. 461-465 ◽  
Author(s):  
Alejandro H. Ring ◽  
Kumao Sako ◽  
Uma Rao ◽  
Mohamed S. Razack ◽  
Peter Reese
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Regional Lymph Nodes ◽  
Floor Of The Mouth

Early stage squamous cell carcinoma of the lower lip: predictive factors for recurrence

2016 ◽  
Vol 130 (4) ◽  
pp. 369-372 ◽  
Author(s):  
Y Ozkul ◽  
M Songu ◽  
A Imre ◽  
E Tunc ◽  
Z Ozkul ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Local Recurrence ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Clinicopathological Parameters ◽  
Lower Lip ◽  
Neck Metastasis ◽  
Tumour Thickness

AbstractObjective:This study aimed to evaluate the effect of tumour thickness on other clinicopathological parameters in early stage lower lip squamous cell carcinoma.Methods:Forty-six consecutive patients with lower lip squamous cell carcinoma were included in the study. Demographic, clinical and pathological data were retrospectively collected.Results:The mean follow-up period for all patients was 32.0 ± 18.9 months. Forty-four tumours were staged as T1 and two were T2. Twelve patients underwent neck dissection. Two patients presented with neck metastasis in the follow-up period. Four patients (8.7 per cent) had local recurrence. Correlation analysis revealed a significant relationship between microscopic tumour thickness and local tumour recurrence (r = 0.328, p = 0.045).Conclusion:Surgical margin control is important to prevent local recurrence, especially in thicker tumours. In addition, neck metastasis is rare in early stage lower lip squamous cell carcinoma. A ‘wait and see’ policy might be preferred in early stage T1 lower lip squamous cell carcinoma cases.

Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes

2001 ◽  
Vol 45 (5) ◽  
pp. 767-770 ◽  
Author(s):  
Makoto Inaoki ◽  
Kenzo Kaji ◽  
Shinobu Furuse ◽  
Akihide Fujimoto ◽  
Nahoko Komatsu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Pemphigus Foliaceus ◽  
Regional Lymph Nodes
Sign in / Sign up

Export Citation Format

Share Document