scholarly journals Патоморфологічна характеристика хламідіозу в котів

2017 ◽  
Vol 19 (77) ◽  
pp. 11-14
Author(s):  
V. Lisova ◽  
A. Savchenko
Keyword(s):  
Lymph Nodes ◽  
Chlamydial Infection ◽  
Historical Data ◽  
Underlying Disease ◽  
Regional Lymph Nodes ◽  
Laboratory Methods ◽  
Main Research ◽  
Pathological Material ◽  
The Right ◽  
Lymphoid Nodules

The results of the study of the morphological features of pathological processes in organs and tissues of dead cats from chlamydial infection. A study of cadavers (n = 8), cats of different breeds aged from 3 to 6 years old, who lives with the laboratory methods have been diagnosed and identified the pathogen Chlamydia felis. According to historical data from sick animals were recorded various nature and degree of conjunctivitis and pronounced signs of a lesion of the respiratory tract (rhinitis, bronchitis, pneumonia). The main research method was mortem examination, during which the fixed and described the macroscopic changes in the affected organs and tissues. The autopsy was carried out partial evisceration, while selected pathological material for further histological studies. It is shown that the most pronounced damage and characteristic macroscopic changes all dead cats fixed contact in lung tissues and regional lymph nodes (mediastinal and bronchial), and in the spleen. Macroscopic picture of lungs affected varied somewhat depending on the degree of damage and stages of morphogenesis. In most cases (n = 6) lesions in the lungs looked like multiple well-defined lesions that are localized in all lobes of the lungs. Morphological manifestations of chlamydial infection in the investigated dead cats on the macroscopic level following features are: 1) productive inflammation in the lungs in a subtotal and total interstitial pneumonia and pulmonary fibrosis; 2) catarrhal bronchitis; 3) hyperplasia and serous lymphadenitis of the mediastinal and bronchial lymph nodes; 4) hyperplasia of lymphoid nodules of the spleen; 5) serous conjunctivitis. Also, a disease accompanied by nonspecific general pathological processes, such as: passive venous congestion of the liver and kidneys; degenerative changes in the liver; dilation of the right ventricle of the heart, which occurs as a complication of the underlying disease. While studies of other organs and tissues of dead animals we have not found any macroscopic changes.

scholarly journals Патоморфологічна характеристика коронавірусної інфекції в собак

2017 ◽  
Vol 19 (77) ◽  
pp. 7-10
Author(s):  
V. Lisova ◽  
O. Dubinenko
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Polymerase Chain Reaction Analysis ◽  
Underlying Disease ◽  
Left Ventricular ◽  
Morphological Features ◽  
Mesenteric Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Coronavirus Infection ◽  
Pathological Material

The results of the study of the morphological features of pathological processes in organs and tissues of dogs with coronavirus infection. The study of cadavers (n = 3) dogs of different breeds and sex between the ages of 2 to 6 months, who died with diarrheal syndrome. Presence of coronavirus, without other assiociants, in these cases had previously been confirmed in the polymerase chain reaction analysis of fecal samples. At this stage, the main method of our study was mortem autopsy. At autopsy, which was carried out in partial evisceration, recorded and described the macroscopic changes identified in various tissues and organs of dead dogs and selected pathological material for subsequent histological examination. It is shown that the most pronounced lesions and typical change in all dead dogs fixed contact in the small intestine (jejunum and to the ileum) and the regional lymph nodes to it, as well as in the spleen. It is shown that the morphological manifestations of coronavirus infection in dogs following features are on the macroscopic level: the presence of exudative inflammation in the small intestine in the form serous-fibrinous jejuno-ileitis; hyperplasia and serous-hemorrhagic lymphadenitis mesenteric lymph nodes; multiple foci of hemorrhage of different character (spotted and striped) in the parenchyma of the spleen and serous membrane of the small intestine; dilatation of the right ventricle of the heart; cachexy and dehydration due to diarrheal syndrome. Also, non-specific, but constant morphological features, which arose as a result of circulatory disorders and heart failure were: passive venous congestion of the liver, kidney and pulmonary edema; degenerative processes in the liver. In one case, we identified morphological features characteristic of serous-inflammatory swelling of the pancreas and pathological changes in the myocardium that are typical of concentric hypertrophy of left ventricular heart. These pathological processes can be considered a complication that developed as a result of the underlying disease.

scholarly journals Transcoelomic and Lympho-Hematogenous Dissemination of Endometrioid Heterotopias – the Mechanism of Extragenital Endometriosis Formation

2021 ◽  
Vol 10 (1) ◽  
pp. 85-91
Author(s):  
R. V. Ukrainets ◽  
Yu. S. Korneva
Keyword(s):  
Lymph Nodes ◽  
Vena Cava ◽  
The Body ◽  
Lung Damage ◽  
Pelvic Cavity ◽  
Regional Lymph Nodes ◽  
Normal Endometrium ◽  
Pulmonary Endometriosis ◽  
Extragenital Endometriosis ◽  
The Right

Endometriosis nowadays still a disease with an undisclosed pathogenesis. This article demonstrates and explains the possibility of different variants of dissemination of endometrioid cells in the body with the formation of foci of extragenital endometriosis in organs and tissues remote from the pelvis, complementing and confirming the theory of utero-peritoneal reflux in the development of endometriosis as the most reasonable. Endometrioid heterotopias have a more developed lymphatic network compared to the normal endometrium due to active lymphangiogenesis, and, having a tendency to invasive growth, endometrioid heterotopia is a source of endometrioid cells spreading along the direction of lymph outflow from the most typical locations (pelvic organs) with damage to the inguinal and pelvic lymph nodes. Lymphatic dissemination in adenomyosis is observed in every fourth patient, which requires revision of the surgery protocol with excision of regional lymph nodes to prevent relapses. The presence of cases of pulmonary endometriosis and endometrioid liver cysts makes hematogenic dissemination of endometriosis from the primary source in the pelvic region obvious. The most frequent localizations of endometrioid heterotopias are located near the corresponding venous plexuses of the small pelvis, the outflow from which occurs mainly through the inferior vena cava, without anatomical obstacles for hematogenic dissemination of endometrioid cells with subsequent lung damage. For liver involment, it is likely that endometriosis in the distal parts of the colon is important, the venous outflow from which is directed to the portal vein system. Endometriosis of the diaphragm – is an example transcoelomic spread with predominant location on the right dome of the diaphragm, as the right subphrenic space communicates with the pelvic cavity through the right lateral channel, which justifies the possibility of such involments of the diaphragme in context of the theory of uteroperitoneal reflux.Thus, the theory of menstrual regurgitation and the theory of hemato-lymphatic dissemination are components of a single pathogenetic model of the distribution of endometrioid cells in the body.

scholarly journals Гістологічні зміни в котів за хламідіозу

2017 ◽  
Vol 19 (78) ◽  
pp. 158-161
Author(s):  
V. Lisova ◽  
A. Savchenko
Keyword(s):  
Lymph Nodes ◽  
Interstitial Pneumonia ◽  
Chlamydial Infection ◽  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Bronchial Epithelium ◽  
Histological Structure ◽  
Regional Lymph Nodes ◽  
Morphological Criteria ◽  
Hematoxylin And Eosin

The article presents the results of the study of histological changes in organs and tissues of cats for chlamydial infection. The histopathological examination of the postmortem cases of cats (n = 8) of different breeds between the ages of 3 to 6 years old, who lives with the laboratory methods have been diagnosed and identified the pathogen Chlamydia felis. According to historical data from sick animals were recorded various nature and degree of conjunctivitis and pronounced signs of a lesion of the respiratory tract (rhinitis, bronchitis, pneumonia). The made histological sections were stained with hematoxylin and eosin according to routine standard methods. The general histological structure and microstructural changes in histological preparations were studied under a light microscope. The histopathological examination were confirmed and specified the pathoanatomical diagnoses, established after autopsy of dead animals. It is shown that the most pronounced damage and characteristic changes all dead cats fixed contact in lung tissues and regional lymph nodes (mediastinal and bronchial), and in the spleen. The morphological criteria of chlamydial infection in the studied dead animals at the microscopic level were as follows:1) interstitial pneumonia; 2) pulmonary fibrosis; 3) fibrinous-purulent pleuropneumonia; 4) hyperplasia and serous lymphadenitis of the mediastinal and bronchial lymph nodes; 5) hyperplasia of lymphoid nodules of the spleen; 6) passive venous congestion of the liver and kidneys; 7) fatty and granular liver dystrophy. The results of our study, the pathomorphological diagnosis of chlamydial infection in most of the cats that died was based on changes characteristic of interstitial pneumonia followed pneumosclerosis or fibrinous-purulent pleuropneumonia, with deep affection of the bronchial epithelium. Consequently, the features of chlamydial infection are such that the clinical picture does not always correspond to the severity of morphological manifestations and complications of infection. Weak clinical manifestations can be combined with significant destructive, degenerative and necrotic changes in organs and tissues.

scholarly journals Metastasis of neuroendocrine tumor mimicking primary breast cancer: case report

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Yuki Tany Hirakawa Vieira ◽  
Andre Luiz de Freitas Perina ◽  
Daniela Ferreira Vieira Vendramini ◽  
Thatyanne Cunha Esposito Gallo ◽  
Felipe Eduardo Martins Andrade
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Neuroendocrine Tumor ◽  
Axillary Lymph Node ◽  
Cervical Lymph Node ◽  
Ileocecal Valve ◽  
Axillary Lymph ◽  
Regional Lymph Nodes ◽  
The Right

Introduction: Neuroendocrine tumor has an annual incidence of 2–5 cases/100,000 inhabitants, most of them asymptomatic, and may clinically present as carcinoid syndrome: facial flushing, diarrhea, and bronchospasm. It has a great tendency to metastasize to regional lymph nodes and liver, being unusual in the breast. Clinical case: A black 47-year-old woman without comorbidities presented a nodule with progressive growth for 2 years in the right upper inner quadrant (RUIQ), biopsied and diagnosed as breast cancer, without a specific subtype or immunohistochemistry (IHC). Physical examination revealed a 3 cm nodule, hard and fixed axillary lymph node, and enlarged yet fibroelastic and mobile anterior cervical lymph node. Ultrasound (US) identified two irregular nodules in the RUIQ and the junction of the right outer quadrants (JROQ) measuring 2.5 cm and 0.7 cm, respectively, and level I axillary lymph node with cortical thickening. The JROQ nodule and the axillary lymph node were biopsied. The cervical lymph node did not show loss of hilum or suspicious abnormalities on US and was not biopsied. Anatomopathological results of the nodule were compatible with invasive carcinoma without a specific subtype, with estrogen receptor weakly positive (10%), Ki-67 7%, and negative for other markers. The axillary lymph node was negative for metastasis. During staging, an abdominal computed tomography identified a 1.9 cm lesion of likely neuroendocrine origin in the ileocecal valve with metastasis to the liver, regional lymph nodes, and breast. Complementary IHC of the biopsy slide was later performed with chromogranin, synaptophysin, and CDX-2, and the diagnosis reached was breast metastasis of neuroendocrine tumor. An external review of biopsy slides of the RUIQ nodule was requested, and the patient was referred to the oncology department to continue treatment. Conclusion: Metastasis of gastrointestinal tumors to the breast corresponds to less than 0.5% of cancers, with 15 reports in the literature, of which only 7 were asymptomatic, and their clinical presentation started with breast lesion, as in the case described herein. Given its rarity, as well as the clinical and radiological difficulties in differentiating these lesions, special attention must be paid to differential diagnoses, especially in cases of discrepancies between the tumor histology and IHC or lack of correlation between image and clinical condition.

scholarly journals Гістологічні зміни в собак за коронавірусної інфекції

2017 ◽  
Vol 19 (78) ◽  
pp. 154-157 ◽  
Author(s):  
V. Lisova ◽  
O. Dubinenko
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Histological Study ◽  
Polymerase Chain Reaction Analysis ◽  
Histological Structure ◽  
Mesenteric Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Liver And Kidney ◽  
Coronavirus Infection ◽  
Pathological Material

The article presents the results of the study of histological changes in organs and tissues of dogs for coronavirus infection. The histological study of the pathological material of cadavers (n =5) dogs of different breeds and sex between the ages of 2 to 6 months, who died with diarrheal syndrome. The study of presence of coronavirus, without other assiociants, in these cases had previously been confirmed in the polymerase chain reaction analysis of fecal samples. The made histological sections were stained with hematoxylin and eosin according to standard prescriptions. The general histological structure and microstructural changes in histological preparations were studied under a light microscope. Histological studies have been confirmed and supplemented with pathoanatomical diagnoses, established after autopsies of dead bodies of dead animals. The most pronounced lesions and typical change in all dead dogs fixed contact in the small intestine (jejunum and to the ileum) and the regional lymph nodes to it, as well as in the spleen. It is shown that the morphological manifestations of coronavirus infection in dogs following features are on the microscopic level: the presence of exudative inflammation in the small intestine in the form serous-fibrinous jejuno-ileitis; hyperplasia of single and congested lymphoid nodes of the mucous membrane of the small intestine; hyperplasia and serous-hemorrhagic lymphadenitis mesenteric lymph nodes; foci of hemorrhage and hemorrhagic heart attacks in the spleen parenchyma; hyperplasia lymphoid nodes of the spleen; foci of hemorrhage in the serous membrane of the small intestine. Also, non-specific, but constant morphological features, which arose as a result of circulatory disorders and heart failure were: passive venous congestion of the liver and kidney; degenerative processes in the liver and kidney parenchyma. Consequently, local and general immunological processes develop during the coronaviral infection. Therefore, additional diagnostic markers appear hyperplastic and inflammatory changes of regional seats to the reproduction of the virus lymphoid organs.

scholarly journals Two Cases of Metastases of Carcinoma of the Right-sided Colon to the Gastric Regional Lymph Nodes

2014 ◽  
Vol 67 (3) ◽  
pp. 173-177 ◽  
Author(s):  
Masato Nakano ◽  
Yasumasa Takii ◽  
Satoshi Maruyama ◽  
Mao Nakayama ◽  
Masato Fukumoto
Keyword(s):  
Lymph Nodes ◽  
Regional Lymph Nodes ◽  
The Right

Is splenectomy for dissecting splenic hilar lymph nodes justified in scirrhous type of gastric cancer?

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 359-359
Author(s):  
Tsutomu Hayashi ◽  
Takaki Yoshikawa ◽  
Ayako Kamiya ◽  
Keichi Date ◽  
Takeyuki Wada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Survival Benefit ◽  
Splenic Artery ◽  
Cancer Center ◽  
High Morbidity ◽  
Gastric Artery ◽  
Regional Lymph Nodes ◽  
Metastatic Rate ◽  
The Right

359 Background: Splenectomy for dissecting splenic hilar nodes (#10) should be avoided for most gastric cancer considering high morbidity and no survival benefit, while that is often selected in scirrhous type of gastric cancer because this special type frequently invades the whole stomach and the #10 nodes. Splenectomy is necessary for dissecting #10, however, survival benefit of dissecting #10 is unclear. Methods: Patients who had scirrhous gastric cancer and underwent D2 total gastrectomy with splenectomy in National Cancer Center Hospital, Japan, between 2000 to 2011 were retrospectively analyzed. The therapeutic value index was calculated by multiplying the metastatic rate of each nodal station and the 5-year survival of patients who had metastasis to each node. Results: In total, 144 patients were eligible for the present study. The most frequent metastatic site was the nodes along the lessar curvature (#3, 57%), followed by the nodes along the right gastro-epiploic artery (#4d, 45%), the right nodes located at the cardia (#1, 34%), the nodes along the left gastro-epiploic artery (#4sb, 23%), the inferior nodes at the pyloric ring (#6, 22%), the nodes along the left gastric artery (#7, 21%), the nodes along the short gastric artery (#4sa, 18%), the nodes along the cardiac branched artery (#2, 15%), the nodes around the spleen (#10, 15%), the distal nodes along the splenic artery (#11d, 15%), the proximal nodes along the splenic artery (#11p, 13%), the nodes around the celiac artery (#9, 13%), and the nodes along the common hepatic artery (#8a, 10%). These lymph nodes had a metastatic rate of more than 10%. The node with the highest index was #3(18), followed by #4d(13.4), #1(9.59), #4sa(5.85), #4sb(5.75), #10(4.86), #7(4.16), #11d(4.16), #11p(3.87), #2(3.07), #8a(2.08), and #9(1.39). The index of #10 was exceeded that of #2, #7, #8a, and #9 which are the key nodes dissected in D2. Conclusions: The metastatic rate of splenic hilar nodes was relatively high, and the therapeutic index was the sixth highest in the fifteen regional lymph nodes included in D2 dissection. Splenectomy for dissecting splenic hilar nodes would be justified in scirrhous type of gastric cancer considering its survival benefit.

Disseminated Malignant Histiocytosis in a Golden Retriever: Clinicopathologic, Ultrastructural, and Immunohistochemical Findings

1993 ◽  
Vol 30 (3) ◽  
pp. 256-264 ◽  
Author(s):  
D. W. Hayden ◽  
D. J. Waters ◽  
B. A. Burke ◽  
J. C. Manivel
Keyword(s):  
Lymph Nodes ◽  
Tumor Cells ◽  
Mononuclear Cells ◽  
Lectin Binding ◽  
Periodic Acid ◽  
Golden Retriever ◽  
Malignant Histiocytosis ◽  
Regional Lymph Nodes ◽  
Human T Cell ◽  
The Right

Diagnosis of malignant histiocytosis (MH), a disorder characterized by systemic proliferation of morphologically atypical histiocytes and their precursors, in an 8-year-old neutered female Golden Retriever was based on light and electron microscopic and immunohistochemical findings. Clinically, the dog presented with unilateral forelimb lameness. Eight days after surgical exploration of a swollen brachium, the dog developed sudden onset of posterior paresis, fecal and urinary incontinence, and a flaccid tail. Necropsy revealed infiltrative and nodular lesions in the right forelimb and regional lymph nodes, thoracic and abdominal cavities, and lumbar epidural space. Gross lesions were not found in the lungs or integument. Histopathologic examination showed infiltrates of atypical histiocytes in skeletal muscle, joint, and regional lymph nodes of the right forelimb; intercostal muscle; lung; liver; spleen; pancreas; kidneys; and spinal dura. Most tumor infiltrates were nodular and composed of loosely aggregated cells that were 10-30 μm in diameter with abundant eosinophilic to foamy cytoplasm, had central or eccentric nuclei, and were periodic acid-Schiff negative. Many binucleated cells, multinucleated giant cells, and mitotic figures were seen. Tumor cells contained phagocytosed erythrocytes, mononuclear cells, and some leukocytes. Ultrastructural features of tumor cells included cytoplasmic lipid droplets, lysosomes, and phagolysosomes. Immunohistochemical studies on paraffin-embedded sections showed positive reactivity to human T-cell Ag (clone UCHL-1) and for lysozyme, α-1-antitrypsin, and cathespin B. Polyclonal intracellular immunoglobulin reactivity and lectin binding (peanut, soybean, and wheat germ agglutinins and concanavalin A) were also demonstrated. Criteria for diagnosis of malignant histiocytic tumors and differential diagnosis are discussed.

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