scholarly journals The use of GnRH agonist for supression of cats reproductive function

2017 ◽  
Vol 19 (73) ◽  
pp. 25-27
Author(s):  
A.I. Vasetska ◽  
A.A. Mass

The article presents the results concerning the duration of GnRH agonist deslorelin «Suprelorin» 4.7 mg using in cats prepubertal and pubertal age. Experiments conducted on pedigree and non-pedigree cats and lasting for 2.5 years. For research was formed three groups (n = 10), age from 3 months to 3 years. The first group was the control animals, they flowed naturally estrus cycle, they received any drugs and have no contact with male. The estrus cycle of the control group of animals observed an average six times within one year, three times in spring and autumn, which is the norm for this type of animal. For 30 months (2.5 years) observation cats from the control group showed excitement stage of estrus cycle an average 15 times. Animals from the second group, age 3–6 months, which has not have the first estrus (prepubertal) was placed subcutaneous implant «Suprelorin» 4.7 mg. In the third group were cats from 7 months to 3 years which have experienced one or more estrus cycles (pubertal). The animals were implanted implant «Suprelorin» 4.7 mg immediately after the last estrus. In the second group of animals (prepubertal), excitement stage of reproductive cycle manifested through 480–1567 days after implant implanted and the average duration of the reproductive cycle was 920 days (30 months). A few cats from this group were found changes in the reproductive system such as: uneven structure of the endometrium, reducing the size of the ovaries, ovarian cysts after ovariohysterectomy. Cats from the third group (pubertal) excitement stage of reproductive cycle manifested after 120 to 730 days after implanted the GnRH implant and the average duration of the reproductive cycle was 379 days (approximately 13 months). A few cats from this group, after ovariohysterectomy, observed changes in the reproductive system such as: endometrial hyperplasia, uneven structure and porosity consistency endometrial, ovarian cyst.

Author(s):  
О.В. ЛАТЫШЕВА ◽  
А.В. ИВАНОВ

Изучено влияние на репродуктивную функцию коров белково-витаминно-минеральных концентратов (БВМК) с кормовой добавкой «AMG-COMPLEX», состоящей из эфирных масел и растительных экстрактов. Для проведения опыта были сформированы контрольная и опытная группы по 70 голов с учетом количества дней до отела из коров второй и третьей стельности. Животным контрольной группы скармливали основной рацион. Для коров опытной группы были составлены рационы с БВМК, которыми заменяли пропорциональное количество концентрированных кормов и часть витаминно-минерального премикса. Они получали БВМК для сухостойных коров в количестве 300 г на 1 голову в сутки с 60-го по 20-й день до отела и по 200 г на 1 голову в сутки с 20-го дня до отела. После отела 60 дней им скармливали БВМК для раздоя в количестве 1200 г на 1 голову в сутки. Использование БВМК в рационах коров опытной группы способствовало улучшению у них репродуктивной функции и снижению частоты гинекологических заболеваний после отела в 4,5 раза. Индекс осеменения в опытной группе составил 1,73 (P≤0,05), что на 0,76 ниже, чем у животных контрольной группы. Средняя продолжительность сервис-периода в опытной группе составила 87,71 дня (P≤0,01) и была короче, чем в контроле, на 14,72 дня. The effect on the reproductive function of cows of the protein-vitamin-mineral concentrate with the feed additive ʺAMG-COMPLEXʺ, consisting of essential oils and plant extracts, was studied. To experiment, taking into account the number of days before calving, control and experimental group of 70 heads each were formed from cows of the second and third pregnancy. In the scientific and economic experiment, the cows of the control group consumed the feed of the main rations. For the cows of the experimental group rations were made with PVMC, which replaced the proportional amount of concentrated feed and a part of the vitamin-mineral premix. They received PVMC deadwood in the amount of 300 g per 1 head per day from 60th to 20th day before calving and 200 g per 1 head per day 20 days before calving. 60 days after calving they received PVMC lactation in the amount of 1200 g per head per day. Feeding PVMC to cows of the experimental group contributed to the improvement of reproductive function and a decrease in the frequency of gynaecological diseases after calving by 4.5 times. The insemination index in the experimental group was 1.73 (P≤0.05), which is 0.76 lower than in the animals in the control group. The average duration of the service period in the experimental group was 87.71 days (P≤0.01) and was shorter than in the control by 14.72 days.


2017 ◽  
Vol 3 (6) ◽  
pp. 765-770
Author(s):  
Iin Wahyuni ◽  
Noor Pramono ◽  
Titi Suherni ◽  
Melyana Nurul Widyawati

Objective: This study aimed to examine the pregnancy exercise during the third trimester of pregnancy on duration of the first and second stage of labor in primigravida at the Community Health Center of Sukamaju, Bandar lampung, Indonesia.Methods: This study employed a quasy experimental design with posttest-only non-equivalent control group. This study was conducted from 8 January 2017 to 12 February 2017 at the Community Health Center of Sukamaju. Forty-eight primigravida mothers were selected using consecutive sampling, with 24 assigned in the experiment and control group. Data were analyzed using Mann whitney and Chi square test.Results: The average duration of the first stage of labor in the experiment group was 495 minutes and in the control group was 685 minutes (p= 0.000); while the average duration of the second stage of labor in the experiment group was 42.5 minutes and in the control group was 68.75 minutes (p=0.000).Conclusion: There was a statistically significant difference in the duration of the first and second stage of labor between experiment and control group. It is expected for midwives in the community health centers to implement pregnancy exercise program to help mothers in accelerating the delivery process.


2011 ◽  
Vol 11 ◽  
pp. 2613-2619 ◽  
Author(s):  
Iman K. Behiry ◽  
Emad A. Abada ◽  
Entsar A. Ahmed ◽  
Rania S. Labeeb

In this study we isolate and identify the EnteropathogenicEscherichia coli(EPEC) causing diarrhea in children less than five years in Cairo, Egypt, during different seasons. Children younger than five years with diarrhea, attending the Pediatric Gastroenterology Intensive Care Unit of the Cairo University Pediatric Hospital in one year period were our group of study. Our control group was age and sex matched concurrent healthy children. The identifiedE. coliisolates were subjected to antimicrobial disc diffusion susceptibility test and further identified for EPEC serotype by slide agglutination test, using antiserumE. colisomatic trivalent I (O111, O55, O26) according to the instructions of the manufacturer. Out of 134 patients 5.2% of them revealed EPEC in the fecal sample, while the 20 children control group showed no EPEC isolates in their samples. Our EPEC frequency showed variations from the compared results of other studies. Higher rate of EPEC (18.7%) was found in patients between 2 to 3 years, while EPEC rate was (7.5%) in patients less than 6 months old, with . EPEC was identified from fecal specimens as a unique pathogen or associated with other pathogens in acute and chronic diarrhea in children. EPEC were detected in all seasons except in winter, and was predominant in summer season. Four (57%) EPEC isolates were resistant to ampicillin, ticarcillin, and cotrimoxazole, and (14.3%) to the third generation cephalosporins.


2020 ◽  
Vol 47 (1) ◽  
pp. 12-19
Author(s):  
P. Murali ◽  
J. Radhika ◽  
D. Alwin

Objective: The appropriate function of the hypothalamic-pituitary-gonadal axis is essential for maintaining proper reproductive function. In female mammals, the hypothalamic-pituitary-gonadal axis regulates reproductive changes that take place in the estrus cycle and are necessary for successful reproduction. This study was conducted to investigate the effect of thymectomy on the estrus cycle in neonatally thymectomized guinea pigs.Methods: In this study, 12 female guinea pigs, six thymectomized and six sham-operated, were studied. The effects of neonatal thymectomy at 5–7 days of age on parameters of the reproductive axis were examined in female guinea pigs. Gonadotropin and 17β-estradiol levels were assessed at regular intervals (days 0, 3, 6, 9, 12, and 15) of the estrus cycle, and the time of vaginal opening in the thymectomized and shamoperated guinea pigs was determined.Results: Significant reductions in gonadotropins and 17β-estradiol levels during estrus cycle were found in neonatally thymectomized female guinea pigs compared to sham-operated guinea pigs.Conclusion: The results of this study underscore the importance of the thymus in the neonatal period for normal female reproductive function.


Author(s):  
Jiyoung Shin ◽  
Jiyoung Lee ◽  
Jueun Lee ◽  
Eun-Hee Ha

Environmental factors may play roles in the development of rheumatoid arthritis (RA), and some studies have shown that air pollution was associated with the development of autoimmune disease. This study was designed to investigate the effect of air pollutants on the development of adult RA. A nested case-control cohort study was performed using the National Health Insurance Service-National Sample Cohort during 2002–2014 in Korea. Air pollution data were collected from the National Ambient Air Monitoring System (NAMIS), and exposure levels were extrapolated using geographic information systems. The group with RA (n = 444) was compared with a propensity score-matched control group (n = 1776), and one-year average concentrations of air pollution were predicted at each patient’s residence. The adjusted binary logistic regression analysis showed a positive association between O3 exposure and the incidence risk of RA for the third (odds ratios (OR) = 1.45, 95% confidence intervals (CI): 1.08–1.96) and fourth (OR = 1.35, 95% CI: 1.00–1.83) quartiles in adults over 20 years of age. The third quartile CO exposure was also associated with an increased risk of RA (OR = 1.57, 95% CI: 1.16–2.12). The results of this nationwide population-based study showed that a one-year exposure to CO and O3 in adults was associated with an increased risk of RA.


2017 ◽  
Vol 6 (1) ◽  
pp. 93
Author(s):  
Warda Sada-Gerges (PhD )

In an ongoing search for new models to streamline college training and mentoring, a different training model was developed called the "Big Sister Model". This model was experienced for five years in the kindergarten-training program at the Kay College of education in Israel. Within this model, two female students are trained in each kindergarten: one in the third college year and the other in the second. Together with kindergarten staff, the two students plan the class curriculum and activities. A third-year student, who possess additional one year experience in practicing (veteran), has the opportunity to mentor a 2nd year student who also has the opportunity to observe the training of the third year and get more experience. This process provides a good staff relationship and develops interpersonal relations based on social and psychological elements, which points to a huge positive change in behavior, interpersonal relations and its motivations. In peer mentoring, the mentor accompanies, analyzes, supports, instructs, empowers and provides necessary knowledge in the mentoring process. It undergoes a process of empowerment, leadership, and success (Power et Al, 2011). This study is a continuous action research that aims at examining the effectiveness of the “Big sister” training model. When a third-year student mentors a second-year student, her personality will be accordingly empowered. Moreover, she is exposed to another year of the second year training program, once when she receives guidance in the second year and once more as a 3rd year student mentor. The second-year student enjoys continuous training throughout the day with a close colleague in addition to the training teacher and pedagogical mentor. In addition, she reveals the contents and skills of the third year allowing her ongoing internalization over time all third-year program. In the effectiveness of the training, we also sought to deeply examine the areas that this model promotes and strengthens as well as, how much the students perceive it as a training benefactor compared to the regular model in a control group.


2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Tong Xu ◽  
Xi Li ◽  
Lin Yang ◽  
Yongqiang Zhang ◽  
Li Zhang ◽  
...  

Female reproductive system diseases caused by exposure to a cold environment are widely considered as important human health challenges. Although the projection of female reproduction in cold temperature has been studied, a holistic view on the probable effects of cold exposure on the functions of the female reproductive system has not been achieved. Our aim was to evaluate the effects of cold exposure to the functions of the ovary and uterus in female rats. For this purpose, female rats were randomly grouped as follows: (1) the cold group was exposed to -10°C, 4 h per day for 2 weeks, and (2) the normal temperature (23 ± 1°C) group was used as control. Alterations were observed in different parameters, including body weight gain, organ coefficients, estrus cycle, and pathology of the cold-exposed female rats. Similarly, the serum reproductive hormones and mRNA expression were evaluated. Cold exposure induced estrus cycle irregularity and some alterations in the morphology of the ovary. Cold exposure impairs the function of the ovary probably by changing the level of serum LH and increasing LHR expression. Cold exposure induced a significant reduction of uterine epithelium height. Cold exposure causes alterations in the morphology of the uterus probably because of the effect of progesterone, the increase in the PR level, and the decrease in the ER level.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1155-1161
Author(s):  
Murali Punniakotti ◽  
Sundarapandian Subramanian ◽  
Pratheepa sivasankari

The proper function of the hypothalamic-pituitary-ovarian axis is essential for maintaining proper female reproductive function. In female mammals, the hypothalamic-pituitary-ovarian axis regulates reproductive changes that take place in the estrus cycle and are necessary for successful reproduction. This study aimed to investigate the influence of thymus gland on the female reproductive function in different stages of life. This present study was conducted to investigate the effect of thymectomy on the estrus cycle in prepubertal (5th week) and pubertal (7th week) thymectomized guinea pigs. In this study, 24 female guinea pigs, six thymectomized and six sham-operated in each group were studied. Gonadotropin and 17β-estradiol levels were assessed at regular intervals (days 0, 3, 6, 9, 12 and 15) of the estrus cycle, and the length of the oestrous cycle in the thymectomized and sham-operated guinea pigs was determined. The results showed no significant difference in gonadotropin and 17β-estradiol were detected in thymectomized versus sham-operated guinea pigs at any intervals of the oestrous cycle. Thymectomy did not affect the length of the oestrous cycle of females. In conclusion, the present study results suggested that the presence of thymus during prepubertal and pubertal life was not necessary to regulate the oestrous cycle of female guinea pigs.


2021 ◽  
Author(s):  
Shuai Wu ◽  
li zhang ◽  
Guanyu Zhang ◽  
Wanting Wei ◽  
Yongqiang Zhang ◽  
...  

Abstract Previous studies have shown that cold exposure can cause disturbance of estrus cycle in female rats. However, whether cold exposure can cause organic pathological damage to the reproductive system of female rats was undefined. Meanwhile there are few reports on the mechanism of decompensation in rat reproductive function after cold exposure. This study aims to further discuss how cold exposure impact female ovarian reserve function in rats. Female rats were randomly divided into control group and cold exposure group. Ovarian reserve function, differential genes in hypothalamus reproductive regulation center or peripheral were evaluated. After cold exposure, ovarian reserve function was impaired, follicle development was abnormal, the number of mature follicles decreased significantly, the key hypothalamic reproductive regulation molecule GnRH decreased significantly, the response of its regulatory receptor NPY-5R was down-regulated, and the peripheral hormone serum leptin, which is closely related to it, decreased significantly. Our results indicate that cold exposure can lead to impaired ovarian function in female rats, resulting from decrease in serum leptin cause by WAT leptin depletion, which can release the inhibitory of NPY in the hypothalamus, and further lead to the down-regulation of GnRH expression, resulting in the whole HPO axis.


2021 ◽  
Vol 22 (5) ◽  
pp. 745-753
Author(s):  
N. A. Shemuranova ◽  
N. A. Garifullina

The experiment was conducted on the basis of the agricultural production cooperative kolkhoz "Iskra" (Kirov region) in 40 highly productive cows of black-motley Holstein zed breed, which were divided by the method of paired analogues into 4 groups of 10 heads. The influence of the biologically active additive Lamarin Saldonum on the reproductive function and the milk productivity of cows was studied. The animals of the experimental groups were given the additive daily in doses of 0.1, 0.2 and 0.3 g per 1 kg of live weight for 30 days before calving during 60 days. It has been established that Lamarin Saldonum does not negatively affect the duration of pregnancy, while it helps to reduce the number of generic and postpartum diseases. In cows of the experimental groups retention of placenta was registered 10-20 % less often and the development of postpartum endometritis was observed 10-30 % less often. It was also found that in the animals of the experimental groups the indifferent period was reduced by 8.13-14.49 %, the number of days from calving to fruitful insemination was decreased by 30.51-53.82 days, the number of days of infertility was reduced by 33.63-59.37 % compared to intact animals. The cows of the second experimental group showed the best milk productivity, where the gross milk yield exceeded the values of the control group in the first month of lactation by 19.63 %, in the second - by 13.43 %, in the third - by 39.87 %. The need for additional studies to determine the effective dose of the additive Lamarin Saldonum, which will have a stimulating effect on the reproductive function of high-productive cows, has been established.


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