scholarly journals Influence of Marmix premix on the state of lipid peroxidation and indices of non-specific resistance of the organism of pregnant mares with microelementosis

2019 ◽  
Vol 10 (1) ◽  
pp. 87-91
Author(s):  
A. R. Shcherbatyy ◽  
L. G. Slivinska ◽  
B. V. Gutyj ◽  
V. L. Fedorovych ◽  
B. O. Lukashchuk
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Immune Complexes ◽  
Positive Influence ◽  
Lysozyme Activity ◽  
The State ◽  
Circulating Immune Complexes ◽  
Lipid Hydroperoxides ◽  
Diene Conjugates ◽  
Lipid Peroxidation Products

We observed the processes of lipid peroxidation, characterized by increased content of intermediate and its end products (diene conjugates, lipid hydroperoxides, malonic dialdehyde), in the blood of the pregnant mares. The changes of the data of indicators in the organism of the mares at the 9–11 months of pregnancy were established. The level of diene conjugates in the blood of animals was 3.6 ± 0.12 μmol/l, 33.3 and 44.0%, which was higher compared to non-pregnant mares and mares at 4th month of pregnancy. The concentration of lipid hydroperoxides in the blood of mares increased by 100% and by 42.9% in the blood of non-pregnant mares and mares at 4th month of pregnancy. The concentration of malondialdehyde in the blood of mares increased by 75.0%, 51.2% and 25.0% compared to non-pregnant mares and mares at 4th and 7th month of pregnancy, respectively. The results of our research showed that the mineral-vitamin premix Marmix had a positive influence on the state of lipid peroxidation products, contributed to their lowering in the blood of pregnant mares, which demonstrated antioxidant action and stimulated the function of the immune system. It was established that the bactericidal and lysozyme activity of the blood serum and the concentration of circulating immune complexes increases in the mares with lack of trace elements. It was shown that feeding mares during the 9–11 months of pregnancy with the mineral-vitamin premix Marmix had a positive influence on the state of humoral factors of nonspecific resistance. In particular, the concentration of bactericidal activity of serum increased by 31.0%, lysozyme activity of blood serum – 45.4% and contributed to the decrease of the concentration of circulating immune complexes in serum by 3.8 times. The use of mineral-vitamin premix Marmix during 60 days in feeding pregnant mares caused a restoration of the clinical status, a decrease in the content of lipid peroxidation products.

scholarly journals Content of lipid peroxidation products in pig meat at industrial and domestic slaughter

2020 ◽  
Vol 22 (99) ◽  
pp. 69-74
Author(s):  
I. Yu. Stronskyi ◽  
M. R. Simonov ◽  
Yu. S. Stronskyi
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Properties ◽  
Lipid Hydroperoxides ◽  
Secondary Products ◽  
Diene Conjugates ◽  
Lipid Peroxidation Products ◽  
Organoleptic Characteristics ◽  
Pig Meat ◽  
Meat Samples ◽  
Pig Carcasses

The nutritional value of meat, its organoleptic characteristics and therefore the shelf life depend on the content of lipid peroxidation products in it. Intermediates of peroxidation can have a toxic effect on the human body and are one of the main factors of non-microbial degradation of meat and various products. Based on this, the aim of this work was to study the content of lipid peroxidation products in pig meat of different origins. Furthermore, the aim was to establish the level of primary and secondary products of lipid peroxidation in meat, selected from different parts of the carcass. Meat samples were taken immediately after the pigs were slaughtered. A total of 3 meat samples were taken from 10 pig carcasses. One sample of meat was taken from each of the carcasses from the cervical, dorsal and femoral parts. The first 5 pigs were kept in industrial conditions and were slaughtered within the industrial slaughterhouse, and the second 5 were kept and slaughtered in personal farms. The results of the research showed that the highest level of primary and secondary products of lipid peroxidation is registered in the meat obtained from the dorsal part of pork carcass, which is primarily due to its fat-acid composition. In meat selected from the cervical and femoral parts, the level of the studied indicators is probably lower. During storage, lipid peroxidation activity increases from the first to the fourth day and decreases slightly until the seventh. The increase in the level of all studied indicators on the fourth day of meat storage is due to the fact that natural components contained in muscle tissue, such as ferrum, myoglobin, hydrogen peroxide and ascorbic acid can cause lipid oxidation, acting as catalysts or promoting the formation of reactive oxygen species. In the case of domestic keeping and slaughter, pig meat was found to have significantly higher concentrations of diene conjugates, lipid hydroperoxides and TBA-active products compared to industrial. The main prerequisite for this is an unbalanced diet, especially in terms of the content of substances that have antioxidant properties.

scholarly journals Nonspecific reactivity of the rabbits organism when exposed to cysticercosis

2019 ◽  
Vol 21 (94) ◽  
pp. 132-135
Author(s):  
Y. V. Duda
Keyword(s):  
Blood Serum ◽  
Bactericidal Activity ◽  
Immune Complexes ◽  
Research Group ◽  
Phagocytic Activity ◽  
Lysozyme Activity ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
E Coli ◽  
Test Culture

One of the actual rabbits breeding problem is the reduction of their resistance, which is caused by the spread of individual invasive diseases, especially cysticercosis, which is caused by the larval Cysticercus pisiformis stage of the mature cestode Taenia pisiformis. The study was conducted on 38 male rabbits age 3–4 months, weighing 3.5–4.0 kg of the Californian breed, selected by analogy. Animal were separated into two groups: healthy animals (control group) and sick animals (research group). After blood collection, slaughter was conducted and the presence of cysticercus cysts was visually determined in the organisms of the rabbits. Control animals received a balanced standard granular feed and water without limit; research group in addition to the standard granulated feed with water received flaccid hay. The animals were kept in mesh single-tier cages in the room, according to the current veterinary and sanitary standards. The definition of phagocytic activity of neutrophils was carried out with the addition of standardized to 2500000000/ml suspension of daily culture of E. coli 055K59№3912/41. The bactericidal activity of blood serum was determined by the method Smirnova A.V. and Kuzmina T.A. in relation to the E. coli microbial test-culture 055K59№3912/41. The serum lysozyme activity was determined by the Nephelometric method using the Dorofachuk V.G. method to the microbial test culture Micrococcus luteus ATSS9341. Circulating immune complexes were determined using polyethylene glycol in borate buffer (pH 8.4). It was found that in blood of sick animals phagocytic activity is lower than in blood of healthy ones (respectively, 41.82 ± 1.51% versus 47.38 ± 1.10%, P < 0.01). The main cells involved in phagocytosis are leukocytes, in particular neutrophils and eosinophils. A low indicator of phagocytic activity shows depressed phagocytosis in the organism of animals suffering from cysticercosis of rabbits. The phagocytic number in the blood of rabbits of the experimental group was significantly lower by 0.51 units (P < 0.05) as compared to the control group and correlated with the index of phagocytic activity. An important element of immunity are indicators of bactericidal and lysozyme activity of blood serum. Low bactericidal activity of serum by 12.88% (P < 0.01) and lysozyme activity in rabbits with Cysticercus pisiformis also indicates a weakening of the factors of nonspecific natural resistance of the organism. Analyzing the level of circulating immune complexes, we found a high level of medium (9.14 ± 0.40 vs 5.58 ± 0.50) and small (9.21 ± 1.35 vs 4.64 ± 0.68) CIC for cysticercosis, respectively, 1.64 (P < 0.01) and 1.98 times (P < 0.001) against the control. This indicates the inhibition of the immunobiological activity in the organism of rabbits as a result of the combination of specific antibodies with the products of the exchange of helminths.

scholarly journals Adaptation of the status of non-specific resistance of the ducks organism in stress conditions inclusion in the ration of probiotical additives

2018 ◽  
Vol 20 (87) ◽  
pp. 32-37 ◽  
Author(s):  
V.G. Stoyanovskyy ◽  
A.О. Krogh ◽  
I.A. Kolomiіets
Keyword(s):  
Body Weight ◽  
Blood Serum ◽  
Bactericidal Activity ◽  
Immune Complexes ◽  
Specific Resistance ◽  
Lysozyme Activity ◽  
The Body ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
Technological Stress

The article deals with the question of adaptation of the ducks organism during industrial cultivation for action of stress. The complex of successive stage reactions, caused by the functioning of stress-implementing systems, arise in the body of the poultry in response to the influence of destabilizing factors and aimed at neutralizing these factors, preservation of homeostasis. Increasing the influence of technological stress factors leads to a decrease in the immune status of the duck organism. The study of the effectiveness of incorporating into the diet ducks harmless feed additives, which contributes to the normalization of the course of adaptive-compensatory reactions in their body during the critical periods of postnatal ontogenesis and can serve as anti-stress prevention in conditions of industrial growth of this species of poultry remains relevant. The purpose of the work is to find out the implementation of an adaptation syndrome in the system of indices of non-specific resistance of the body of ducks when it is included in the diet of the biologically active feed supplement «Primix Bionorm K» and supplements «Biovir». The experiment was conducted on clinically healthy young ducks of the Pekin breed of egg production line. In the 270-day age, all three groups of ducks were modeled experimental technological stress in the form of prolonged transport. From 240 to 270 days of age, ducks additionally fed the additive «Primix Bionorm K» and was pouring with water an additive «Biovir». The material for research was blood, which was taken until morning feeding after slaughter on 240 days of life (to stress), 270 days of life (stage of anxiety), at 273 and 285 days (stages of resistance). Adaptation of the state of non-specific resistance of the duck of the control group to the control group under conditions of stress in the anxiety stage is characterized by an increase of 17.3% (Р < 0.05) of the value of the bactericidal activity of the blood serum, a decrease of 8.5% of the value of lysozyme activity of the blood serum, by 9.3% of phagocytic activity against the background of growth on 8.7% of the number of circulating immune complexes compared to 240-day-old poultry. At the stage of resistance there is a decrease in the amount of blood serum bactericidal activity by 17.3% (Р < 0.05), an increase in the activity of lysozyme in blood serum by 8.5%, and the number of immune complexes by 20.7% (Р < 0.05), with the stabilization of the studied parameters at the later stages of the development of a stress reaction. In these periods, a decrease in the body weight of control group ducks was set at 5.7 – 6.8%. Feeding of the additive «Primix Bionorm K» during the period of the implementation of the stress syndrome has a positive effect on the indices of the cellular and humoral level of nonspecific resistance in the form of an increase in the amount of bactericidal activity of the serum on 38.2% (P < 0.05), an increase in the activity of phagocytosis by 15.1% (P < 0.05), phagocytic index – by 36.1% (P < 0.05) with a decrease in the number of circulating immune complexes by 15.5%. The presentation of the additive «Biovir» causes an increase in the level of bactericidal and lysozyme activity of the blood serum on 47.3% (P < 0.01) and 18.7% (P < 0.05). The use of additives can reduce the negative effect of transport stress in the duck body, increase nutrient uptake, as indicated by an increase in the body weight of experimental birds in the average by 7.1–10.5% (P < 0.05) during the development of the adaptive syndrome.

CHANGE IN THE QUANTITATIVE CONTENT OF DIENE CONJUGATES IN THE ORAL FLUID IN RATS UNDER THE EXPOSURE OF TETRAMETHYLTHIURAM DISULFIDE

2020 ◽  
Author(s):  
Лилия Александровна Ячменева ◽  
Владимир Анатольевич Королев ◽  
Елена Викторовна Фелькер ◽  
Иван Владимирович Королев
Keyword(s):  
Lipid Peroxidation ◽  
Toxic Effect ◽  
Oral Fluid ◽  
Diene Conjugates ◽  
Tetramethylthiuram Disulfide ◽  
Lipid Peroxidation Products ◽  
Quantitative Content

Целью исследования было установить уровень диеновых конъюгатов в ротовой жидкости при интоксикации тетраметилтиурамдисульфидом. В результате было установлено, что на 28 сутки был выявлен наибольший токсический эффект ТМДТ, который превысил контрольные значения в 4 раза (400%). Концентрация ДК на 7, 14, 21 сутки возросла на 158,3%, 225,0%, 258,3% соответственно. Полученные результаты говорят о накоплении продуктов перекисного окисления липидов диеновых конъюгатов с увеличением сроков пестицидной интоксикации. The aim of the study was to determine the level of diene conjugates in the oral fluid during tetramethylthiuram disulfide intoxication. As a result, it was found that on day 28, the greatest toxic effect of TMDT was detected, which exceeded the control values by 4 times (400%).. The concentration of DC on days 7, 14, and 21 increased by 158.3%, 225.0%, and 258.3%, respectively. The results obtained indicate the accumulation of lipid peroxidation products of diene conjugates with an increase in the duration of pesticide intoxication.

Multivitamin and mineral supplementation in 1,2-dimethylhydrazine induced experimental colon carcinogenesis and evaluation of free radical status, antioxidant potential, and incidence of ACF

2012 ◽  
Vol 90 (1) ◽  
pp. 45-54 ◽  
Author(s):  
Albert Baskar Arul ◽  
Ignacimuthu Savarimuthu ◽  
Mohammed A. Alsaif ◽  
Khalid S. Al Numair
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Reduced Glutathione ◽  
Colon Carcinogenesis ◽  
Aberrant Crypt Foci ◽  
Lipid Hydroperoxides ◽  
Entire Study ◽  
Lipid Peroxidation Products ◽  
Histopathological Alterations ◽  
Mineral Supplementation

This study was performed to determine the chemopreventive and antioxidant status of multivitamin and mineral (0.01% in drinking water, ad libitum) supplements in 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis. Experimental colon carcinogenesis was induced in male albino Wistar rats by injecting DMH (20 mg·(kg body mass)–1) once weekly for 15 consecutive weeks, and administering a multivitamin supplement in 3 regimes (initiation, post-initiation, and entire experimental period) for 32 weeks. We studied lipid peroxidation products (thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) in the circulation and in the tissues, antioxidant status (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and non-enzymatic antioxidant-reduced glutathione) of the tissues, aberrant crypt foci (ACF), and histopathological alterations. DMH-induced rats had an increase in lipid peroxidation products and a lower antioxidant status compared with control animals. Multivitamin and mineral supplementation during the initiation, post-initiation, and the entire study period significantly decreased the levels of lipid peroxidation products in circulation and colonic tissues, significantly elevated the activities of the antioxidant enzymes and reduced glutathione to near normalcy in DMH-induced rats. The incidence of ACF was reduced to 84.1% in rats supplemented with multivitamin and minerals for the entire study and prevented the colonic tissue from histopathological alterations induced by DMH.

scholarly journals The cell protection of weated pigs for probiotics

2020 ◽  
pp. 111-119
Author(s):  
L. Bondarenko
Keyword(s):  
Immune System ◽  
Blood Serum ◽  
Phagocytic Activity ◽  
Lysozyme Activity ◽  
The State ◽  
Natural Resistance ◽  
Phagocytic Index ◽  
Control Group ◽  
Stressful Situation ◽  
Experimental Group

The immune system is central to ensuring the consistency of the body's homeostasis. The state of the body's natural resistance is determined by a set of non-specific protective mechanisms. Lymphocytes and phagocytes are actively involved in maintaining immunity. Lymphocytes recognize the antigens of pathogenic microorganisms, and phagocytes absorb and destroy the pathogens themselves. During the weaning of piglets from sows there is a decrease in the protective forces of their body. During this period, the natural resistance of the piglets is reduced due to the stressful situation caused by changing conditions of confinement, the transition to full feed and lack of sows. The immune system of weaning pigs is relatively weak, so when exposed to environmental and technological stressors, they become susceptible to various diseases. The use of probiotic drugs stimulates the activity of the immune system, prevents stress and immunodeficiency. One of these probiotics is the probiotic of domestic production Protecto-active. It w observed the the influence of the probiotic Protecto-active on the indices of nonspecific resistance of the young pigs organism to the growth. An increase in bactericidal activity of blood serum by 12.10% (P <0.05) and lysozyme activity of blood in the piglets of the experimental group was increased by 3.71% compared to control, which indicates the activation of the body's defenses and the increase in adaptive capacity. An important step in the study of the influence of the probiotic Protekto-active on the state of the immune system is to determine the phagocytic activity of neutrophils, phagocytic index and phagocytic number. In the experimental group of piglets that were fed the probiotic Protecto-active, we found an increase in leukocyte phagocytic activity by 9.0% (P <0.001), a phagocytic index by 51.7% (P<0.001) and a phagocytic number by 24.8% ( P <0.01) compared with the control group. Thus, using a probiotic Protecto-active, all indicators of phagocytosis increase: the number of phagocytes increases, their ability to capture microorganisms and increases their digestive capacity, it increases the bacterial and lysozyme activity of blood serum, which is positively reflected in the immunobiosity. Key words: probiotic, phagocytosis, phagocytic index, phagocytic number, phagocytic activity of leukocytes, cellular immunity, piglets

scholarly journals Features of free radical lipid peroxidation and serum proteins at dental implants and peri-implantitis

2015 ◽  
Vol 96 (5) ◽  
pp. 756-759 ◽  
Author(s):  
D V Plyukhin ◽  
V E Tseylikman ◽  
O B Tseylikman ◽  
A I Sinitskiy
Keyword(s):  
Lipid Peroxidation ◽  
Free Radical ◽  
Blood Serum ◽  
Dental Implants ◽  
Schiff Bases ◽  
Free Radical Oxidation ◽  
Protein Carbonylation ◽  
Radical Oxidation ◽  
Lipid Peroxidation Products ◽  
Dental Implantation

Aim. Determine the most informative indicators of free radical peroxidation in blood plasma for predicting the complications of dental implantation. Methods. The study included 84 patients of both with dental implants, including 31 patients without any complications and 53 patients with peri-implantitis. The levels of lipid peroxidation products and protein carbonylation were measured in peripheral blood. Results. Moderate intensification of lipid peroxidation and protein carbonylation was discovered in blood serum of patients with dental implants. Increased free radical oxidation in the blood was not limited to lipid peroxidation and resulted in increased serum levels of carbonylated proteins. Facilitation of oxidative degradation of proteins in the blood was associated with decreased resistance to «carbonyl stress», manifested as increased level of Fe+2/H2O2-induced carbonylation. Development of peri-implantitis resulted in a greater enhancement of free radical oxidation of blood. Isopropanol-soluble and heptane-soluble Schiff bases level was increased in blood serum as well. Similar to patients with dental implants, increased levels of carbonylated proteins was observed in blood serum at peri-implantitis. However, free radical oxidation was more intense in patients with peri-implantitis compared to patients with dental implants. Indeed, the level of heptane-soluble Schiff bases at the group with peri-implantitis was 2 times higher as compared to dental implants group, and the level of isopropanol-soluble lipid peroxidation products in inflammatory complications after implantation has reached fourfold increase compared with patients who underwent operation without complications. Conclusion. Investigated indicators of free radical oxidation may be used as markers of peri-implantitis. Among them, the most informative indicators are Schiff bases and metal-catalyzed protein oxidation.

scholarly journals The effect of interferons-α and –γ and their combination with dimethyl dipyrazolyl selenide on the immune status and functional state of the reproductive system of cows in adverse ecological conditions

2019 ◽  
pp. 53-57
Author(s):  
A. G. Shakhov ◽  
I. T. Shaposhnikov ◽  
Yu. N. Brigadirov ◽  
V. N. Kotsarev ◽  
V. N. Skorikov ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Functional State ◽  
Reproductive System ◽  
Immune Complexes ◽  
Immune Status ◽  
Lysozyme Activity ◽  
Circulating Immune Complexes ◽  
Control Group ◽  
Ecological Conditions ◽  
Positive Effect

The results of studying the effect of interferons alpha and gamma and their combination with dimethyl dipyrazolyl selenide on the immune status and functional state of the reproductive system of cows in adverse ecological conditions are presented. The positive effect of the drugs, especially their combination, on erythropoiesis and the immune status of animals, which was manifested by an increase in the content of erythrocytes, hemoglobin, hematocrit, leukocytes, total immunoglobulins, serum bactericidal and lysozyme activity, absorptive function of phagocytes, relative amount of T lymphocytes, and a decrease in the level of circulating immune complexes was stated. An increase in the immune status of animals at the effect of immunocorrecting drugs was accompanied by a decrease in the pathology of calving and postpartum complications and favorably affected the functional state of their reproductive system. The cows which were introduced interferons and their combination with dimethyl dipyrazolyl selenide demonstrated a shorter period from calving to successful insemination, as well as the insemination index and fertility, compared with the animals of the control group, which were not introduced any drugs.

scholarly journals The ratio of erythrocyte populations in the blood of puppies during postnatal oxidative stress

2019 ◽  
pp. 81-87
Author(s):  
M. Anfiorova ◽  
M. Broshkov ◽  
O. Danchuk
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Key Words ◽  
Schiff Bases ◽  
The Body ◽  
Peroxide Oxidation ◽  
Diene Conjugates ◽  
Lipid Peroxidation Products ◽  
End Products ◽  
Conjugated Trienes

The article presents new scientifi c data on the ratio of erythrocyte populations in puppies' blood during postnatal oxidative stress. It was established that the number of erythrocytes in the blood of one-day-old puppies was 5.64 ± 0.12 T / l, and half of these cells belonged to the population of "mature", 40% - "young" and 10% - "old". In day-old puppies, the content of lipid peroxidation products in erythrocyte hemolysates is quite high, which indicates the development of postnatal oxidative stress. Thus, the content of diene conjugates, ketodienes and Schiff bases is respectively 1,406 ± 0,023 Conv. units, 0.676 ± 0.004 Conv. units and 0.135 ± 0.003 Conv. units. From one to fi ve days age of puppies the number of erythrocytes in the blooddecrease by 1.5 times (p<0.001), mainly due to the decrease in the number of "mature" cells (by 1.6 times; p<0.001). The intensity of peroxide oxidation in the body of puppies even a month after birth is relatively high, as indicated by the content of Schiff bases in the erythrocytes of the blood of these animals - 0.185 ± 0.002 Conv.units. The inverse correlations of the content of Schiff bases in erythrocyte hemolysate with their number in the bloodstream were found to be r = -0.83 (p<0.001). It should also be noted the direct correlation of the content of diene conjugates in the blood of puppies with the number of erythrocytes in their blood (r = 0,58 p <0,05), but the content of ketodienes and conjugated trienes is inversely related to the content of "young" erythroid cells in the puppies' blood (r = -0.57 p <0.05). Consequently, post-natal adaptation of puppies results in the replacement of fetal erythrocytes by postnatal cells, and this process is associated with the intensifi cation of peroxide oxidation and accumulation of the end products of peroxidationin the cells. This process isaccompanied by an acceleration of the process of "aging" of young forms of erythrocytes, as a result of which prerequisites for the development of anemiaare created. Key words: erythrocytes, oxidative stress, puppies, Schiff bases, ketodienes, diene conjugates.

DYNAMICS OF THE LEVEL OF CIR-CULATING IMMUNE COMPLEXES IN BLOOD SERUM IN RABBITS UNDER MODEL STRESSES

2020 ◽  
Vol 3 ◽  
pp. 135-138
Author(s):  
O. V. Kryachko ◽  
◽  
L.A. Lukoyanova ◽  
Keyword(s):  
Blood Serum ◽  
Immune Complexes ◽  
Live Weight ◽  
Circulating Immune Complexes ◽  
Stress Factors ◽  
Innate Immune Responses ◽  
Stress Effects ◽  
Transport Stress ◽  
Post Stress ◽  
Dorsal Position

A small amount of circulating immune complexes is determined in a healthy body, and it naturally increases when there is an antigen in the circulation. Stressful situations can inhibit the implementation of immune protection, both adaptive and innate immune responses. The purpose of this study was to study the dynamics of the level of circulating immune complexes in blood serum after modeling single and combined stress effects in rabbits. 10 male rabbits were used for the experiment. The animals were 8 months old and had a live weight of 3.40±0.73 kg. Transport stress was caused by transporting animals in a car. Immobilization stress was modeled by fixing rabbits in a fixation de-vice for small animals by their legs in the dorsal position. In the final series of experi-ments, a combination of actions was per-formed (immobilization, then, after three days, transportation). As a result of studies it was found that the reaction of animals to stress was characterized by decreased level of the CIC, during transportation (by 1.2 times (p<0.05) and immobilization (1.6 times, p<0.05), the combination of stress factors showed a similar effect. In the post-stress period, we observed in all cases an increase in the CIC level in the blood of rab-bits, which exceeded the CIC values both at the time of the stress reaction and the level of intact animals.

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