scholarly journals CD166 as a Stem Cell Marker? A Potential Target for Therapy Colorectal Cancer?

2016 ◽  
Vol 1 (6) ◽  
Author(s):  
Hassan Dana
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Potential Target

scholarly journals Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer

2012 ◽  
Vol 13 (4) ◽  
pp. 4367-4387 ◽  
Author(s):  
Manuel Valladares-Ayerbes ◽  
Moisés Blanco-Calvo ◽  
Margarita Reboredo ◽  
María J. Lorenzo-Patiño ◽  
Pilar Iglesias-Díaz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker

scholarly journals Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer

2019 ◽  
Vol 8 (4) ◽  
pp. CRC11 ◽  
Author(s):  
Chukwuemeka Ihemelandu ◽  
Aisha Naeem ◽  
Erika Parasido ◽  
Deborah Berry ◽  
Krysta Chaldekas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Marker ◽  
Prognostic Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Independent Prognostic Marker ◽  
Lgr5 Expression

Aim: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). Patients & methods: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009–2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray. Results: LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival. Conclusion: LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.

scholarly journals Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer

2014 ◽  
Vol 7 (5) ◽  
pp. 1544-1548 ◽  
Author(s):  
DAN LIU ◽  
JINGHUA SUN ◽  
JINMING ZHU ◽  
HUAN ZHOU ◽  
XIAN ZHANG ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Clinical Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients

Tumor Biology ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 4801-4810 ◽  
Author(s):  
Alireza Mirzaei ◽  
Gholamreza Tavoosidana ◽  
Mohammad Hossein Modarressi ◽  
Afshin Abdi Rad ◽  
Mohammad Sadegh Fazeli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Patients ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Colorectal Cancer Patients

Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods

2016 ◽  
Vol 17 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Alireza Mirzaei ◽  
Zahra Madjd ◽  
Azade Amini Kadijani ◽  
Masoumeh Tavakoli-Yaraki ◽  
Mohammad Hossein Modarresi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals The Stem Cell Marker CD133 Associates with Enhanced Colony Formation and Cell Motility in Colorectal Cancer

PLoS ONE ◽  
2010 ◽  
Vol 5 (5) ◽  
pp. e10714 ◽  
Author(s):  
Tarek M. A. Elsaba ◽  
Luisa Martinez-Pomares ◽  
Adrian R. Robins ◽  
Simon Crook ◽  
Rashmi Seth ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cell Motility ◽  
Colony Formation ◽  
Stem Cell Marker ◽  
Cell Marker

Participation of Laminin α5-Chain in the Regulation of Colorectal Cancer Cell Differentiation

2019 ◽  
Vol 35 (6) ◽  
pp. 3-11
Author(s):  
M.P. Raigorodskaya Raigorodskaya ◽  
I.M. Tsypina ◽  
A. Turchinovich ◽  
V.G. Zgoda ◽  
S.V. Nikulin
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Intestinal Epithelium ◽  
Transmembrane Protein ◽  
Wnt Signaling Pathway ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Russian Science ◽  
Endogenous Expression

The effect of endogenous expression of the laminin α5 chain on the phenotype of colorectal cancer cells has been studied. For this purpose, the knockdown of LAMA5 gene coding for the α5 laminin chain in the HT29 colorectal adenocarcinoma cell line was carried out. The data on gene expression at both mRNA and protein levels indicate that the α5 laminin chain is involved in the regulation of cell differentiation. For example, a decrease in the expression of such markers of differentiation of the intestinal epithelium as SI, KRT20, ANXA13 and MUC13 was observed. In addition, the expression of the intestinal epithelial stem cell marker LRG5 and CD44 transmembrane protein was increased. Changing the phenotype of HT29 cells may be a result of the effect of the laminin α5 chain on the activity of the Wnt signaling pathway. colorectal cancer, laminin, differentiation, dedifferentiation, intestinal epithelium stem cell marker, HT29, LAMA5, LRG5 The study was funded by the Russian Science Foundation (Project no. 17-14-01338).

Stem Cell Marker Expression in Early Stage Colorectal Cancer is Associated with Recurrent Intestinal Neoplasia

2020 ◽  
Vol 44 (10) ◽  
pp. 3501-3509
Author(s):  
Brett S. Walker ◽  
Luai R. Zarour ◽  
Nicole Wieghard ◽  
Alexandra C. Gallagher ◽  
John R. Swain ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Early Stage ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Intestinal Neoplasia ◽  
Marker Expression
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