Evaluation of circulating cellular DCLK1 protein, as the most promising colorectal cancer stem cell marker, using immunoassay based methods

2016 ◽  
Vol 17 (3) ◽  
pp. 301-311 ◽  
Author(s):  
Alireza Mirzaei ◽  
Zahra Madjd ◽  
Azade Amini Kadijani ◽  
Masoumeh Tavakoli-Yaraki ◽  
Mohammad Hossein Modarresi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

scholarly journals Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer

2019 ◽  
Vol 8 (4) ◽  
pp. CRC11 ◽  
Author(s):  
Chukwuemeka Ihemelandu ◽  
Aisha Naeem ◽  
Erika Parasido ◽  
Deborah Berry ◽  
Krysta Chaldekas ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Marker ◽  
Prognostic Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Independent Prognostic Marker ◽  
Lgr5 Expression

Aim: To analyze the clinicopathologic and prognostic significance of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a cancer stem cell marker expression in a cohort of colorectal cancer patients (CRC). Patients & methods: A total of 76 formalin-fixed paraffin-embedded tissue blocks of primary or metastatic tumors from 49 CRC patients were collected for duration 2009–2015. LGR5 expression was assessed through immunohistochemical staining of a tissue microarray. Results: LGR5 was significantly over expressed in CRC tissue samples and found to be a statistically significant independent prognostic marker for an improved overall survival. Conclusion: LGR5 expression was higher in colorectal cancer than in normal tissue. LGR5 was an independent prognostic marker for better clinical outcomes and might be used as a potential therapeutic target in CRCs.

scholarly journals Expression and clinical significance of colorectal cancer stem cell marker EpCAMhigh/CD44+ in colorectal cancer

2014 ◽  
Vol 7 (5) ◽  
pp. 1544-1548 ◽  
Author(s):  
DAN LIU ◽  
JINGHUA SUN ◽  
JINMING ZHU ◽  
HUAN ZHOU ◽  
XIAN ZHANG ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Clinical Significance ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker

Upregulation of circulating cancer stem cell marker, DCLK1 but not Lgr5, in chemoradiotherapy-treated colorectal cancer patients

Tumor Biology ◽  
2015 ◽  
Vol 36 (6) ◽  
pp. 4801-4810 ◽  
Author(s):  
Alireza Mirzaei ◽  
Gholamreza Tavoosidana ◽  
Mohammad Hossein Modarressi ◽  
Afshin Abdi Rad ◽  
Mohammad Sadegh Fazeli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Patients ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Colorectal Cancer Patients

scholarly journals Prognostic Value of Cancer Stem Cell Marker ALDH1 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145164 ◽  
Author(s):  
Jinhuang Chen ◽  
Qinghua Xia ◽  
Bin Jiang ◽  
Weilong Chang ◽  
Wenzheng Yuan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Aldh1 Expression
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