scholarly journals Color Coded Perfusion Imaging with Contrast Enhanced Ultrasound (CEUS) for Post-Interventional Success Control Following Irreversible Electroporation (IRE) of Primary and Secondary Malignant Liver Lesions

2019 ◽  
Vol 28 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Janine Rennert ◽  
Isabel Wiesinger ◽  
Andreas Schicho ◽  
Philipp Wiggermann ◽  
Christian Stroszczynski ◽  
...  
Keyword(s):  
Irreversible Electroporation ◽  
Area Under The Curve ◽  
Liver Lesions ◽  
Metastatic Lesions ◽  
Peak Enhancement ◽  
Contrast Enhanced ◽  
Malignant Lesions ◽  
Perfusion Quantification ◽  
Malignant Liver ◽  
Malignant Liver Lesions

Aim: Evaluation of the post-interventional success following irreversible electroporation (IRE) using a new color coded perfusion quantification software with contrast-enhanced ultrasound (CEUS) in patients with malignant lesions of the liver. Methods: Thirty-eight patients with 68 malignant liver lesions underwent IRE. All malignant lesions were investigated with CEUS before and within 24 hours following IRE to detect residual tumor tissue. The parameters analyzed by color coded perfusion quantification software were: the peak enhancement (pE), time to peak (TTP), mean transit time (mTT), rise (Ri) and wash-in area under the curve (WiAUC). Perfusion in the center, the margins of the lesions and in the surrounding liver were evaluated using these parameters. Results: Hepatocellular carcinoma (HCC) with complete ablation showed significantly different changes between the center and the margin of the lesions for WiAUC (p<0.05) and pE (p<0.01). Also significant differences were noted between the center of the lesions and the surrounded tissue for the same parameters (p<0.01). In the completely ablated metastatic lesions, significant differences were found between the center of the lesion and the margins (p < 0.01) and between the center of the lesion and the surrounding liver (p < 0.05) for WiAUC. mTT, TTP and Ri showed no significant changes between the center of the lesions, margin of the lesions or surrounding tissue. Also, no significant differences were found for these parameters in the different regions of interest for HCC or the metastatic lesions with partial ablation success. Conclusion: CEUS with perfusion imaging is a valuable supporting tool for the post-interventional evaluation of liver lesions following IRE. Focus should be placed on the peak enhancement (pE) and the wash-in area under the curve (WiAUC).

Contrast-enhanced ultrasound of malignant liver lesions

2017 ◽  
Vol 43 (4) ◽  
pp. 819-847 ◽  
Author(s):  
Isabelle Durot ◽  
Stephanie R. Wilson ◽  
Jürgen K. Willmann
Keyword(s):  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Malignant Liver ◽  
Malignant Liver Lesions

Local Control of Perivascular Malignant Liver Lesions Using Percutaneous Irreversible Electroporation: Initial Experiences

2014 ◽  
Vol 38 (1) ◽  
pp. 152-159 ◽  
Author(s):  
Achim Eller ◽  
Axel Schmid ◽  
Joachim Schmidt ◽  
Matthias May ◽  
Michael Brand ◽  
...  
Keyword(s):  
Local Control ◽  
Irreversible Electroporation ◽  
Liver Lesions ◽  
Malignant Liver ◽  
Malignant Liver Lesions

scholarly journals Triple-Phase Multidetector Computed Tomography in Distinguishing Canine Hepatic Lesions

Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 11
Author(s):  
Ladislav Stehlík ◽  
Morena Di Tommaso ◽  
Francesca Del Signore ◽  
Michaela Paninárová ◽  
Rossella Terragni ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Phase Contrast ◽  
Normal Liver ◽  
Liver Parenchyma ◽  
Liver Lesions ◽  
Contrast Enhanced ◽  
Malignant Liver ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography ◽  
Malignant Liver Lesions

The liver has a unique vascular supply, and triple-phase contrast-enhanced computed tomography examinations are being performed in order to characterize liver lesions. This study aimed to look for any associations between the attenuation values of liver lesions and their histological classification. The inclusion criteria for this retrospective study were focal or multifocal liver lesions and histological diagnosis. All of the dogs underwent pre-contrast and triple-phase postcontrast computed tomography (CT) examinations with identical timings of the postcontrast series. Thirty-one dogs were included in the study, and various benign and malignant pathologies were identified. The results did not identify any significant differences between the benign and malignant liver lesions, nor between the individual histological diagnoses. Inflammatory lesions were significantly different compared to the normal liver parenchyma, and significant hypoattenuation was found in the portal and delayed venous phases. Hemangiosarcomas were significantly hypoattenuating to the normal liver parenchyma in the pre-contrast and arterial phases, and also to all of the benign lesions in the arterial phase. The other pathologies showed variable attenuation patterns in the different postcontrast phases, and differentiation was not possible. On the basis of this study, triple-phase contrast-enhanced computed tomography cannot differentiate between benign and malignant liver lesions, and biopsy and further histological analysis are necessary.

A case of misdiagnosis of liver cancer with metastases in a patient with systemic vasculitis

1999 ◽  
Vol 80 (1) ◽  
pp. 72-72
Author(s):  
N. Y. Savushkina ◽  
T. A. Fatykhova
Keyword(s):  
Liver Cancer ◽  
Systemic Vasculitis ◽  
Metastatic Lesion ◽  
Focal Lesion ◽  
Frequency Of Occurrence ◽  
Liver Lesions ◽  
Metastatic Lesions ◽  
Malignant Liver ◽  
Malignant Liver Lesions

In the group of malignant liver lesions, the frequency of occurrence of metastatic lesions is in the first place. It is distinguished by a pronounced variety of the echographic picture. However, not always a vivid picture of focal lesion corresponds to a true metastatic lesion. The presented observation can serve as an example of such a situation.

Characterizing malignant liver lesions with contrast-enhanced ultrasound

2014 ◽  
Vol 75 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Mark Wills ◽  
Chris J Harvey ◽  
Siarhei Kuzmich ◽  
Asim Afaq ◽  
Adrian Lim ◽  
...  
Keyword(s):  
Liver Lesions ◽  
Contrast Enhanced Ultrasound ◽  
Contrast Enhanced ◽  
Malignant Liver ◽  
Malignant Liver Lesions

Diagnostic accuracy of apparent diffusion coefficient (ADC) value in differentiating malignant from benign solid liver lesions: a systematic review and meta-analysis

2021 ◽  
pp. 20210059
Author(s):  
Farhad Nalaini ◽  
Fatemeh Shahbazi ◽  
Seyedeh Maryam Mousavinezhad ◽  
Ali Ansari ◽  
Mohammadgharib Salehi
Keyword(s):  
Systematic Review ◽  
Diffusion Coefficient ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Liver Lesions ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Malignant Lesions ◽  
Malignant Liver ◽  
Malignant Liver Lesions

Objectives: We undertook a systematic review and meta-analysis of the diagnostic performance of mean apparent diffusion coefficient (ADC) values derived by diffusion-weighted (DW)-MRI in the characterization of solid benign and malignant liver lesions, and to assess their value in discriminating these lesions in daily routine practice. Methods: A systematic review of PubMed, Embase, Scopus, and Web of Science was conducted to retrieve studies that used ADC values for differentiating solid benign/dysplastic nodules and malignant liver lesions. A bivariate random-effects model with pooled sensitivity and specificity values with 95% CI (confidence interval) was used. This meta-analysis was performed on the per-lesion basis. Summary receiver operating characteristic (SROC) plot and area under curve (AUC) were created. Results: A total of 14 original articles were retrieved. The combined (95% CI) sensitivity and specificity of mean ADC values for differentiating solid benign from malignant lesions were 78% (67 to 86%) and 74% (64 to 81%), respectively. The pooled (95% CI) positive and negative LRs were respectively 3 (2.3 to 3.8) and 0.3 (0.21 to 0.43). The DOR (95% CI) was 10 (7 to 15). The AUC (95% CI) of the SROC plot was 82% (78 to 85%). Reporting bias was negligible (P value of regression test = 0.36). Mean size of malignant lesions and breathing pattern of MRI were found to be sources of heterogeneity of pooled sensitivity. Conclusion: ADC measurement independently may not be an optimal diagnostic imaging method for differentiating solid malignant from solid benign hepatic lesions. The meta-analysis showed that ADC measurement had moderate diagnostic accuracy for characterizing solid liver lesions. Further prospective and comparative studies with pre-specified ADC thresholds could be performed to investigate the best MRI protocol and ADC threshold for characterizing solid liver lesions. Advances in knowledge: ADC measurement by DW-MRI does not have a good diagnostic performance to differentiate solid malignant from solid benign lesions. Therefore, we suggest not using ADC values in clinical practice to evaluate solid liver lesions.

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