scholarly journals A Large-scale Analysis of Human Mitochondrial DNA Sequences with Special Reference to the Population History of East Eurasian.

2002 ◽  
Vol 110 (3) ◽  
pp. 293-312 ◽  
Author(s):  
H. Oota ◽  
N. Saitou ◽  
S. Ueda
Keyword(s):  
Mitochondrial Dna ◽  
Special Reference ◽  
Dna Sequences ◽  
Large Scale ◽  
Population History ◽  
Scale Analysis ◽  
Human Mitochondrial Dna ◽  
Large Scale Analysis ◽  
History Of

scholarly journals Estimating Ancestral Population Parameters

Genetics ◽  
1997 ◽  
Vol 145 (3) ◽  
pp. 847-855 ◽  
Author(s):  
John Wakeley ◽  
Jody Hey
Keyword(s):  
Mitochondrial Dna ◽  
Computer Simulations ◽  
Dna Sequences ◽  
Population History ◽  
Ancestral Population ◽  
Change Model ◽  
Population Parameters ◽  
Size Change ◽  
Single Population ◽  
Human Mitochondrial Dna

The expected numbers of different categories of polymorphic sites are derived for two related models of population history: the isolation model, in which an ancestral population splits into two descendents, and the size-change model, in which a single population undergoes an instantaneous change in size. For the isolation model, the observed numbers of shared, fixed, and exclusive polymorphic sites are used to estimate the relative sizes of the three populations, ancestral plus two descendent, as well as the time of the split. For the size-change model, the numbers of sites segregating at particular frequencies in the sample are used to estimate the relative sizes of the ancestral and descendent populations plus the time the change took place. Parameters are estimated by choosing values that most closely equate expectations with observations. Computer simulations show that current and historical population parameters can be estimated accurately. The methods are applied to DNA data from two species of Drosophila and to some human mitochondrial DNA sequences.

scholarly journals Advances in decomposing complex metabolite mixtures using substructure- and network-based computational metabolomics approaches

2021 ◽  
Author(s):  
Mehdi A. Beniddir ◽  
Kyo Bin Kang ◽  
Grégory Genta-Jouve ◽  
Florian Huber ◽  
Simon Rogers ◽  
...  
Keyword(s):  
Natural Product ◽  
Large Scale ◽  
Scale Analysis ◽  
Computational Tools ◽  
Natural Product Discovery ◽  
Large Scale Analysis ◽  
Metabolite Annotation

This review highlights the key computational tools and emerging strategies for metabolite annotation, and discusses how these advances will enable integrated large-scale analysis to accelerate natural product discovery.

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