scholarly journals Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females

Genetics ◽  
2018 ◽  
Vol 209 (4) ◽  
pp. 1155-1166 ◽  
Author(s):  
Lesley N. Weaver ◽  
Daniela Drummond-Barbosa
Keyword(s):  
Stem Cell ◽  
Cell Number ◽  
Germline Stem Cell ◽  
Adult Drosophila

scholarly journals LIN-28 balances longevity and germline stem cell number inCaenorhabditis elegansthrough let-7/AKT/DAF-16 axis

Aging Cell ◽  
2016 ◽  
Vol 16 (1) ◽  
pp. 113-124 ◽  
Author(s):  
Dan Wang ◽  
Lei Hou ◽  
Shuhei Nakamura ◽  
Ming Su ◽  
Fang Li ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Number ◽  
Germline Stem Cell

scholarly journals Niche maintenance of germline stem cells in C. elegans males

2018 ◽  
Author(s):  
Sarah L. Crittenden ◽  
ChangHwan Lee ◽  
Ipsita Mohanty ◽  
Sindhu Battula ◽  
Judith Kimble
Keyword(s):  
Stem Cell ◽  
Cell Number ◽  
Germline Stem Cell ◽  
Sexually Dimorphic ◽  
Common Theme ◽  
Germline Stem Cells ◽  
Cellular Behavior ◽  
C Elegans ◽  
Stem Cell Maintenance ◽  
Cell Maintenance

ABSTRACTStem cell maintenance by niche signaling is a common theme across phylogeny. In the Caenorhabditis elegans gonad, the broad outlines of germline stem cell (GSC) regulation are the same for both sexes: GLP-1/Notch signaling from the mesenchymal Distal Tip Cell (DTC) niche maintains GSCs in the distal gonad of both sexes (Austin and Kimble 1987), and does so via two key stem cell regulators, SYGL-1 and LST-1 (Kershneret al. 2014). Most analyses of niche signaling and GSC regulation have focused on XX hermaphrodites, an essentially female sex making sperm in larvae and oocytes in adults. Here we focus on XO males, which are sexually dimorphic in all tissues, including the distal gonad. The architecture of the male niche and the cellular behavior of GSCs are sex-specific. Despite these differences, males maintain a GSC pool similar to the hermaphrodite with respect to size and cell number and the male GSC response to niche signaling is also remarkably similar.

scholarly journals A model for adult organ resizing demonstrates stem cell scaling through a tunable commitment rate

2017 ◽  
Author(s):  
XinXin Du ◽  
Lucy Erin O’Brien ◽  
Ingmar Riedel-Kruse
Keyword(s):  
Stem Cell ◽  
Theoretical Models ◽  
Cell Number ◽  
Cellular Behaviors ◽  
Tissue Space ◽  
Physiological Demands ◽  
Kinetics Of ◽  
Cell Proportion ◽  
Adult Drosophila

AbstractMany adult organs grow or shrink to accommodate different physiological demands. Often, as total cell number changes, stem cell number changes proportionally in a phenomenon called ‘stem cell scaling’. The cellular behaviors that give rise to scaling are unknown. Here we study two complementary theoretical models of the adult Drosophila midgut, a stem cell-based organ with known resizing dynamics. First, we derive a differential equations model of midgut resizing and show that the in vivo kinetics of growth can be recapitulated if the rate of fate commitment depends on the tissue’s stem cell proportion. Second, we develop a twodimensional simulation of the midgut and find that proportion-dependent commitment rate and stem cell scaling can arise phenomenologically from the stem cells’ exploration of physical tissue space during its lifetime. Together, these models provide a biophysical understanding of how stem cell scaling is maintained during organ growth and shrinkage.

Sign in / Sign up

Export Citation Format

Share Document