scholarly journals Age-induced apoptosis in the male genital tract of the mouse

Reproduction ◽  
2004 ◽  
Vol 127 (3) ◽  
pp. 359-366 ◽  
Author(s):  
M Jara ◽  
R Carballada ◽  
P Esponda
Keyword(s):  
Genital Tract ◽  
Caspase 3 ◽  
Ventral Prostate ◽  
Male Genital Tract ◽  
Lipofuscin Granules ◽  
Induction Of Apoptosis ◽  
Induced Apoptosis ◽  
Active Fragment ◽  
Male Genital

We have examined the effects of ageing on the increase in apoptotic cells numbers in the male genital tract of the house mouse (Mus musculus). We have found that not all organs have the same response. There is an induction of apoptosis in both the epididymis and ventral prostate. However, seminal vesicles and other prostatic lobes remain unaffected. Apoptosis was assessed by several methods: TUNEL, detection of the active fragment of caspase-3 and the pattern of DNA fragmentation on agarose gels. This increase in apoptosis is related to the fall in testosterone levels, although there is only a partial decrease in androgen receptor (AR). AR is still present in all tissues and only moderately reduced in the epididymis and ventral prostate. A more intense increase of lipofuscin granules, which may be indicative of oxidative stress, occurred in these tissues. Finally, testosterone supplementation reverses the changes (both in apoptosis and lipofuscin content in the tissue), suggesting a role of androgens in these processes.

The role of nuclear medicine in the evaluation of the male genital tract

1993 ◽  
Vol 28 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Chun Ki Kim ◽  
Lionel S. Zuckier ◽  
Abass Alavi
Keyword(s):  
Nuclear Medicine ◽  
Genital Tract ◽  
Male Genital Tract ◽  
Male Genital

scholarly journals Aquaporins Are Differentially Regulated in Canine Cryptorchid Efferent Ductules and Epididymis

Animals ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1539
Author(s):  
Caterina Squillacioti ◽  
Nicola Mirabella ◽  
Giovanna Liguori ◽  
Giuseppe Germano ◽  
Alessandra Pelagalli
Keyword(s):  
Epithelial Cells ◽  
Genital Tract ◽  
Caspase 3 ◽  
Rt Pcr ◽  
Male Genital Tract ◽  
Chain Reaction ◽  
Efferent Ductules ◽  
Pathophysiological Condition ◽  
Polymerase Chain ◽  
Male Genital

The efferent ductules and the epididymis are parts of the male reproductive system where spermatozoa mature. Specialized epithelial cells in these ducts contribute to the transport of fluids produced by spermatozoa’s metabolic activity. Aquaporins (AQPs) have been demonstrated to be expressed in the spermatozoan membrane and testis epithelial cells, where they contribute to regulating spermatozoan volume and transit through environments of differing osmolality. Due to the lack of detailed literature regarding AQP expression in the canine male genital tract, the aim of this study was to investigate both the distribution and expression of AQP7, AQP8, and AQP9 in the efferent ductules and epididymal regions (caput, corpus, and cauda) from normal and cryptorchid dogs by using immunohistochemistry, Western blotting, and real-time reverse transcription polymerase chain reaction (RT-PCR). Our results show different patterns for the distribution and expression of the examined AQPs, with particular evidence of their upregulation in the caput and downregulation in the cauda region of the canine cryptorchid epididymis. These findings are associated with a modulation of Hsp70 and caspase-3 expression, suggesting the participation of AQPs in the luminal microenvironment modifications that are peculiar characteristics of this pathophysiological condition.

Male Genital Tract Inflammation: The Role of Selected Interleukins in Regulation of Pro-Oxidant and Antioxidant Enzymatic Substances in Seminal Plasma

2003 ◽  
Vol 24 (3) ◽  
pp. 448-455 ◽  
Author(s):  
Dorota Sanocka ◽  
Piotr Jędrzejczak ◽  
Anna Szumała-Kaękol ◽  
Monika Frączek ◽  
Maciej Kurpisz
Keyword(s):  
Seminal Plasma ◽  
Genital Tract ◽  
Male Genital Tract ◽  
Male Genital
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