scholarly journals The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword

2014 ◽  
Vol 5 ◽  
Author(s):  
Kate A. Redgrove ◽  
Eileen A. McLaughlin
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Genital Tract ◽  
Male Genital Tract ◽  
Chlamydia Trachomatis Infection ◽  
Male Genital

Chlamydia trachomatis infection of the male genital tract: An update

2013 ◽  
Vol 100 (1) ◽  
pp. 37-53 ◽  
Author(s):  
Juan Pablo Mackern-Oberti ◽  
Rubén Darío Motrich ◽  
María Laura Breser ◽  
Leonardo Rodolfo Sánchez ◽  
Cecilia Cuffini ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Genital Tract ◽  
Male Genital Tract ◽  
Chlamydia Trachomatis Infection ◽  
Male Genital

scholarly journals Male genital tract immune response against Chlamydia trachomatis infection

Reproduction ◽  
2017 ◽  
Vol 154 (4) ◽  
pp. R99-R110 ◽  
Author(s):  
Juan Pablo Mackern-Oberti ◽  
Rubén Darío Motrich ◽  
Maria Teresa Damiani ◽  
Héctor Alex Saka ◽  
Cristian Andrés Quintero ◽  
...  
Keyword(s):  
Immune Response ◽  
Chlamydia Trachomatis ◽  
Epithelial Cells ◽  
Genital Tract ◽  
Host Immune Response ◽  
Innate Immune ◽  
T Helper ◽  
Male Genital Tract ◽  
Tract Infections ◽  
Male Genital

Chlamydia trachomatisis the most commonly reported agent of sexually transmitted bacterial infections worldwide. This pathogen frequently leads to persistent, long-term, subclinical infections, which in turn may cause severe pathology in susceptible hosts. This is in part due to the strategies thatChlamydia trachomatisuses to survive within epithelial cells and to evade the host immune response, such as subverting intracellular trafficking, interfering signaling pathways and preventing apoptosis. Innate immune receptors such as toll-like receptors expressed on epithelial and immune cells in the genital tract mediate the recognition of chlamydial molecular patterns. After bacterial recognition, a subset of pro-inflammatory cytokines and chemokines are continuously released by epithelial cells. The innate immune response is followed by the initiation of the adaptive response againstChlamydia trachomatis, which in turn may result in T helper 1-mediated protection or in T helper 2-mediated immunopathology. Understanding the molecular mechanisms developed byChlamydia trachomatisto avoid killing and host immune response would be crucial for designing new therapeutic approaches and developing protective vaccines. In this review, we focus on chlamydial survival strategies and the elicited immune responses in male genital tract infections.

Chlamydia trachomatis induces an inflammatory response in the male genital tract and is associated with altered semen quality

1991 ◽  
Vol 55 (5) ◽  
pp. 1017-1019 ◽  
Author(s):  
Hans Wolff ◽  
Uwe Neubert ◽  
Martin Zebhauser ◽  
Guntram Bezold ◽  
Hans Christian Korting ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Inflammatory Response ◽  
Genital Tract ◽  
Semen Quality ◽  
Male Genital Tract ◽  
Male Genital

Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures

2011 ◽  
Vol 60 (3) ◽  
pp. 307-316 ◽  
Author(s):  
Juan Pablo Mackern-Oberti ◽  
Mariana Maccioni ◽  
Maria Laura Breser ◽  
Adrian Eley ◽  
Thomas Miethke ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Chlamydia Trachomatis ◽  
Seminal Vesicle ◽  
Cell Cultures ◽  
Genital Tract ◽  
Vas Deferens ◽  
Primary Cultures ◽  
Male Genital Tract ◽  
Chemokine Production ◽  
Male Genital

Chlamydia trachomatis is an intracellular pathogen that infects mucosal epithelial cells, causing persistent infections. Although chronic inflammation is a hallmark of chlamydial disease, the proinflammatory mechanisms involved are poorly understood. Little is known about how innate immunity in the male genital tract (MGT) responds to C. trachomatis. Toll-like receptors (TLRs) are a family of receptors of the innate immunity that recognize different pathogen-associated molecular patterns (PAMPs) present in bacteria, viruses, yeasts and parasites. The study of TLR expression in the MGT has been poorly investigated. The aim of this work was to investigate the keratinocyte-derived chemokine (KC) response of MGT primary cultures from C57BL/6 mice to C. trachomatis and different PAMPs. KC production by prostate, seminal vesicle and epididymis/vas deferens cell cultures was determined by ELISA in culture supernatants. TLR2, 3, 4 and 9 agonists induced the production of KC by all MGT primary cultures assayed. In addition, we analysed the host response against C. trachomatis and Chlamydia muridarum. Chlamydial LPS (cLPS) as well as C. trachomatis and C. muridarum infection induced KC secretion by all MGT cell cultures analysed. Differences in KC levels were observed between cultures, suggesting specific sensitivity against pathogens among MGT tissues. Chemokine secretion was observed after stimulation of seminal vesicle cells with TLR agonists, cLPS and C. trachomatis. To our knowledge, this is the first report showing KC production by seminal vesicle cells after stimulation with TLR ligands, C. trachomatis or C. muridarum antigens. These results indicate that different receptors of the innate immunity are present in the MGT. Understanding specific immune responses, both innate and adaptive, against chlamydial infections, mounted in each tissue of the MGT, will be crucial to design new therapeutic approaches where innate and/or adaptive immunity would be targeted.

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