Serum concentrations of 3,5,3',5'-tetraiodothyroacetate (T4A) in subjects with hypo-, hyper- and euthyroidism

1986 ◽  
Vol 112 (2) ◽  
pp. 192-196 ◽  
Author(s):  
D. B. Ramsden ◽  
D. N. Crossley
Keyword(s):  
Human Subjects ◽  
Serum Levels ◽  
Free Thyroxine ◽  
Serum Concentrations ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Factors Influencing ◽  
The Relationship ◽  
Peripheral Metabolism

Abstract. Some factors influencing serum 3,5,3',5'-tetradiodothyroacetate (T4A) concentrations were examined in hypothyroid, euthyroid and hyperthyroid human subjects. Serum T4A concentration was shown to be correlated with parameters such as serum, total and free thyroxine (T4) concentrations and thyroxine: thyroxine binding globulin ratio, which are indicative of the availability of T4 for peripheral metabolism. The relationship between T4A and these parameters was not a simple linear one; serum levels of T4A tended to show less variation from the normal range than did serum total T4 in hyperthyroid subjects.

FAMILIAL THYROXINE-BINDING GLOBULIN DEFICIENCY IN ASSOCIATION WITH NON-TOXIC GOITRE

1979 ◽  
Vol 91 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Paul Bratusch-Marrain ◽  
Hannes Haydl ◽  
Werner Waldhäusl ◽  
Robert Dudczak ◽  
Wolfgang Graninger
Keyword(s):  
Clinical Evidence ◽  
Autosomal Dominant ◽  
Serum Concentrations ◽  
Dominant Inheritance ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
The Family ◽  
High Incidence ◽  
Total Thyroxine ◽  
Mode Of Transmission

ABSTRACT A kindred is presented in which 4 members in 3 generations showed absent or reduced serum concentrations of thyroxine-binding globulin (TBG). TBG was undetectable by radioimmunoassay in one male and decreased to varying extent in 3 female patients (4.0, 4.2 and 8.6 μg/ml; normal range 12.5–26.0 μg/ml). Total thyroxine serum concentrations in the affected subjects were well in the hypothyroid range without clinical evidence of hypothyroidism. The mode of transmission of the trait was consistent with X-chromosome linkage. A high incidence of non-toxic goitre was also present in most of the family members examined irrespective of TBG levels. The transmission of the goitre trait was compatible with autosomal dominant inheritance. Thus its association with transmission of TBG deficiency was interpreted as not causal but coincidental.

EFFECTS OF CHRONIC RENAL DISEASE ON THYROID HORMONE METABOLISM

1977 ◽  
Vol 84 (4) ◽  
pp. 750-758 ◽  
Author(s):  
J. F. Finucane ◽  
R. S. Griffiths ◽  
E. G. Black ◽  
C. L. Hall
Keyword(s):  
Renal Disease ◽  
Chronic Renal Disease ◽  
Normal Subjects ◽  
Free Thyroxine ◽  
Poor Correlation ◽  
Serum Concentrations ◽  
Hormone Metabolism ◽  
Normal Range ◽  
Thyroid Hormone Metabolism ◽  
Urine Concentrations

ABSTRACT Serum concentrations of total and free thyroxine and triiodothyronine together with urine losses of unconjugated thyroid hormones have been measured in normal subjects and in patients with renal disease. Serum total hormone values in the hypothyroid range were common in the renal group and correlated inversely with the degree of renal impairment but not with renal loss of hormone which in the case of thyroxine exceeded the average normal daily loss ten-fold. The euthyroid state of patients with renal disease was best reflected by serum free thyroxine concentration which in every case was within the normal range. Poor correlation was apparent between the respective urine concentrations of albumin and thyroxine, and the reasons for this are discussed.

THE EFFECT OF COAGULATIOU CHANGES ON THE OUTCOME OF GASTROINTESTINAL HAEMORRHAGE

1987 ◽  
Author(s):  
S D Blair ◽  
K K Tan ◽  
C N McCollum ◽  
R M Greenhalgh
Keyword(s):  
Blood Transfusion ◽  
Clinical Outcome ◽  
Vascular Disease ◽  
Cause Of Death ◽  
Gastrointestinal Haemorrhage ◽  
Mortality Rates ◽  
Clotting Time ◽  
Normal Range ◽  
Factors Influencing ◽  
The Relationship

Blood is hypercoagulable following GI haemorrhage [1], and vascular thrombosis has been reported to be the main cause of death [2]. To study the relationship between coagulation and clinical outcome, Impedance Clotting Time (ICT) wac measured daily using the Biobridge [1] and clinical outcome prospectively recorded in 125 patients with acute severe GI haemorrhage.Mean (±se mean) ICT on admission was markedly shortened at 4.8±0.2 mins (normal range 8-12 mins) (p<0.001, t-Cest). Sixty patients received blood transfusion within 24 hours resulting in significantly prolonged ICT of 6.2±0.4 mins compared to 4.0±0.3 mins in the 56 not transfused (p<0.01). In 23 patients who rebled, the ICT at 24 hours of 6.7±0.4 mins demonstrated reduced hypercoagulability. Twenty of these 23 patients had bee:: transfused prior to rebleeding, a significantly greater proportion than in those who did not rebleed (p<0.00l). Six patients died, 3 of myocardial infarction, 1 of stroke, and 2 of continued haemorrhage. Mean ICT in the 4 patients dying from thrombotic vascular disease was 2.3±0.1 mins although 2 had also rebled.Clinical outcome in GI haemorrhage is strongly related to coagulation changes. The main cause of death was thrombotic vascular disease.1. Blair SD, Janvrin SB, McCollum CN, Greenhalgh RM. The effect of early blood transfusion on gastrointectinal haemorrhage. Br J Surg 1986; 73: 792-4.2. Allan R, Dykes P. A study of the factors influencing mortality rates fron gastrointestinal haenorrhage. Quart JMed 1976; 180: 533-50.

Absence of circulating desialylated thyroxine-binding globulin in patients with hepatobiliary disease

1985 ◽  
Vol 108 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Giuseppe Costante ◽  
Georges Sand ◽  
Pierre Reding ◽  
Daniel Glinoer
Keyword(s):  
Liver Disease ◽  
Elevated Serum ◽  
Serum Levels ◽  
Carrier Protein ◽  
Thyroxine Binding Globulin ◽  
Diseased Liver ◽  
Wide Scatter ◽  
Hepatobiliary Diseases ◽  
Peripheral Metabolism

Abstract. Thyroxine-binding globulin (TBG) is the major thyroid hormone carrier protein. The molecule contains approximately 10 sialic acid residues which play a key role in the peripheral metabolism of TBG. Since the serum of patients with liver disease often contains large amounts of several desialylated glycoproteins, the aim of the present studies was to characterize circulating TBG and to examine the possible presence of desialylated TBG (dTBG) in 24 patients with a variety of hepatobiliary diseases and selected on the basis of elevated serum levels of desialylated glycoproteins. Using 4 immunochemical techniques applied for the measurement of TBG, for the detection of dTBG and for the characterization of TBG microheterogeneity, the results indicated: a) a wide scatter of serum TBG levels between 4 and 23 mg/l; b) the absence of detectable amounts of dTBG in any of the sera tested; and c) a close similarity between the microheterogeneity of TBG in patients with liver disease with that of control sera or of purified TBG. In conclusion, in patients with acute and chronic liver disease, TBG, although quantitatively modified, remains qualitatively unaltered, suggesting that diseased liver produces fully sialylated TBG and that its catabolism is not impaired.

Serum Levels of Some Micronutrients and Congenital Malformations: A Prospective Cohort Study in Healthy Saudi-Arabian First-Trimester Pregnant Women

2013 ◽  
Vol 83 (6) ◽  
pp. 346-354 ◽  
Author(s):  
Sahar A. Ibrahim Hammouda ◽  
Om Alsaad Farouk Abd Al-Halim ◽  
Ahmed M. Mohamadin
Keyword(s):  
Pregnant Women ◽  
Congenital Malformations ◽  
Saudi Arabian ◽  
Serum Levels ◽  
First Trimester ◽  
Serum Concentrations ◽  
Vitamin Deficiencies ◽  
The Relationship ◽  
The City ◽  
Health Care Centers

Background/Objectives: Various studies have linked vitamin deficiencies in early pregnancy with birth defects. The objective of this study was to identify the relationship between micronutrient deficiency and congenital malformations (CM). Subjects and Methods: There were 1,180 healthy, first-trimester pregnant Saudi-Arabian females selected from the antenatal care clinics of two hospitals and 21 health care centers located all over the city. Their full medical history, clinical examination, anthropometry, and various laboratory analyses were completed. Results: Forty-eight infants were born with CM. The serum concentrations of the analyzed nutrients (selenium, zinc, magnesium, and vitamins A, E, B12, and folic acid) were significantly lower in mothers of infants with CM compared to the mothers of infants without CM. In comparison, the serum totals of homocysteine (tHcy) levels were significantly higher among the CM group. Conclusion: This study highlights the association of CM with the deficiency of certain vitamins and minerals among pregnant women.

scholarly journals The Relationship Between CRP Gene Polymorphism and the Serum Concentrations of C-Reactive Protein, Total Cholesterol and HDL Cholesterol in Suckling Piglets / Związek polimorfizmu genu CRP z koncentracją kodowanego białka C-reaktywnego, cholesterolu całkowitego i HDL-ch w surowicy krwi ssących prosiąt

2013 ◽  
Vol 13 (3) ◽  
pp. 503-512 ◽  
Author(s):  
Marek Łaszyn ◽  
Hanna Sielawa ◽  
Krystyna Życzko
Keyword(s):  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Large White ◽  
Reactive Protein ◽  
Suckling Piglets ◽  
The Relationship

AbstractThe relationship between CRP gene (1271 G/A, 3’UTR) polymorphism and the serum levels of C-reactive protein (CRP), total cholesterol (Ch-T) and high density lipoprotein cholesterol (HDL-ch) was analysed in suckling crossbred [Polish Large White × Polish Landrace (♀) × × Duroc × Pietrain (♂)] piglets. CRP genotypes were identified by PCR-RFLP with Hinfi restriction enzyme. The levels of CRP, Ch-T, HDL-ch and white blood cell (WBC) counts were determined in blood samples collected from younger (21±3 days of age) and older piglets (35±3 days of age). There was a relationship between CRP gene (1271 G/A, 3’UTR) polymorphism and variations in the serum levels of CRP in piglets with normal WBC counts. The above relationship did not manifest itself in piglets with elevated WBC counts. The studied genotypes differed in their response to elevated WBC counts, and the noted differences were more pronounced in older piglets. The response of genotypes with weak CRP expression caused an increase in CRP levels and a decrease in the serum concentrations of Ch-T and HDL-ch. Such a response was not observed in the genotype with strong CRP expression.

Effects of iodotyrosine deiodinase inhibition on serum concentrations and turnover of diiodotyrosine (DIT) and thyroxine (T4) in the rat

1983 ◽  
Vol 103 (4) ◽  
pp. 521-527 ◽  
Author(s):  
Harald Meinhold ◽  
Reinhard Buchholz
Keyword(s):  
Turnover Rate ◽  
Human Subjects ◽  
Fold Increase ◽  
Serum Levels ◽  
Metabolic Clearance ◽  
Serum Concentrations ◽  
Iodotyrosine Deiodinase ◽  
Normal Rat ◽  
Tracer Kinetic ◽  
Normal Human

Abstract. Serum concentrations and metabolic clearance rates (MCR) of diiodotyrosine (DIT) and thyroxine (T4) have been measured by radioimmunoassay and tracer kinetic technique in both normal rats and rats treated with 3-nitro-l-tyrosine (MNT), a potent inhibitor of iodotyrosine deiodinase. In normal rats, DIT serum levels were 0.27 ± 0.12 nmol/l (mean ± sd); MCR was 15.9 ml/h 100 · g body weight (bw), and the turnover rate was 4.3 pmol/h · 100 g bw. Inhibition of iodotyrosine deiodination by treatment with 50 μmol MNT per day for 1 week caused a highly significant elevation of DIT serum levels to 4.80 ± 3.30 nmol/l, a decrease of MCR to 9.0 ml/h · 100 g bw and a ten-fold increase of the DIT turnover rate to 43.2 pmol/h · 100 g bw. Serum concentrations of T4 and T3 decreased slightly, whereas the T4 turnover rate (37.5 vs 37.8 pmol/h · 100 g bw) and rT3 serum levels remained unchanged under MNT treatment. The study demonstrates the presence of measurable DIT serum concentrations in the normal rat. Inhibition of intra- and extrathyroidal iodotyrosine deiodinase leads to a situation in which circulating iodotyrosines play an equally important role in peripheral iodine turnover as the iodothyronines. Since DIT serum levels in normal and enzyme-blocked rats were comparable to those in normal human subjects and patients with iodotyrosine deiodinase defect respectively, MNT-treated rats afford a suitable experimental model for this disease.

INHERITED DECREASE OF THE BINDING CAPACITY OF THYROXINE-BINDING GLOBULIN (TBG)

1970 ◽  
Vol 64 (1) ◽  
pp. 171-180 ◽  
Author(s):  
O. P. Heinonen ◽  
B.-A. Lamberg ◽  
J. Virtamo
Keyword(s):  
Autosomal Dominant ◽  
Binding Capacity ◽  
Normal Subjects ◽  
Free Thyroxine ◽  
Gradual Change ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
The Difference ◽  
Factor Governing ◽  
Mode Of Inheritance

ABSTRACT A family with a decrease in the binding capacity of thyroxine binding globulin (TBG) is described. The gene was probably transmitted by a female who married twice. Five subjects were considered TBG deficient, with TBG values ranging from 8.4 to 16.8 μg/100 ml. Of these subjects 2 were males and 3 females; the males had the lowest binding capacities. In addition, 1 male and 3 females had TBG values within the low normal range and were considered as possibly affected. The mode of inheritance could not be exactly defined but there were indications that it might be an autosomal dominant. The correlation of TBG to the protein-bound iodine in the serum (PBI), to the triiodothyronine uptake by Sephadex (T3-U), to the ratio between them (T3-U/PBI), and to the proportionate free thyroxine (PFT4) was strongly positive or negative. A gradual change in these variables from the affected to the unaffected subjects was observed. These correlations indicated that in normal subjects TBG is the most important factor governing the PBI and free thyroxine levels. In addition, a strong inverse and statistically significant correlation was observed between the binding capacity of TBG and that of the pre-albumin (TPBA). The difference between affected and unaffected subjects with regard to TPBA was also statistically significant.

CHANGES IN SERUM LEVELS OF THYROXINE AND THYROXINE-BINDING PROTEINS (TBG, TBPA, ALBUMIN) INDUCED BY VENOUS STASIS

1977 ◽  
Vol 85 (1) ◽  
pp. 39-43 ◽  
Author(s):  
B. Brock Jacobsen ◽  
B. Petersen ◽  
H. Andersen
Keyword(s):  
Constant Pressure ◽  
Haemoglobin Concentration ◽  
Serum Levels ◽  
Venous Stasis ◽  
Total Serum ◽  
Serum Concentrations ◽  
Thyroxine Binding Globulin ◽  
Venous Compression ◽  
Before And After ◽  
Young Subjects

ABSTRACT Serum concentrations of thyroxine (T4), thyroxine-binding globulin (TBG), thyroxine-binding pre-albumin (TBPA) and albumin were determined in 21 healthy, young subjects before and after a brief venous stasis in two experiments: 1) 3 min stasis induced by a sphygmomanometer with constant pressure 20 mmHg above the diastolic blood pressure and 2) 2 min stasis induced by an arm tourniquet of rubber. In both experiments the serum T4 level was significantly rised (mean 9 %) after venous compression. Increases of the same magnitude were observed for serum TBG, serum TBPA and serum albumin. The serum concentrations of the free constituents - sodium and creatinine - remained unchanged, whereas the haemoglobin concentration increased (mean 8%). This haemoconcentrating effect of venous stasis seemed to be more pronounced in females than in males. Our data emphasize the need for protein correction procedures when total serum T4 is measured.

Transient Prealbumin- Associated Hyperthyroxinemia in TSH-Producing Pituitary Adenoma

1990 ◽  
Vol 29 (01) ◽  
pp. 40-43 ◽  
Author(s):  
W. Langsteger ◽  
P. Költringer ◽  
P. Wakonig ◽  
B. Eber ◽  
M. Mokry ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Pituitary Adenoma ◽  
Thyroid Hormones ◽  
Protein Binding ◽  
Alpha Subunit ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Free Thyroid Hormones ◽  
Transmission Computed Tomography

This case report describes a 38-year-old male who was hospitalized for further clarification of clinically mild hyperthyroidism. His increased total hormone levels, the elevated free thyroid hormones and the elevated basal TSH with blunted response to TRH strongly suggested a pituitary adenoma with inappropriate TSH incretion. Transmission computed tomography showed an intrasellar expansion, 16 mm in diameter. The neoplastic TSH production was confirmed by an elevated alpha-subunit and a raised molar alpha-sub/ATSH ratio. However, T4 distribution on prealbumin (PA, TTR), albumin (A) and thyroxine binding globulin (TBG) showed a clearly increased binding to PA (39%), indicating additional prealbumin-associated hyperthyroxinemia. The absolute values of PA, A and TBG were within the normal range. After removal of the TSH-producing adenoma, basal TSH, the free thyroid hormones and T4 binding to prealbumin returned to normal. Therefore, the prealbumin-associated hyperthyroxinemia had to be interpreted as a transitory phenomenon related to secondary hyperthyroidism (T4 shift from thyroxine binding globulin to prealbumin) rather than a genetically conditioned anomaly of protein binding.

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