CHANGES IN SERUM LEVELS OF THYROXINE AND THYROXINE-BINDING PROTEINS (TBG, TBPA, ALBUMIN) INDUCED BY VENOUS STASIS

1977 ◽  
Vol 85 (1) ◽  
pp. 39-43 ◽  
Author(s):  
B. Brock Jacobsen ◽  
B. Petersen ◽  
H. Andersen
Keyword(s):  
Constant Pressure ◽  
Haemoglobin Concentration ◽  
Serum Levels ◽  
Venous Stasis ◽  
Total Serum ◽  
Serum Concentrations ◽  
Thyroxine Binding Globulin ◽  
Venous Compression ◽  
Before And After ◽  
Young Subjects

ABSTRACT Serum concentrations of thyroxine (T4), thyroxine-binding globulin (TBG), thyroxine-binding pre-albumin (TBPA) and albumin were determined in 21 healthy, young subjects before and after a brief venous stasis in two experiments: 1) 3 min stasis induced by a sphygmomanometer with constant pressure 20 mmHg above the diastolic blood pressure and 2) 2 min stasis induced by an arm tourniquet of rubber. In both experiments the serum T4 level was significantly rised (mean 9 %) after venous compression. Increases of the same magnitude were observed for serum TBG, serum TBPA and serum albumin. The serum concentrations of the free constituents - sodium and creatinine - remained unchanged, whereas the haemoglobin concentration increased (mean 8%). This haemoconcentrating effect of venous stasis seemed to be more pronounced in females than in males. Our data emphasize the need for protein correction procedures when total serum T4 is measured.

Iodothyronine deiodination in rats with severe non-thyroidal illness

1988 ◽  
Vol 118 (1) ◽  
pp. 31-37 ◽  
Author(s):  
M. Grussendorf ◽  
G. Wollensack ◽  
M. Hüfner
Keyword(s):  
Serum Levels ◽  
Total Serum ◽  
Serum Concentrations ◽  
Tumor Implantation ◽  
Tumor Bearing ◽  
Before And After ◽  
Measurable Serum ◽  
Male Wistar Rats ◽  
Liver Homogenates

Abstract. To investigate the iodothyronine metabolism in non-thyroidal illness (NTI), thyroidectomized male Wistar rats bearing the hypercalcemic Walker sarcoma 256 were substituted with, respectively, 2.3 and 11.5 μmol T4/100 g body weight by daily ip injection. Serum T4 and T3 concentrations of euthyroid and hyperthyroid tumor-bearing animals markedly decreased to a nadir at day 8 after tumor implantation: serum T4 fell to, respectively, 43% (euthyroid) and 26% (hyperthyroid) of initial values, serum T3 to 19% (euthyroid) and 26% (hyperthyroid). A measurable serum rT3 concentration could not be detected before and after tumor implantation. In vitro deiodination of T4 to T3 in liver homogenates of the sacrificed animals was not significantly reduced in Walker rats compared with control animals. The activity of T4 deiodinase was significantly induced in hyperthyroid controls (180%) as well as in hyperthyroid Walker rats (155%) in spite of low serum concentrations of T4 and T3. This enzyme induction was even more pronounced in animals whose treatment with high T4 doses was started after tumor implantation. In these rats the serum concentrations of free fatty acids were increased to about 200% of controls. Our data suggest that 1. the fluctuations of iodothyronine serum concentrations in NTI are mainly independent of thyroidal secretion, and 2. the intracellular iodothyronine levels in livers of severely sick animals with different thyroid function are not greatly altered by NTI, in spite of markedly decreased total serum levels.

scholarly journals Serum Adiponectin Levels in Advanced-Stage Parkinson's Disease Patients

2011 ◽  
Vol 2011 ◽  
pp. 1-6
Author(s):  
Erica Cassani ◽  
Raffaella Cancello ◽  
Ferruccio Cavanna ◽  
Sabrina Maestrini ◽  
Anna Maria Di Blasio ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cardiovascular Risk ◽  
Body Weight Loss ◽  
Serum Levels ◽  
Normal Weight ◽  
Morbidly Obese ◽  
Serum Concentrations ◽  
Status Assessment ◽  
Young Subjects

Patients with advanced Parkinson's disease (PD) experience body weight loss and reductions in the most common cardiovascular risk factors. At present, the pathogenetic mechanisms involved have not been elucidated. Increased serum concentrations of adiponectin, which possesses antiatherogenic and anti-inflammatory properties, are associated with a reduction in cardiovascular risk. The objective of this study was to determine adiponectin serum concentrations in PD patients. Thirty PD patients underwent a full nutritional status assessment, including the determination of adiponectin serum concentrations. Mean ± SD adiponectin concentrations were 9.59 ± 5.9 μg/mL (interquartile range: 5.92–12.9 μg/mL). In PD patients, adiponectin serum levels were similar to those in normal-weight, healthy, young subjects and significantly higher than that in an aged-matched group of morbidly obese subjects. Further studies are warranted to establish the role of adiponectin in the management of PD patients.

Altered serum levels of thyroxine, triiodothyronines and diiodothyronines in endogenous depression

1981 ◽  
Vol 96 (2) ◽  
pp. 199-207 ◽  
Author(s):  
C. Kirkegaard ◽  
J. Faber
Keyword(s):  
Similar Pattern ◽  
Serum Levels ◽  
Endogenous Depression ◽  
Serum Concentrations ◽  
Electroconvulsive Treatment ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Before And After ◽  
Altered Serum

Abstract. Serum levels of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2), 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) were studied in 80 patients with endogenous depression before and after electroconvulsive treatment (ECT). Compared to the values found after recovery, the patients when depressed had significant increased serum levels of T4, rT3, 3,3'-T2 and 3',5'-T2. Serum concentrations of T3 and 3,5-T2 were not significantly altered. Similarly the free T4 index (FT4I) was increased, while the free T3 index (FT3I) was unaffected. Previous studies have shown a reduced TSH response to TRH in patients with endogenous depression and that the long-term outcome after ECT is strongly related to changes in the TSH response. However, patients with increased TSH response to TRH (n = 23) had a pattern of serum iodothyronine concentrations similar to those (n = 57) with an unchanged TSH response. A similar pattern was also found in 7 patients with non-endogenous psychosis, in whom the TSH response to TRH was unchanged after recovery. It is concluded that the alterations of the TSH response to TRH found in endogenous depression cannot be explained by changes of FT4I or FT3I.

scholarly journals Concentration of Serum Thyroid Hormone Binding Proteins after 131I Treatment of Hyperthyroidism

1981 ◽  
Vol 18 (4) ◽  
pp. 211-214 ◽  
Author(s):  
John S Harrop ◽  
Malcolm R Hopton ◽  
John H Lazarus
Keyword(s):  
Thyroid Hormone ◽  
Binding Proteins ◽  
Response To Treatment ◽  
Serum Concentrations ◽  
Hormone Binding ◽  
Thyroxine Binding Globulin ◽  
131I Treatment ◽  
Before And After ◽  
Hormone Binding Protein ◽  
Serum Thyroid Hormone

Serum concentrations of the thyroid hormone binding proteins, thyroxine binding globulin, prealbumin, and albumin were determined in 30 thyrotoxic patients before and after 131I treatment. Each patient was placed into one of three groups according to response to treatment. The serum concentration of all three proteins rose significantly in 10 patients who became euthyroid, and a greater increase was seen in 10 patients who developed hypothyroidism. There was no significant change in thyroid hormone binding protein concentrations in 10 subjects who remained hyperthyroid. Changes in the concentration of thyroid hormone binding proteins should be borne in mind when total thyroid hormone concentrations are used to monitor the progress of patients receiving treatment for hyperthyroidism.

Serum concentrations of 3,5,3',5'-tetraiodothyroacetate (T4A) in subjects with hypo-, hyper- and euthyroidism

1986 ◽  
Vol 112 (2) ◽  
pp. 192-196 ◽  
Author(s):  
D. B. Ramsden ◽  
D. N. Crossley
Keyword(s):  
Human Subjects ◽  
Serum Levels ◽  
Free Thyroxine ◽  
Serum Concentrations ◽  
Normal Range ◽  
Thyroxine Binding Globulin ◽  
Factors Influencing ◽  
The Relationship ◽  
Peripheral Metabolism

Abstract. Some factors influencing serum 3,5,3',5'-tetradiodothyroacetate (T4A) concentrations were examined in hypothyroid, euthyroid and hyperthyroid human subjects. Serum T4A concentration was shown to be correlated with parameters such as serum, total and free thyroxine (T4) concentrations and thyroxine: thyroxine binding globulin ratio, which are indicative of the availability of T4 for peripheral metabolism. The relationship between T4A and these parameters was not a simple linear one; serum levels of T4A tended to show less variation from the normal range than did serum total T4 in hyperthyroid subjects.

Antagonism of serum tri-iodothyronine changes after injections of prolactin in the domestic fowl before and after hatching

1983 ◽  
Vol 99 (3) ◽  
pp. 401-407 ◽  
Author(s):  
E. R. Kühn ◽  
E. Decuypere ◽  
K. Hemschoote ◽  
L. Berghman ◽  
J. Paulussen
Keyword(s):  
Thyroid Gland ◽  
Rhode Island ◽  
Domestic Fowl ◽  
Chronic Administration ◽  
Serum Levels ◽  
Serum Concentrations ◽  
Before And After ◽  
Thyroid Metabolism ◽  
Ovine Prolactin ◽  
Circulating Levels

The influence of an intravenous injection of ovine prolactin on circulating levels of thyroid hormones was studied in Rhode Island Red embryos and chicks after hatching. In the chick embryo, 2 h after injection of 0·1 μg prolactin (on incubation day 19), serum tri-iodothyronine (T3) increased threefold; after 10 or 100 μg prolactin (on incubation day 18) serum T3 increased 15- to 25-fold. These profound increases were not observed in chicks after hatching. Serum concentrations and thyroid content of thyroxine (T4) in embryos and chicks of all ages studied were not influenced by the prolactin injections. Maximal serum concentrations of reverse T3 (rT3) were found on incubation day 18 (110·25 ± 23·36 pmol/l; 71·66 ± 15·18 pg/ml; n = 8), whereas after hatching no rT3 could be detected. An injection of 10 μg prolactin on day 18 depressed serum rT3 after 2 h to 5·68 ± 3·20 pmol/l (3·69 ± 2·08 pg/ml; n = 8; P<0·001); the effect of 100 μg prolactin was less pronounced. After hatching, chronic administration of prolactin resulted in decreased serum levels of T3, but not of T4, and hypertrophy of the follicles in the thyroid gland. It is concluded that prolactin plays a major role in the maturation of embryonic thyroid metabolism by changing the T4-5-monodeiodination into a T4-5′-monodeiodination. The hypertrophy of the thyroid gland observed after hatching following prolonged prolactin administration may be due to decreased negative feedback of T3 on the hypophysis.

Effect of iodide treatment on iodine concentration and volume of endemic non-toxic goitre in childhood

1985 ◽  
Vol 108 (1) ◽  
pp. 44-50 ◽  
Author(s):  
B. Leisner ◽  
B. Henrich ◽  
D. Knorr ◽  
R. Kantlehner
Keyword(s):  
Thyroid Volume ◽  
Iodine Concentration ◽  
Thyroxine Binding Globulin ◽  
X Ray ◽  
Thyroxine Therapy ◽  
Iodine Supplementation ◽  
Before And After ◽  
The Mean ◽  
Young Subjects ◽  
Normal Controls

Abstract. In a total of 195 children and adolescents of both sex (mean age 12.9, range 5–17 years) with endemic non-toxic goitre the thyroidal iodine concentration (IC) was determined using X-ray fluorescent scanning on admission and during iodine (100 μg daily) and l-thyroxine (3 μg/kg body weight daily) treatment respectively. Additionally the thyroid volume was measured sonographically in a longitudinal study including 46 patients before and after 4–8 months of iodine supplementation (100 μg daily). The IC was 305 ± 144 μg/g. It compared well with that of adult goitre patients (288 ± 109 μg/g) and was significantly inferior to the value of normal controls (389 ± 170 μg/g). Under l-thyroxine therapy the IC further decreased (243 ± 144 μg/g), whereas patients receiving iodide showed an increase of the IC (570 ± 197 μg/g). The mean TSH level fell from 2.3 ± 0.9 μU/ml to 1.4 ± 0.6 μU/ml. The average T4/TBG (thyroxine binding globulin) ratio showed a slight increase which, however, was not significant. The mean goitre volume decreased by 40%. It was evidenced that iodide is useful not only in the prophylaxis of non-toxic goitre but also as a more physiologic treatment than thyroid hormones, at least for young subjects with simple diffuse goitres.

scholarly journals CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis Patients

Toxins ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 324
Author(s):  
Yasutoshi Akiyama ◽  
Koichi Kikuchi ◽  
Takafumi Toyohara ◽  
Eikan Mishima ◽  
Chitose Suzuki ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Chronic Kidney Disease ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Patient Specific ◽  
Serum Concentrations ◽  
Ckd Stage ◽  
Before And After ◽  
Uremic Solutes ◽  
Ionic Solutes

Uremic toxins are suggested to be involved in the pathophysiology of hemodialysis (HD) patients. However, the profile of uremic solutes in HD patients has not been fully elucidated. In this study using capillary electrophoresis mass spectrometry (CE-MS), we comprehensively quantified the serum concentrations of 122 ionic solutes before and after HD in 11 patients. In addition, we compared the results with those in non-HD patients with chronic kidney disease (CKD) to identify HD patient-specific solutes. We identified 38 solutes whose concentrations were higher in pre-HD than in CKD stage G5. Ten solutes among them did not significantly accumulate in non-HD CKD patients, suggesting that these solutes accumulate specifically in HD patients. We also identified 23 solutes whose concentrations were lower in both pre- and post-HD than in CKD stage G5. The serum levels of 14 solutes among them were not affected by renal function in non-HD patients, suggesting that these solutes tend to be lost specifically in HD patients. Our data demonstrate that HD patients have a markedly different profile of serum uremic solute levels compared to that in non-HD CKD patients. The solutes identified in our study may contribute to the pathophysiology of HD patients.

scholarly journals Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Violeta Lokaj-Berisha ◽  
Besa Gacaferri Lumezi ◽  
Naser Berisha
Keyword(s):  
Serum Testosterone ◽  
Allergic Diseases ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Total Serum ◽  
Control Group ◽  
Total Testosterone ◽  
Serum Concentrations ◽  
Female Patients ◽  
Subject Selection

AbstractEvidence from several unrelated animal models and some studies conducted in humans, points to the immunomodulatory effects of androgens on various components of the immune system, especially on allergic disorders. This study evaluated the serum concentrations of sex hormones in women with allergy. For this purpose, blood samples were obtained from 78 participants in order to detect serum IgE concentrations, total testosterone, estradiol, progesterone, and DHEA-S. The majority of the subjects (54) in the study were consecutive patients with doctor-diagnosed allergic pathologies: 32 with allergic rhinitis, 10 with asthma and rhinitis, and 12 with skin allergies. In addition, 24 healthy volunteers were included in the research as the control group. The average age of the subjects was 32.54 years (SD ± 11.08 years, range between 4–59 years). All participants stated that they had not used any medical treatment to alleviate any of their symptoms prior to taking part in the research. They all underwent skin-prick tests for common aero-allergens, which was used as criterion for subject selection. Hence, the subjects were selected if they reacted positively to at least one aero-allergen. Their height and weight were measured in order to calculate the BMI. As a result, statistically significant differences between controls and allergic women in serum concentrations of androgens (testosterone, p = 0.0017; DHEA-S, p = 0.04) were found, which lead to the conclusion that the concentration of total serum testosterone and DHEA-S was lower in female patients with allergic diseases compared to controls.

scholarly journals Role of periostin in evaluating the responsiveness of allergic patients to allergen-specific immunotherapy

2022 ◽  
Vol 21 (1) ◽  
pp. 184-190
Author(s):  
Nashwa M Selim ◽  
Somia El Sheikh ◽  
Wafaa S Metwally
Keyword(s):  
Specific Immunotherapy ◽  
Medical Science ◽  
Serum Levels ◽  
Total Serum ◽  
Serum Samples ◽  
Allergen Specific Immunotherapy ◽  
Prick Test ◽  
Symptom Scores ◽  
Before And After ◽  
One Year

Objectives: Allergen-specific immunotherapy (AIT) has been considered the most effective treatment for IgE mediated allergies, especially respiratory allergies. Several biomarkers have been developed to evaluate the clinical efficacy of AIT, yet none of them have been thoroughly validated. So our objective here is to investigate the usefulness of periostin as a biomaker for monitoring the efficacy of allergen immunotherapy. Materials and methods: This study included 46 healthy non-atopic volunteers and 46 patients with allergic rhinitis (AR). They were sensitized only to date palm pollen. The participants were tested by skin prick test and total serum IgE levels were measured. Serum samples were collected from healthy subjects and allergic patients before and after the one-year AIT. Serum levels of periostin, eotaxin, and sIL-2R were estimated by ELISA. Symptom scores in the allergic patients were also evaluated before and after completing one year AIT. Results: There is a significant increase in serum levels of IgE, periostin, sIL-2R, and eotaxin in allergic patients as compared to healthy controls. Symptom scores, sIL-2R and serum periostin levels were significantly decreased after one-year AIT in AR patients. Conclusion: Periostin can be used as a biomarker to evaluate AIT efficacy in AR patients. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 184-190

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