Altered serum levels of thyroxine, triiodothyronines and diiodothyronines in endogenous depression

1981 ◽  
Vol 96 (2) ◽  
pp. 199-207 ◽  
Author(s):  
C. Kirkegaard ◽  
J. Faber
Keyword(s):  
Similar Pattern ◽  
Serum Levels ◽  
Endogenous Depression ◽  
Serum Concentrations ◽  
Electroconvulsive Treatment ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Before And After ◽  
Altered Serum

Abstract. Serum levels of thyroxine (T4), 3,3',5-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2), 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) were studied in 80 patients with endogenous depression before and after electroconvulsive treatment (ECT). Compared to the values found after recovery, the patients when depressed had significant increased serum levels of T4, rT3, 3,3'-T2 and 3',5'-T2. Serum concentrations of T3 and 3,5-T2 were not significantly altered. Similarly the free T4 index (FT4I) was increased, while the free T3 index (FT3I) was unaffected. Previous studies have shown a reduced TSH response to TRH in patients with endogenous depression and that the long-term outcome after ECT is strongly related to changes in the TSH response. However, patients with increased TSH response to TRH (n = 23) had a pattern of serum iodothyronine concentrations similar to those (n = 57) with an unchanged TSH response. A similar pattern was also found in 7 patients with non-endogenous psychosis, in whom the TSH response to TRH was unchanged after recovery. It is concluded that the alterations of the TSH response to TRH found in endogenous depression cannot be explained by changes of FT4I or FT3I.

Cervicogenic dizziness – musculoskeletal findings before and after treatment and long-term outcome

2007 ◽  
Vol 29 (15) ◽  
pp. 1193-1205 ◽  
Author(s):  
Eva-Maj Malmström ◽  
Mikael Karlberg ◽  
Agneta Melander ◽  
Måns Magnusson ◽  
Ulrich Moritz
Keyword(s):  
Term Outcome ◽  
Long Term Outcome ◽  
Before And After ◽  
Cervicogenic Dizziness

Diagnosis, Personality and the Long-term Outcome of Depression

1990 ◽  
Vol 157 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Gavin Andrews ◽  
Megan Neilson ◽  
Caroline Hunt ◽  
Gavin Stewart ◽  
L. G. Kiloh
Keyword(s):  
Endogenous Depression ◽  
Index Admission ◽  
Term Outcome ◽  
Long Term Outcome

Patients diagnosed in the late 1960s as suffering from either endogenous or neurotic depression, or as presenting with depression but discharged with another neurotic diagnosis, were followed for 15 years. Diagnosis at index admission did not predict overall outcome, but patients with endogenous depression, an apparently stable diagnosis, had longer index admissions, were readmitted sooner, but spent less time ill than patients in either of the neurosis groups. Personality abnormality accounted for 20% of the variance in outcome in the neurotic groups and only 2% of the variance in the endogenous group. Thus there is evidence that endogenous and neurotic depression are two illnesses and that, in the neuroses particularly, prognosis will depend on the extent to which these personality abnormalities are modified by treatment.

Malignancies before and after Heart Transplantation - A Single-Centre Long-Term Outcome Study

2021 ◽  
Vol 40 (4) ◽  
pp. S242-S243
Author(s):  
C.F. Stenman ◽  
A. Wallinder ◽  
E. Holmberg ◽  
K. Karason ◽  
J. Magnusson ◽  
...  
Keyword(s):  
Heart Transplantation ◽  
Outcome Study ◽  
Single Centre ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Before And After

scholarly journals Balloon-mounted stenting for ICAS in a multicenter registry study in China: a comparison with the WEAVE/WOVEN trial

2020 ◽  
pp. neurintsurg-2020-016658
Author(s):  
Kaijiang Kang ◽  
Yong Zhang ◽  
Jie Shuai ◽  
Changchun Jiang ◽  
Qiyi Zhu ◽  
...  
Keyword(s):  
Registry Study ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Arterial Access ◽  
Stent Restenosis ◽  
Atherosclerotic Stenosis ◽  
Before And After ◽  
Intracranial Artery Stenosis ◽  
Multicenter Registry

BackgroundThe outcome of deploying balloon-mounted stents for symptomatic intracranial atherosclerotic stenosis (ICAS) has not been fully investigated. In this study we evaluate the safety and long-term outcome of using balloon-mounted stents to treat symptomatic ICAS in comparison with the WEAVE/WOVEN study.MethodsIn a multicenter registry study of stenting for symptomatic intracranial artery stenosis in China, 159 patients treated with an intracranial balloon-mounted stent approved by the China Food and Drug Administration were evaluated. The morphological features of the lesions were categorized by Mori classification. The endpoints, including periprocedural and long-term clinical and radiological outcomes, were the same as those in the WEAVE/WOVEN study.ResultsIn the present study the mean percent stenosis before and after stenting was 84.0% and 6.1%, respectively. The proportions of Mori A, Mori B, and Mori C lesions were 33.3%, 52.2%, and 14.5%, respectively. The 72-hour rates of stroke and mortality after the procedure were 0%. The 1-year rates of any stroke, ischemic stroke, hemorrhagic stroke, and death were 6.3% (10/159), 5.7% (9/159), 0.6% (1/159), and 0.6% (1/159), respectively. The 1-year rate of in-stent restenosis (ISR) was 23.4% (15/64). The rate of ISR in Mori C lesions (53.8%, 7/13) was significantly higher than that in Mori A (15.8%, 3/19) or Mori B lesions (15.6%, 5/32) (p=0.024).ConclusionsThe short-term and long-term outcomes of using a balloon-mounted stent for symptomatic ICAS with focal and non-angular lesions (Mori A and B type) and smooth arterial access were comparable to the results of the WEAVE/WOVEN trial.

scholarly journals Spinal Hemangioblastomas: Analysis of Surgical Outcome and Prognostic Factors

2021 ◽  
Author(s):  
Alberto Feletti ◽  
Alessandro Boaro ◽  
Davide Giampiccolo ◽  
Giorgio Casoli ◽  
Fabio Moscolo ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Neurological Outcome ◽  
Statistical Significance ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Neurological Condition ◽  
Before And After ◽  
Vhl Disease ◽  
The Impact

Abstract Background. The prognostic factors for surgically removed spinal hemangioblastomas, the impact of VHL disease on outcome, and the role of intraoperative neuromonitoring are still not completely clear. The aim of this study was to review our experience with spinal hemangioblastomas in order to assess potential predictors of neurological outcome after surgery.Methods. All cases of spinal hemangioblastomas removed at two Italian academic institutions from 1985 to 2020 were reviewed. Data about clinical presentation and symptoms duration, diagnosis of VHL, surgical approach, use of IONM, duration of hospital stay, follow up, McCormick grade before and after surgery were extracted.Results. Sixty-one patients (31 F, 30 M) underwent 69 surgeries to remove 74 spinal hemangioblastomas (37 cervical, 32 thoracic, 5 lumbar). Improvement was found in 32.3% of cases, neurological condition remained stable in 51.6% of cases, and deteriorated in 16.1% of patients.A worsening trend in VHL patients and an improvement trend in non-VHL patients were detected, despite the lack of statistical significance. Laminotomy and use of IONM were found to be associated with better outcome, although no association was found between surgery without IOM and worse outcome.Conclusion. In most cases, patients affected by spinal hemangioblastomas can expect a good long-term outcome. In our experience, laminotomy seems to be associated with better outcome compared to laminectomy. While its absence is not associated with worse outcome, IONM seems to be associated with a better neurological outcome. Our study suggests that the more impaired the preoperative neurological condition, the worse the outcome.

scholarly journals Partial Biliary Diversion May Promote Long-Term Relief of Pruritus and Native Liver Survival in Children with Cholestatic Liver Diseases

2020 ◽  
Author(s):  
Kristin Bjørnland ◽  
Maria Hukkinen ◽  
Vladimir Gatzinsky ◽  
Henrik Arnell ◽  
Mikko P. Pakarinen ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Diseases ◽  
Serum Levels ◽  
Cholestatic Liver Disease ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Biliary Diversion ◽  
Native Liver ◽  
Native Liver Survival

Abstract Introduction Rare cholestatic liver diseases may cause debilitating pruritus in children. Partial biliary diversion (PBD) may relieve pruritus and postpone liver transplantation which is the only other alternative when conservative treatment fails. The aim was to report long-term outcome after PBD in a population of 26 million people during a 25-year period. Materials and Methods This is an international, multicenter retrospective study reviewing medical journals. Complications were graded according to the Clavien–Dindo classification system. Results Thirty-three patients, 14 males, underwent PBD at a median of 1.5 (0.3–13) years at four Nordic pediatric surgical centers. Progressive familial intrahepatic cholestasis was the most common underlying condition. Initially, all patients got external diversion, either cholecystojejunostomy (25 patients) or button placed in the gallbladder or a jejunal conduit. Early complications occurred in 14 (42%) patients, of which 3 were Clavien–Dindo grade 3. Long-term stoma-related complications were common (55%). Twenty secondary surgeries were performed due to stoma problems such as prolapse, stricture, and bleeding, or conversion to another form of PBD. Thirteen children have undergone liver transplantation, and two are listed for transplantation due to inefficient effect of PBD on pruritus. Serum levels of bile acids in the first week after PBD construction were significantly lower in patients with good relief of pruritus than in those with poor effect (13 [2–192] vs. 148 [5–383] μmol/L; p = 0.02). Conclusion PBD may ensure long-term satisfactory effect on intolerable pruritus and native liver survival in children with cholestatic liver disease. However, stoma-related problems and reoperations are common.

The Long-Term Outcome of Depressive Illness

1988 ◽  
Vol 153 (6) ◽  
pp. 752-757 ◽  
Author(s):  
L. G. Kiloh ◽  
Gavin Andrews ◽  
Megan Neilson
Keyword(s):  
Endogenous Depression ◽  
Depressive Illness ◽  
Index Admission ◽  
University Hospital ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Considerable Morbidity ◽  
Adequate Data

One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained continuously well. Patients for whom the index admission was not their first were especially likely to be readmitted during the follow-up period. Patients with endogenous depression, none of whom developed schizophrenia during the follow-up period, were more likely to need readmission than patients with an index diagnosis of neurotic depression. In all other respects the prognosis for the two types of depression was the same, with considerable morbidity evident in both.

scholarly journals Influence of early adalimumab serum levels on immunogenicity and long-term outcome of anti-TNF naive Crohn's disease patients: the usefulness of rapid testing

2018 ◽  
Vol 48 (7) ◽  
pp. 731-739 ◽  
Author(s):  
Bram Verstockt ◽  
Gitte Moors ◽  
Sumin Bian ◽  
Thomas Van Stappen ◽  
Gert Van Assche ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Serum Levels ◽  
Rapid Testing ◽  
Term Outcome ◽  
Long Term Outcome
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