THE EFFECT OF PITUITARY-ADRENAL MANIPULATIONS UPON URINARY CYCLIC AMP EXCRETION IN MAN

1977 ◽  
Vol 84 (2) ◽  
pp. 343-348 ◽  
Author(s):  
Robert Perlstein ◽  
Lowell Kopp ◽  
Joseph R. Tucci
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Adrenal Axis ◽  
Urinary Cyclic Amp ◽  
Pituitary Adrenal Axis

ABSTRACT The present studies demonstrate that the administration of pharmacologic amounts of ACTH is associated with small but significant increases in urinary cyclic AMP excretion and in urinary cyclic AMP/creatinine ratios which are most likely related to a release of cyclic AMP from adrenocortical tissue. Acute suppression of the pituitary-adrenal axis with dexamethasone and stimulation with metyrapone, however, is not associated with changes in urinary cyclic AMP excretion. These results suggest that physiological levels of ACTH and cortisol contribute little, if any, to the urinary excretion of cyclic AMP in man.

Effects of semistarvation and water deprivation on adrenal cortical function and corticosteroid metabolism

1959 ◽  
Vol 14 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Robert A. Huseby ◽  
Fredrick C. Reed ◽  
Thomas E. Smith
Keyword(s):  
Urinary Excretion ◽  
Water Deprivation ◽  
Control Period ◽  
Adrenal Steroids ◽  
Protein Deprivation ◽  
Cortical Function ◽  
Adrenal Axis ◽  
Young Subjects ◽  
Pituitary Adrenal Axis ◽  
Adrenal Cortical Function

The urinary excretion of 17-KS and 17-OH-CS and the level of circulating unconjugated 17-OH-CS in the plasma were determined in 12 healthy young subjects during a 16-day period of acute undernutrition. In half the group, the intake of water was also significantly restricted during the first 5 1/2 days. The data indicate that although the urinary excretion of steroid metabolites decreased rapidly during the first 6 days of undernutrition and then stabilized at a level approximately half that seen in the control period, the level of circulating unconjugated 17-OH-CS in the plasma was not depressed by this degree of acute undernutrition and protein deprivation. Dehydration increased the level of circulating unconjugated 17-OH-CS, indicating that the pituitary-adrenal axis could respond to ‘stress’ when the diet was calorically inadequate and protein-deficient. These findings have been interpreted as indicating that acute undernutrition and protein deprivation alter the catabolism of adrenal steroids, but that the level of circulating hormonally-active corticosteroids reaching the tissues of the organism is probably adequate. Submitted on July 28, 1958

THE EFFECT OF TREATMENT OF HYPERAND HYPOTHYROIDISM ON URINARY EXCRETION OF CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE

1977 ◽  
Vol 84 (3) ◽  
pp. 542-547 ◽  
Author(s):  
D. J. Carter ◽  
D. A. Heath
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Thyroid Disease ◽  
Primary Hypothyroidism ◽  
Euthyroid Status ◽  
Urinary Cyclic Amp ◽  
Effect Of Treatment ◽  
Significant Change ◽  
Hyperthyroid Patients

ABSTRACT The urinary excretion of cyclic adenosine 3′,5′-monophosphate (cyclic AMP) was examined in patients with hyperthyroidism and primary hypothyroidism, before treatment and at least six months later on return to euthyroid status. Urinary cyclic AMP excretion was significantly greater in the hyperthyroid group than in the hypothyroid group both in the basal state (P < 0.01) and the ambulant state (P < 0.001). In ambulant hyperthyroid patients absolute urinary cyclic AMP excretion (μmol/24 h) was significantly greater (P < 0.05) prior to treatment than on return to euthyroid status. In the hypothyroid group no significant change occurred after treatment with 1-thyroxine (P > 0.05). The mechanism of changes in urinary cyclic AMP excretion in thyroid disease are discussed.

Urinary Cyclic AMP in the Switch Process from Depression to Mania

1974 ◽  
Vol 125 (588) ◽  
pp. 457-458 ◽  
Author(s):  
R. P. Hullin ◽  
J. G. Salway ◽  
M. N. E. Allsopp ◽  
Janet D. M. Albano ◽  
G. Dawn Barnes ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Bipolar Patient ◽  
Transient Increase ◽  
Short Cycle ◽  
General Lack ◽  
Mood Changes ◽  
Manic Depressive ◽  
Urinary Cyclic Amp ◽  
Depressive Patients

Various reports have suggested that the urinary excretion of adenosine cyclic 3'5’ monophosphate (cyclic AMP) is increased in mania and decreased in depression. However, our own serial studies from short-cycle bipolar manic-depressive patients showed no correlation between mood and cyclic AMP excretion (2). Jenner et al. (4) confirmed our findings, except in the case of a patient with a regular 48-hour mood cycle who did show a correlation between his mood changes and changes in cyclic AMP excretion. Paul et al. (5) also reported a general lack of correlation between these variables, but found a transient increase of urinary cyclic AMP during the rapid switch from depression to mania. We have investigated the situation in a bipolar patient who shows such a rapid switch in mood but have been unable to demonstrate any increase in cyclic AMP excretion during the switch period.

Urinary Excretion of Adenosine 3’: 5′-Cyclic Monophosphate in Depressive Illness

1974 ◽  
Vol 125 (586) ◽  
pp. 275-279 ◽  
Author(s):  
Graham J. Naylor ◽  
David A. Stansfield ◽  
Susan F. Whyte ◽  
Frederick Hutchinson
Keyword(s):  
Cyclic Amp ◽  
Urinary Excretion ◽  
Affective State ◽  
Depressive Illness ◽  
Control Group ◽  
Cyclic Monophosphate ◽  
Manic Depressive ◽  
Two Samples ◽  
Urinary Cyclic Amp ◽  
Depressive Patients

Changes in the excretion of adenosine 3’:5′-cyclic monophosphate (cyclic AMP) have been reported in depressive illness. Abdulla and Hamadah (1970) reported that urinary cyclic AMP excretion was lower than normal during depression and increased with recovery. However, these results were based on single 24-hour urine collections during depression and on recovery, with no creatinine estimations to suggest that the collections were complete. There was no control of diet, drugs or activity. The controls do not appear to have been matched for age. Paul, Ditzion, Pauk and Janowsky (1970) reported that the cyclic AMP excretion in neurotic depression was higher and in psychotic depression was lower than in a control group, but neither difference was statistically significant. However, on enlarging the study by including more psychotic depressives they reported that the cyclic AMP excretion of this group was significantly less than that of the controls (Paul, Cramer and Goodwin, 1971). These workers had controlled the patients' drug and dietary (but not fluid) intake. There appeared to be only minimal control of activity. The results were based on approximately two samples of urine per subject, which were very carefully checked for completeness of collection. Unfortunately the age of the controls (19–22 years) was very different from that of the patients (25–64 years). On two small groups of patients treated with either Laevodopa or lithium carbonate, they reported that changes in affective state were accompanied by changes in the urinary excretion of cyclic AMP. However, in serial studies on manic-depressive patients Paul, Cramer and Bunney (1971) failed to show a correlation between mood rating and cyclic AMP excretion in five out of seven patients; but they reported that the cyclic AMP excretion was increased on the day of rapid switch from depression to mania. The above groups of workers had used an enzymatic-isotope displacement technique to estimate the cyclic AMP. Brown, Salway, Albano, Hullin and Ekins (1972), using a saturation method to assay cyclic AMP, found no correlation between mood and cyclic AMP excretion in two short-cycle manic-depressive patients. Jenner, Sampson, Thompson, Somerville, Beard and Smith (1972) wrote: ‘We have measured daily excretion by a number of depressed and manic depressive patients over periods covering several mood changes without being able to establish any consistent correlation between cyclic AMP excretion and mood, … However, in one unusual case we have found a very marked correlation‘. We (Naylor, Dick, Dick, Moody and Stansfield, 1974) were unable to demonstrate any relationship between urinary cyclic AMP excretion and mood in a patient with recurrent psychotic episodes, in which depressive features predominated.

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