Vitamin a and its Transport Proteins in Patients with Chronic Renal Failure Receiving Maintenance Haemodialysis and after Renal Transplantation

1983 ◽  
Vol 65 (6) ◽  
pp. 619-626 ◽  
Author(s):  
J. Kelleher ◽  
C. S. Humphrey ◽  
Dana Homer ◽  
A. M. Davison ◽  
G. R. Giles ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Vitamin A ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Retinol Binding Protein ◽  
Maintenance Haemodialysis ◽  
Protein Levels ◽  
Normal Individuals

1. Serum vitamin A, retinol binding protein, prealbumin and transferrin have been studied in chronic renal failure patients receiving maintenance haemodialysis and after renal transplantation. 2. Vitamin A and retinol binding protein were uniformly raised in haemodialysis patients and this was unrelated to the period on dialysis. There was a molar excess of retinol binding protein to both vitamin A and prealbumin as compared with normal individuals. 3. Renal transplantation significantly reduces serum vitamin A and retinol binding protein concentrations but has no effect on prealbumin concentrations. The reduction in vitamin A and retinol binding protein is variable in individual patients and cannot be predicted either by the allograft function or time since transplantation. 4. Several years after transplantation, with normal serum creatinine, both serum vitamin A and retinol binding protein levels may still be greatly increased. Despite the very high vitamin A and retinol binding protein concentrations, the close correlation between the two seen in normal individuals is well maintained. 5. The continuing high vitamin A and retinol binding protein levels in patients with satisfactorily functioning transplants is unexplained.

Use of free and transthyretin-bound retinol-binding protein in serum as tests of vitamin A status in humans: effect of high creatinine concentrations in serum

1990 ◽  
Vol 36 (4) ◽  
pp. 674-676 ◽  
Author(s):  
B J Burri ◽  
D D Bankson ◽  
T R Neidlinger
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Vitamin A ◽  
Serum Creatinine ◽  
Binding Protein ◽  
High Serum ◽  
Retinol Binding Protein ◽  
Creatinine Concentration ◽  
Vitamin A Status ◽  
Chromatographic Peaks

Abstract We measured immunologically active (apo + holo) retinol-binding protein (RBP), vitamin A-carrying (holo) free RBP, and transthyretin-bound (TTR) holo-RBP in serum from 34 retrospective cases of fluctuating acute renal failure. All subjects had high serum creatinine concentrations caused by renal failure. Apo + holo, holo-TTR-RBP, and (especially) holo-free RBP all correlated poorly but significantly with serum creatinine concentration. Therefore, the use of any form of RBP to measure vitamin A status may be of limited value in subjects with high creatinine concentrations in serum. However, molecular-exclusion HPLC may be able to distinguish increases in RBP concentration associated with renal failure from those caused by altered vitamin A status, because renal failure causes abnormalities in the number and retention times of chromatographic peaks as well as their areas.

Serum vitamin A, retinol-binding protein, and prealbumin concentrations in protein-calorie malnutrition

1973 ◽  
Vol 26 (9) ◽  
pp. 982-987 ◽  
Author(s):  
Frank Rees Smith ◽  
DeWitt S. Goodman ◽  
Guillermo Arroyave ◽  
Fernando Viteri
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Serum Vitamin ◽  
Retinol Binding Protein ◽  
Protein Calorie Malnutrition

Analysis of normal and truncated holo- and apo-retinol-binding protein (RBP) in human serum: altered ratios in chronic renal failure

1996 ◽  
Vol 134 (5) ◽  
pp. 576-582 ◽  
Author(s):  
Stefano Jaconi ◽  
Jean-Hilaire Saurat ◽  
Georges Siegenthaler
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Human Serum ◽  
Binding Protein ◽  
Normal Serum ◽  
Retinol Binding Protein ◽  
Hypervitaminosis A ◽  
Analytical Strategy ◽  
Almost All

Jaconi S, Saurat J-H, Siegenthaler G. Analysis of normal and truncated holo- and apo-retinol-binding protein (RBP) in human serum: altered ratios in chronic renal failure. Eur J Endocrinol 1996;134:576–82. ISSN 0804–4643 Retinol, the precursor of the retinoic acid hormone, is transported in the serum by a specific carrier, the retinol-binding protein (RBP). Compared to serum of healthy controls, the serum of patients with chronic renal failure (CRF) contains markedly increased levels of the RBP form truncated at the C-terminal, des(182Leu-183Leu). (RBP2). which suggests that RBP2 is cleared by the kidney in healthy people but accumulates in serum of CRF patients (Jaconi S, et al. J Lipid Res 1995;36:1247–53). To understand better the mechanism of retinol transport, we have developed a new analytical strategy to analyze the various forms of RBP that circulate in the blood: RBP with and without retinol (holo- and apo-RBP, respectively), RBP bound or not to transthyretin (TTR) and to determine in which of these forms RBP2 circulates. We confirm, but now by direct measurement, that holo-RBP and, to a larger extent, apo-RBP are increased in CRF serum compared to normal serum. We also show that almost all apo-RBP and about 50% of total holo-RBP, corresponding to RBP excess in CRF serum, circulate free and are not complexed to TTR, the remaining 50% being complexed to TTR. This observation suggests that the high levels of free holo-RBP, not bound to TTR, which correspond to the increase in total RBPs measured in CRF serum, may alter the tissue uptake of retinol and be responsible for the signs of hypervitaminosis A observed in these patients. Secondly, we found that the truncation resulting in RBP2 does not alter its binding properties for retinol nor those of holo-RBP2 for TTR. We observed that the high amounts of free holo-RBP2 and holo-RBP in sera of CRF patients were low in normal serum, suggesting that these forms are cleared by the kidney in normal conditions. The possible role of free holo-RBPs is discussed in the context of retinol recycling. Georges Siegenthaler, Clinique de Dermatologie, Hôpital Cantonal Universitaire, CH-1211 Geneve 14, Switzerland

The effect of vitamin A supplementation on serum retinol and retinol binding protein levels

1985 ◽  
Vol 29 (2) ◽  
pp. 203-213 ◽  
Author(s):  
N.J. Wald ◽  
H.S. Cuckle ◽  
R.D. Barlow ◽  
P. Thompson ◽  
K. Nanchahal ◽  
...  
Keyword(s):  
Vitamin A ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Serum Retinol ◽  
Vitamin A Supplementation ◽  
Protein Levels

Intestinal fatty acid–binding protein levels in patients with chronic renal failure

2018 ◽  
Vol 230 ◽  
pp. 94-100 ◽  
Author(s):  
Kyoko Okada ◽  
Motohiro Sekino ◽  
Hiroyuki Funaoka ◽  
Shuntaro Sato ◽  
Taiga Ichinomiya ◽  
...  
Keyword(s):  
Renal Failure ◽  
Fatty Acid ◽  
Chronic Renal Failure ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Protein Levels ◽  
Acid Binding Protein
Sign in / Sign up

Export Citation Format

Share Document