DIFFERENTIAL EFFECTS OF CASTRATION ON LH AND FSH SECRETION IN MALE AND FEMALE RATS

1975 ◽  
Vol 78 (4) ◽  
pp. 683-688 ◽  
Author(s):  
M. Zanisi ◽  
L. Martini
Keyword(s):  
Serum Levels ◽  
Female Rats ◽  
Delayed Response ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats ◽  
Normal Controls

ABSTRACT Serum levels of LH and of FSH have been measured using specific radioimmunological procedures in normal controls and in male and female rats submitted to castration 1, 2, 7, 14, 21, 28 and 35 days before. Gonadectomy is followed by a rapid increase of serum levels of LH in males, and by a delayed response in females. The responses of serum FSH to castration are quantitatively and qualitatively similar in the two sexes. Both in males and in females an elevation of serum FSH levels is already present 1 day after the operation. Serum FSH continues to rise, between post-castration days 1 and 7 with a rather rapid slope, and at later intervals with a smoother progression.

Differential effects of gonadal function on bone histomorphometry in male and female rats

2009 ◽  
Vol 4 (4) ◽  
pp. 557-563 ◽  
Author(s):  
Russell T. Turner ◽  
Kathleen S. Hannon ◽  
Laurence M. Demers ◽  
James Buchanan ◽  
Norman H. Bell
Keyword(s):  
Bone Histomorphometry ◽  
Female Rats ◽  
Gonadal Function ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

scholarly journals Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mohammad-Sedigh Khosravi ◽  
Alireza Samimiat ◽  
Bahar Mazaheri ◽  
Farzaneh Ashrafi ◽  
Ardeshir Talebi ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Kidney Tissue ◽  
Serum Levels ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Female Wistar Rats ◽  
Solid Tumor Therapy ◽  
Cisplatin Therapy

Backgrounds. Cisplatin (CP) still is a novel choice for solid tumor therapy, but it is accompanied with the side effect of nephrotoxicity. Hydration may reduce the risk of CP-induced nephrotoxicity, while the issue is still challenging. In this study, five types of hydration protocols including saline, mannitol, dextrose saline, saline plus furosemide, and saline plus mannitol were examined in both sexes of rats during CP therapy. Methods. Seventy-six male and female Wistar rats in 14 groups of experiments were subjected to CP therapy, and five types of hydration protocols were implemented, and the induced nephrotoxicity was evaluated via biochemical markers, kidney function parameters, and pathology investigation. Results. Male and female rats had different responses to hydration protocol types. The higher mortality rate was seen in female rats that received mannitol or dextrose hydration types. In addition, the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and sodium excretion fraction (ENa%) increased and the clearance of Cr (ClCr) decreased significantly ( P < 0.05 ) in female rats hydrated with saline plus furosemide or mannitol plus saline-treated groups. The worsened condition in male rats is observed in the mannitol hydration group with a significant decrease of ClCr and significant increase of serum BUN and Cr and ENa% ( P < 0.05 ). The higher kidney tissue damage score (KTDS) in the mentioned groups verified the findings. Conclusion. Hydration with mannitol or dextrose promotes the risk of nephrotoxicity during CP therapy with more intensity on the female.

Differential effects of gonadectomy on the thymocyte phenotypic profile in male and female rats

1996 ◽  
Vol 54 (1) ◽  
pp. 269-276 ◽  
Author(s):  
G. Leposavić ◽  
B. Karapetrović ◽  
S. Obradović ◽  
B.Vidić Danković ◽  
D. Kosec
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Phenotypic Profile ◽  
Male And Female Rats

Differential effects of handling on exploration in male and female rats

1978 ◽  
Vol 11 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Joanne Weinberg ◽  
Emily A. Krahn ◽  
Seymour Levine
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

scholarly journals Social context has differential effects on acquisition of nicotine self-administration in male and female rats

2017 ◽  
Vol 234 (12) ◽  
pp. 1815-1828 ◽  
Author(s):  
Natalie A. Peartree ◽  
Kayla N. Hatch ◽  
Julianna G. Goenaga ◽  
Nora R. Dado ◽  
Hanna Molla ◽  
...  
Keyword(s):  
Social Context ◽  
Female Rats ◽  
Self Administration ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

Peripheral and Central Sex Steroids Have Differential Effects on the HPA Axis of Male and Female Rats

Stress ◽  
2002 ◽  
Vol 5 (4) ◽  
pp. 235-247 ◽  
Author(s):  
Cheryl M. McCormick ◽  
William Linkroum ◽  
Bethany J. Sallinen ◽  
Nicholas W. Miller
Keyword(s):  
Hpa Axis ◽  
Sex Steroids ◽  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

scholarly journals Cyclosporine-A induced nephrotoxicity in male and female rats: Is zinc a suitable protective supplement?

2018 ◽  
Vol 5 (12) ◽  
pp. 2888-2897
Author(s):  
Samira Choopani ◽  
Sayyedehnikta Kasaei ◽  
Ardeshir Talebi ◽  
Mojgan Mortazavi ◽  
Yousef Gheisari ◽  
...  
Keyword(s):  
Kidney Tissue ◽  
Serum Levels ◽  
Female Rats ◽  
Histological Evaluation ◽  
High Dose ◽  
Kidney Transplant Patient ◽  
Male And Female ◽  
Male And Female Rats ◽  
Tissue Damages

Background: Cyclosporine (CYC) is an immunosuppressant drug used widely in kidney transplant patient. The major side effect of CYC is nephrotoxicity. In this study, three different doses of CYC alone or accompanied with zinc (Zn) supplement were administrated in male and female rats to determine the kidney tissue damages and functions. Methods: Male and female rats were treated with 10, 50 or 100 mg/kg/day of CYC alone or accompanied with 10 mg /kg/day of Zn sulfate for 10 days. The parameters related to renal function were determined and the kidney tissues were subjected to histological evaluation. Results: All male and female animals were treated with high dose CYC (100 mg/kg/day) alone or accompanied with Zn supplement during the experiment. The data obtained for the serum levels of creatinine (Cr) and blood urea nitrogen/Cr ratio, clearance of Cr, kidney weight (KW), sodium (Na) filtration rate, Na excretion rate and Na excretion fraction (%) in surviving animals suggest a role of gender in the variation of these factors. The kidney tissue damage score (KTDS) was increased as the dosage of CYC was elevated, and the Zn supplement attenuated the KTDS in animals treated with low dose CYC (10 mg/kg/day). Conclusion: The CYC-induced nephrotoxicity may be gender-related, and the 10 mg/kg dose of Zn sulphate as a supplement may possibly prevent the induced nephrotoxicity in males due to its antioxidant effects.  

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