scholarly journals Differential Effects of Prenatal and Postnatal Nutritional Environment on β-Cell Mass Development and Turnover in Male and Female Rats

2010 ◽  
Vol 95 (12) ◽  
pp. 5454-5454
Author(s):  
Aleksey V. Matveyenko ◽  
Inderroop Singh ◽  
Bo-Chul Shin ◽  
Senta Georgia ◽  
Sherin U. Devaskar
Keyword(s):  
Cell Mass ◽  
Female Rats ◽  
Β Cell ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats ◽  
Nutritional Environment ◽  
Mass Development

scholarly journals Differential Effects of Prenatal and Postnatal Nutritional Environment on β-Cell Mass Development and Turnover in Male and Female Rats

2010 ◽  
Vol 31 (6) ◽  
pp. 940-940
Author(s):  
Aleksey V. Matveyenko ◽  
Inderroop Singh ◽  
Bo-Chul Shin ◽  
Senta Georgia ◽  
Sherin U. Devaskar
Keyword(s):  
Cell Mass ◽  
Female Rats ◽  
Β Cell ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats ◽  
Nutritional Environment ◽  
Mass Development

scholarly journals Differential Effects of Prenatal and Postnatal Nutritional Environment on β-Cell Mass Development and Turnover in Male and Female Rats

Endocrinology ◽  
2010 ◽  
Vol 151 (12) ◽  
pp. 5647-5656 ◽  
Author(s):  
Aleksey V. Matveyenko ◽  
Inderroop Singh ◽  
Bo-Chul Shin ◽  
Senta Georgia ◽  
Sherin U. Devaskar
Keyword(s):  
Type 2 Diabetes ◽  
Cell Mass ◽  
Growth Restriction ◽  
Female Rats ◽  
Cell Replication ◽  
Β Cell ◽  
Male And Female ◽  
Fractional Area ◽  
Mass Development

Fetal nutrient and growth restriction is associated with development of type 2 diabetes. Although the exact mechanisms responsible for this association remain debated, intrauterine and/or postnatal maldevelopment of β-cell mass has been proposed as a potential mechanism. To address this hypothesis, β-cell mass development and turnover was assessed in rats exposed to either intrauterine and/or postnatal caloric/growth restriction. In total, four groups of male and female Sprague Dawley rats (n = 69) were developed and studied: 1) control rats, i.e. control mothers rearing control pups; 2) intrauterine calorically and growth-restricted rats, i.e. 50% prenatal calorically restricted pups cross-fostered to control mothers; 3) postnatal calorically and growth-restricted rats, i.e. 50% calorically restricted mothers rearing pups born to control mothers; and 4) prenatal and postnatal calorically and growth restricted rats, i.e. 50% calorically restricted mothers rearing intrauterine 50% calorically restricted pups. Intrauterine growth restriction resulted in approximately 45% reduction of postnatal β-cell fractional area and mass characterized by reduced rate of β-cell replication and decreased evidence of neogenesis. In contrast, β-cell fractional area and weight-adjusted β-cell mass in postnatal growth restriction was approximately 30% higher than in control rats. Rats exposed to both intrauterine and postnatal caloric and growth restriction demonstrated approximately 80% decrease in β-cell mass, reduction in β-cell replication, and decreased evidence of neogenesis compared with control. Neither intrauterine nor postnatal caloric restriction significantly affected the rate of β-cell apoptosis. These data support the hypothesis that intrauterine maldevelopment of β-cell mass may predict the increased risk of type 2 diabetes in adult life.

Differential effects of gonadal function on bone histomorphometry in male and female rats

2009 ◽  
Vol 4 (4) ◽  
pp. 557-563 ◽  
Author(s):  
Russell T. Turner ◽  
Kathleen S. Hannon ◽  
Laurence M. Demers ◽  
James Buchanan ◽  
Norman H. Bell
Keyword(s):  
Bone Histomorphometry ◽  
Female Rats ◽  
Gonadal Function ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

DIFFERENTIAL EFFECTS OF CASTRATION ON LH AND FSH SECRETION IN MALE AND FEMALE RATS

1975 ◽  
Vol 78 (4) ◽  
pp. 683-688 ◽  
Author(s):  
M. Zanisi ◽  
L. Martini
Keyword(s):  
Serum Levels ◽  
Female Rats ◽  
Delayed Response ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats ◽  
Normal Controls

ABSTRACT Serum levels of LH and of FSH have been measured using specific radioimmunological procedures in normal controls and in male and female rats submitted to castration 1, 2, 7, 14, 21, 28 and 35 days before. Gonadectomy is followed by a rapid increase of serum levels of LH in males, and by a delayed response in females. The responses of serum FSH to castration are quantitatively and qualitatively similar in the two sexes. Both in males and in females an elevation of serum FSH levels is already present 1 day after the operation. Serum FSH continues to rise, between post-castration days 1 and 7 with a rather rapid slope, and at later intervals with a smoother progression.

Differential effects of gonadectomy on the thymocyte phenotypic profile in male and female rats

1996 ◽  
Vol 54 (1) ◽  
pp. 269-276 ◽  
Author(s):  
G. Leposavić ◽  
B. Karapetrović ◽  
S. Obradović ◽  
B.Vidić Danković ◽  
D. Kosec
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Phenotypic Profile ◽  
Male And Female Rats

Differential effects of handling on exploration in male and female rats

1978 ◽  
Vol 11 (3) ◽  
pp. 251-259 ◽  
Author(s):  
Joanne Weinberg ◽  
Emily A. Krahn ◽  
Seymour Levine
Keyword(s):  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

scholarly journals Social context has differential effects on acquisition of nicotine self-administration in male and female rats

2017 ◽  
Vol 234 (12) ◽  
pp. 1815-1828 ◽  
Author(s):  
Natalie A. Peartree ◽  
Kayla N. Hatch ◽  
Julianna G. Goenaga ◽  
Nora R. Dado ◽  
Hanna Molla ◽  
...  
Keyword(s):  
Social Context ◽  
Female Rats ◽  
Self Administration ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats

Peripheral and Central Sex Steroids Have Differential Effects on the HPA Axis of Male and Female Rats

Stress ◽  
2002 ◽  
Vol 5 (4) ◽  
pp. 235-247 ◽  
Author(s):  
Cheryl M. McCormick ◽  
William Linkroum ◽  
Bethany J. Sallinen ◽  
Nicholas W. Miller
Keyword(s):  
Hpa Axis ◽  
Sex Steroids ◽  
Female Rats ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats
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