Effects of Morphine and Naloxone on Serum Levels of Luteinizing Hormone and Prolactin in Prepubertal Male and Female Rats

1979 ◽  
Vol 29 (4) ◽  
pp. 288-292 ◽  
Author(s):  
T. Ieiri ◽  
H.T. Chen ◽  
J. Meites
Keyword(s):  
Luteinizing Hormone ◽  
Serum Levels ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Hydration with Mannitol and Dextrose May Promote Cisplatin-Induced Nephrotoxicity: Test of Five Protocols of Hydration during Cisplatin Therapy in Rat Models

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Mohammad-Sedigh Khosravi ◽  
Alireza Samimiat ◽  
Bahar Mazaheri ◽  
Farzaneh Ashrafi ◽  
Ardeshir Talebi ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Kidney Tissue ◽  
Serum Levels ◽  
Female Rats ◽  
Male Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Female Wistar Rats ◽  
Solid Tumor Therapy ◽  
Cisplatin Therapy

Backgrounds. Cisplatin (CP) still is a novel choice for solid tumor therapy, but it is accompanied with the side effect of nephrotoxicity. Hydration may reduce the risk of CP-induced nephrotoxicity, while the issue is still challenging. In this study, five types of hydration protocols including saline, mannitol, dextrose saline, saline plus furosemide, and saline plus mannitol were examined in both sexes of rats during CP therapy. Methods. Seventy-six male and female Wistar rats in 14 groups of experiments were subjected to CP therapy, and five types of hydration protocols were implemented, and the induced nephrotoxicity was evaluated via biochemical markers, kidney function parameters, and pathology investigation. Results. Male and female rats had different responses to hydration protocol types. The higher mortality rate was seen in female rats that received mannitol or dextrose hydration types. In addition, the serum levels of blood urea nitrogen (BUN) and creatinine (Cr) and sodium excretion fraction (ENa%) increased and the clearance of Cr (ClCr) decreased significantly ( P < 0.05 ) in female rats hydrated with saline plus furosemide or mannitol plus saline-treated groups. The worsened condition in male rats is observed in the mannitol hydration group with a significant decrease of ClCr and significant increase of serum BUN and Cr and ENa% ( P < 0.05 ). The higher kidney tissue damage score (KTDS) in the mentioned groups verified the findings. Conclusion. Hydration with mannitol or dextrose promotes the risk of nephrotoxicity during CP therapy with more intensity on the female.

DIFFERENTIAL EFFECTS OF CASTRATION ON LH AND FSH SECRETION IN MALE AND FEMALE RATS

1975 ◽  
Vol 78 (4) ◽  
pp. 683-688 ◽  
Author(s):  
M. Zanisi ◽  
L. Martini
Keyword(s):  
Serum Levels ◽  
Female Rats ◽  
Delayed Response ◽  
Male And Female ◽  
Differential Effects ◽  
Male And Female Rats ◽  
Normal Controls

ABSTRACT Serum levels of LH and of FSH have been measured using specific radioimmunological procedures in normal controls and in male and female rats submitted to castration 1, 2, 7, 14, 21, 28 and 35 days before. Gonadectomy is followed by a rapid increase of serum levels of LH in males, and by a delayed response in females. The responses of serum FSH to castration are quantitatively and qualitatively similar in the two sexes. Both in males and in females an elevation of serum FSH levels is already present 1 day after the operation. Serum FSH continues to rise, between post-castration days 1 and 7 with a rather rapid slope, and at later intervals with a smoother progression.

Regulation of luteinizing hormone secretion in prepubertal male and female rats

Life Sciences ◽  
1982 ◽  
Vol 31 (20-21) ◽  
pp. 2167-2170 ◽  
Author(s):  
Rüdiger Schulz ◽  
Annemarie Wilhelm ◽  
Karl Martin Pirke ◽  
Albert Herz
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Secretion ◽  
Female Rats ◽  
Luteinizing Hormone Secretion ◽  
Male And Female ◽  
Male And Female Rats

Effect of Purified Luteinizing Hormone-Releasing Factor on Plasma and Pituitary LH Levels in Castrated, Testosterone Pretreated Male and Female Rats

Endocrinology ◽  
1967 ◽  
Vol 81 (5) ◽  
pp. 1173-1176 ◽  
Author(s):  
ANDREW V. SCHALLY ◽  
WELDON H. CARTER ◽  
AKIRA ARIMURA ◽  
CYRIL Y. BOWERS
Keyword(s):  
Luteinizing Hormone ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats
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