scholarly journals Fabrication of triblock ABA type peptide dendrimer based on glutamic acid dimethyl ester and PEG as a potential nano drug delivery agent

Bioimpacts ◽  
2017 ◽  
Vol 4 (4) ◽  
pp. 175-182 ◽  
Author(s):  
Hassan Namazi ◽  
Yousef Toomari ◽  
Hassan Abbaspour
Keyword(s):  
Drug Delivery ◽  
Glutamic Acid ◽  
Dimethyl Ester ◽  
Acid Dimethyl Ester ◽  
Nano Drug Delivery ◽  
Peptide Dendrimer

Insulinotropic action of glutamic acid dimethyl ester

1994 ◽  
Vol 267 (4) ◽  
pp. E573-E584 ◽  
Author(s):  
A. Sener ◽  
I. Conget ◽  
J. Rasschaert ◽  
V. Leclercq-Meyer ◽  
M. L. Villanueva-Penacarrillo ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Insulin Release ◽  
Dimethyl Ester ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
O2 Uptake ◽  
Acid Dimethyl Ester ◽  
Insulin Dependent ◽  
Early Fall ◽  
Stimulate Insulin Release

Glutamic acid dimethyl ester (GME; 3.0–10.0 mM) enhanced insulin release evoked by 6.0–8.3 mM D-glucose, 1.0–10.0 mM L-leucine, or 5.0–10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, causing a shift to the left of the sigmoidal relationship between insulin output and D-glucose concentration. In the absence of D-glucose, GME also unmasked the insulinotropic potential of glibenclamide. In islets exposed to L-leucine, the insulinotropic action of GME coincided with an early fall and later increase in 86Rb outflow and augmentation of 45Ca outflow from prelabeled islets. The measurement of O2 uptake, NH4+ output, production of 14CO2 from islets prelabeled with [U-14C]palmitate, generation of 14C-labeled amino acids and 14CO2 from the dimethyl ester of either L-[1-14C]glutamic acid or L-[U-14C]glutamic acid, and D-[2-14C]glucose as well as D-[6-14C]glucose oxidation in the presence or absence of GME indicated that the latter ester was efficiently converted to L-glutamate and its further metabolites. The overall gain in O2 uptake represented the balance between GME oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous D-glucose. It is proposed that GME might represent a new tool to bypass beta-cell defects in D-glucose transport, phosphorylation, and further metabolism and, hence, to stimulate insulin release in experiments conducted in animal models of non-insulin-dependent diabetes mellitus.

Recent Advances of Mesoporous Silica Based Multifunctional Nano Drug Delivery Systems

2013 ◽  
Vol 40 (10) ◽  
pp. 1014
Author(s):  
Xiao-Hong HAO ◽  
Cui-Miao ZHANG ◽  
Xiao-Long LIU ◽  
Xing-Jie LIANG ◽  
Guang JIA ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

2018 ◽  
Vol 18 (10) ◽  
pp. 857-880 ◽  
Author(s):  
Salma E. Ahmed ◽  
Nahid Awad ◽  
Vinod Paul ◽  
Hesham G. Moussa ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Special Focus ◽  
Nano Drug Delivery ◽  
Medical Researchers ◽  
History Of ◽  
Overall Performance ◽  
Enhanced Stability

Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering anti-tumor agents with enhanced stability, durability and overall performance; especially when used along with targeting and triggering techniques. This work traces back the history of chemotherapy, addressing the main challenges that have encouraged the medical researchers to seek a sanctuary in nanotechnological-based drug delivery systems that are grafted with appropriate targeting techniques and drug release mechanisms. A special focus will be directed to acoustically triggered liposomes encapsulating doxorubicin.

Current HPLC Methods for Assay of Nano Drug Delivery Systems

2017 ◽  
Vol 17 (13) ◽  
pp. 1588-1594 ◽  
Author(s):  
Serife Evrim Kepekci Tekkeli ◽  
Mustafa Volkan Kiziltas
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Nano Drug Delivery
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