ChemInform Abstract: An Efficient Synthesis of a Key Intermediate for the Preparation of the Rhinovirus Protease Inhibitor AG7088 via Asymmetric Dianionic Cyanomethylation of N-Boc-L-(+)-glutamic Acid Dimethyl Ester.

ChemInform ◽  
2010 ◽  
Vol 32 (52) ◽  
pp. no-no
Author(s):  
Qingping Tian ◽  
Naresh K. Nayyar ◽  
et al. et al.
Keyword(s):  
Protease Inhibitor ◽  
Glutamic Acid ◽  
Dimethyl Ester ◽  
Efficient Synthesis ◽  
Acid Dimethyl Ester

Insulinotropic action of glutamic acid dimethyl ester

1994 ◽  
Vol 267 (4) ◽  
pp. E573-E584 ◽  
Author(s):  
A. Sener ◽  
I. Conget ◽  
J. Rasschaert ◽  
V. Leclercq-Meyer ◽  
M. L. Villanueva-Penacarrillo ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Insulin Release ◽  
Dimethyl Ester ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
O2 Uptake ◽  
Acid Dimethyl Ester ◽  
Insulin Dependent ◽  
Early Fall ◽  
Stimulate Insulin Release

Glutamic acid dimethyl ester (GME; 3.0–10.0 mM) enhanced insulin release evoked by 6.0–8.3 mM D-glucose, 1.0–10.0 mM L-leucine, or 5.0–10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, causing a shift to the left of the sigmoidal relationship between insulin output and D-glucose concentration. In the absence of D-glucose, GME also unmasked the insulinotropic potential of glibenclamide. In islets exposed to L-leucine, the insulinotropic action of GME coincided with an early fall and later increase in 86Rb outflow and augmentation of 45Ca outflow from prelabeled islets. The measurement of O2 uptake, NH4+ output, production of 14CO2 from islets prelabeled with [U-14C]palmitate, generation of 14C-labeled amino acids and 14CO2 from the dimethyl ester of either L-[1-14C]glutamic acid or L-[U-14C]glutamic acid, and D-[2-14C]glucose as well as D-[6-14C]glucose oxidation in the presence or absence of GME indicated that the latter ester was efficiently converted to L-glutamate and its further metabolites. The overall gain in O2 uptake represented the balance between GME oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous D-glucose. It is proposed that GME might represent a new tool to bypass beta-cell defects in D-glucose transport, phosphorylation, and further metabolism and, hence, to stimulate insulin release in experiments conducted in animal models of non-insulin-dependent diabetes mellitus.

The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester

2018 ◽  
Vol 1151 ◽  
pp. 218-222 ◽  
Author(s):  
Agnieszka Siebert ◽  
Grzegorz Cholewiński ◽  
Dorota Garwolińska ◽  
Adrian Olejnik ◽  
Janusz Rachoń ◽  
...  
Keyword(s):  
Malonic Acid ◽  
Dimethyl Ester ◽  
Acid Dimethyl Ester

ChemInform Abstract: Regioselective Addition of Cyclic Nitrones to Feist′s Acid Dimethyl Ester.

ChemInform ◽  
2012 ◽  
Vol 43 (50) ◽  
pp. no-no
Author(s):  
A. P. Molchanov ◽  
T. Q. Tran ◽  
R. R. Kostikov
Keyword(s):  
Dimethyl Ester ◽  
Cyclic Nitrones ◽  
Acid Dimethyl Ester ◽  
Regioselective Addition
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