Optical imaging methods in medicine: how can we escape the plausibility trap?

2018 ◽  
Vol 63 (5) ◽  
pp. 507-510
Author(s):  
Werner Nahm ◽  
Christoph Hornberger ◽  
Ute Morgenstern ◽  
Stephan B. Sobottka
Keyword(s):  
Optical Imaging ◽  
Imaging Methods

scholarly journals Assessment of Endothelin-A Receptor Expression in Subcutaneous and Orthotopic Thyroid Carcinoma Xenografts in Vivo Employing Optical Imaging Methods

Endocrinology ◽  
2012 ◽  
Vol 153 (6) ◽  
pp. 2907-2918 ◽  
Author(s):  
Katrin Büther ◽  
Matthijs G. Compeer ◽  
Jo G. R. De Mey ◽  
Otmar Schober ◽  
Michael Schäfers ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Optical Imaging ◽  
Near Infrared ◽  
Functional Performance ◽  
Thyroid Tumor ◽  
Receptor Expression ◽  
Imaging Methods ◽  
Carcinoma Cell Lines ◽  
Isolated Artery

Endothelin (ET) receptor dysregulation has been described in a number of pathophysiological processes, including cardiovascular disorders, renal failure, and cancer. The aim of this study was to evaluate the expression of the ET-A receptor (ETAR) in murine models of thyroid carcinoma using optical imaging methods. A recently developed near-infrared fluorescent tracer was first assessed in isolated artery preparations for its functional performance in comparison with known ETAR antagonists BQ123 and PD156707. Before evaluation of the tracer in vivo, different thyroid carcinoma cell lines were characterized with respect to their ET receptor expression by RT-PCR and autoradiography. In vivo, sc and orthotopic papillary thyroid tumor xenografts were clearly visualized by fluorescence reflectance imaging and fluorescence-mediated tomography up to 48 h after injection of the tracer. Binding specificity of the probe was demonstrated by predosing with PD156707 as a competing inhibitor. In conclusion, optical imaging with a fluorescent ETAR tracer allows the noninvasive imaging of tumor-associated ETAR expression in vivo. In the future, this technique may help surgeons to evaluate lesion dimensions in intraoperative settings (e.g. thyroidectomy).

Cellular Detection of G‐Quadruplexes by Optical Imaging Methods

2017 ◽  
Vol 76 (1) ◽  
Author(s):  
Souheila Amor ◽  
Sunny Y. Yang ◽  
Judy M. Y. Wong ◽  
David Monchaud
Keyword(s):  
Optical Imaging ◽  
Imaging Methods

Larger depth of field for optical imaging methods

2007 ◽  
Author(s):  
J. J. Wang ◽  
S. G. Sang ◽  
Z. Wang ◽  
X. T. Mo ◽  
W. Y. Liu
Keyword(s):  
Optical Imaging ◽  
Depth Of Field ◽  
Imaging Methods

Agreement among 3 Optical Imaging Methods for the Assessment of Optic Disc Topography

Ophthalmology ◽  
2005 ◽  
Vol 112 (12) ◽  
pp. 2149-2156 ◽  
Author(s):  
Esther M. Hoffmann ◽  
Christopher Bowd ◽  
Felipe A. Medeiros ◽  
Catherine Boden ◽  
Franz H. Grus ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Optic Disc ◽  
Imaging Methods

Planar backward projection of transient fields obtained from optical imaging methods

1998 ◽  
Vol 103 (5) ◽  
pp. 3048-3048
Author(s):  
Gregory Clement ◽  
Ruiming Liu ◽  
Stephen Letcher ◽  
Peter Stepanishen
Keyword(s):  
Optical Imaging ◽  
Imaging Methods

Optical imaging methods in turbid biological media

1996 ◽  
Author(s):  
Kaihua Wu ◽  
Zhenjiang He ◽  
Lili Xie ◽  
Yongcai Guo ◽  
Guanling Yang
Keyword(s):  
Optical Imaging ◽  
Biological Media ◽  
Imaging Methods
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