scholarly journals Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species‐specific regulation of blood pressure

2020 ◽  
Vol 8 (4) ◽  
Author(s):  
Carlo J. Mercado ◽  
Xiaochun Wang ◽  
Paul R. Grimm ◽  
Paul A. Welling ◽  
Yen‐Pei C. Chang
Keyword(s):  
Blood Pressure ◽  
Specific Regulation ◽  
Species Specific ◽  
Identification And Characterization ◽  
Regulation Of Blood Pressure ◽  
Human And Mouse

P2Y13: Identification and Characterization of a Novel Gαi-Coupled ADP Receptor from Human and Mouse

2002 ◽  
Vol 301 (2) ◽  
pp. 705-713 ◽  
Author(s):  
Fang L. Zhang ◽  
Lin Luo ◽  
Eric Gustafson ◽  
Kyle Palmer ◽  
Xudong Qiao ◽  
...  
Keyword(s):  
Adp Receptor ◽  
Identification And Characterization ◽  
Human And Mouse

scholarly journals Identification and Characterization of Benomyl-Resistant and -Sensitive Populations of Colletotrichum gloeosporioides from Statice (Limonium spp.)

2006 ◽  
Vol 96 (5) ◽  
pp. 542-548 ◽  
Author(s):  
Marcel Maymon ◽  
Aida Zveibil ◽  
Shimon Pivonia ◽  
Dror Minz ◽  
Stanley Freeman
Keyword(s):  
Colletotrichum Gloeosporioides ◽  
Sequence Analyses ◽  
Specific Primers ◽  
Tubulin Genes ◽  
Colletotrichum Spp ◽  
Polymerase Chain ◽  
Species Specific ◽  
Identification And Characterization ◽  
Propagation Material

Sixty-four isolates of Colletotrichum gloeosporioides were isolated from infected Limonium spp. cultivated in 12 different locations in Israel. All isolates were identified as belonging to the C. gloeosporioides complex by species-specific primers. Of these isolates, 46 were resistant to benomyl at 10 μg/ml and 18 were sensitive to this concentration of fungicide. Based on arbitrarily primed polymerase chain reaction of all isolates and internal transcribed spacer-1 sequence analyses of 12 selected isolates, the benomyl-resistant and -sensitive populations belong to two distinct genotypes. Sequence analyses of the β-tubulin genes, TUB1 and TUB2, of five sensitive and five resistant representative isolates of C. gloeosporioides from Limonium spp. revealed that the benomyl-resistant isolates had an alanine substitute instead of a glutamic acid at position 198 in TUB2. All data suggest that the resistant and sensitive genotypes are two independent and separate populations. Because all Limonium plant propagation material is imported from various geographic regions worldwide, and benomyl is not applied to this crop or for the control of Colletotrichum spp. in Israel, it is presumed that plants are bearing quiescent infections from the points of origin prior to arrival.

scholarly journals Sex and Body Mass Index Specific Regulation of Blood Pressure by CYP19A1 Gene Variants

Hypertension ◽  
2007 ◽  
Vol 50 (5) ◽  
pp. 884-890 ◽  
Author(s):  
Reposo Ramirez-Lorca ◽  
Antonio Grilo ◽  
Maria Teresa Martinez-Larrad ◽  
Luis Manzano ◽  
Francisco Javier Serrano-Hernando ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Body Mass ◽  
Gene Variants ◽  
Specific Regulation ◽  
Regulation Of Blood Pressure

scholarly journals Identification and characterization of the 2D6 and Mr 23000 antigens on the plasma membrane of rat spermatozoa

1987 ◽  
Vol 241 (2) ◽  
pp. 353-360 ◽  
Author(s):  
R Jones ◽  
C R Brown
Keyword(s):  
Plasma Membrane ◽  
Antigenic Determinant ◽  
Egg Recognition ◽  
Western Blots ◽  
One Dimensional ◽  
Antigen Present ◽  
Membrane Bound ◽  
Species Specific ◽  
Identification And Characterization

Previous investigations [Jones, Brown, von Glos & Gaunt (1985) Exp. Cell Res. 156, 31-44] have demonstrated the appearance of a new antigenic determinant (recognized by monoclonal antibody 2D6) on the plasma membrane of rat spermatozoa during post-testicular maturation in the epididymis. Identification of the 2D6 antigen on Western blots from one-dimensional SDS/polyacrylamide gels revealed that it co-migrated with a membrane protein (designated Mr 23,000 antigen) present on testicular and immature germ cells, suggesting that one antigen might be a modified version of the other. In the present work, however, we demonstrate that, although they have similar Mr and are present in soluble and membrane-bound forms, the 2D6 and Mr 23,000 antigens are biochemically and immunologically distinct molecules. The properties of the antigens are described and compared. The Mr 23,000 antigen is present on both testicular and cauda epididymidal spermatozoa, has a pI of 6.1, contains no detectable carbohydrate, is not tissue-specific and is degraded by V8 protease. By contrast, the 2D6 antigen is glycosylated, has a broad pI from 4.5 to 6.1, is tissue- and species-specific and is resistant to digestion with V8 protease. Its role in sperm-egg recognition is discussed.

Identification and Characterization of the Human and Mouse SLC19A3 Gene: A Novel Member of the Reduced Folate Family of Micronutrient Transporter Genes

2000 ◽  
Vol 71 (4) ◽  
pp. 581-590 ◽  
Author(s):  
James D. Eudy ◽  
Ofer Spiegelstein ◽  
Robert C. Barber ◽  
Bogdan J. Wlodarczyk ◽  
Jeffrey Talbot ◽  
...  
Keyword(s):  
Identification And Characterization ◽  
Human And Mouse

Molecular Identification and Characterization of Chicken Parvovirus from Indian Chicken and Association with Runting and Stunting Syndrome

2020 ◽  
Author(s):  
M. Pradeep ◽  
M. R. Reddy ◽  
T. R. Kannaki
Keyword(s):  
Sequence Analysis ◽  
Close Association ◽  
Enteric Viruses ◽  
Chain Reaction ◽  
Specific Primers ◽  
Avian Nephritis Virus ◽  
Etiological Agents ◽  
Species Specific ◽  
Identification And Characterization

Background: Runting-stunting syndrome (RSS) in chickens is a worldwide problem, attributed with several etiological agents. The present study aimed to identify the association of enteric viruses with RSS in different chicken flocks. Methods: Intestinal samples from 14 flocks of chicken of different age and breed and with or without RSS were collected randomly from necropsy samples, isolated nucleic acids, and screened for major enteric viruses by Polymerised chain reaction (PCR), using species-specific primers. Result: Chicken Parvovirus (ChPV) was identified in 100% of the flocks with RSS, in two of which ChPV alone was detected. While in others it was associated with Avian nephritis virus, Avian Rotavirus, Chicken astrovirus, and Fowl adenovirus in 80%, 50%, 30% and 10% flocks, respectively. RSS was reproduced and isolated ChPV by chicken embryo inoculation using the samples from ChPV alone infected cases. Sequence analysis of ChPV revealed closer association with Ecuodor isolates than the Asian isolates. The results indicated the presence of ChPV in Indian chicken flocks and its close association with RSS.

scholarly journals Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

2002 ◽  
Vol 158 (2) ◽  
pp. 235-246 ◽  
Author(s):  
J.-C. Bourdon ◽  
J. Renzing ◽  
P.L. Robertson ◽  
K.N. Fernandes ◽  
D.P. Lane
Keyword(s):  
Nuclear Membrane ◽  
Growth Arrest ◽  
Dependent Manner ◽  
Γ Irradiation ◽  
Expression Of Genes ◽  
Proapoptotic Protein ◽  
Identification And Characterization ◽  
Human And Mouse

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis.

Sign in / Sign up

Export Citation Format

Share Document