P2Y13: Identification and Characterization of a Novel Gαi-Coupled ADP Receptor from Human and Mouse

2002 ◽  
Vol 301 (2) ◽  
pp. 705-713 ◽  
Author(s):  
Fang L. Zhang ◽  
Lin Luo ◽  
Eric Gustafson ◽  
Kyle Palmer ◽  
Xudong Qiao ◽  
...  
Keyword(s):  
Adp Receptor ◽  
Identification And Characterization ◽  
Human And Mouse

Identification and Characterization of the Human and Mouse SLC19A3 Gene: A Novel Member of the Reduced Folate Family of Micronutrient Transporter Genes

2000 ◽  
Vol 71 (4) ◽  
pp. 581-590 ◽  
Author(s):  
James D. Eudy ◽  
Ofer Spiegelstein ◽  
Robert C. Barber ◽  
Bogdan J. Wlodarczyk ◽  
Jeffrey Talbot ◽  
...  
Keyword(s):  
Identification And Characterization ◽  
Human And Mouse

scholarly journals Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane

2002 ◽  
Vol 158 (2) ◽  
pp. 235-246 ◽  
Author(s):  
J.-C. Bourdon ◽  
J. Renzing ◽  
P.L. Robertson ◽  
K.N. Fernandes ◽  
D.P. Lane
Keyword(s):  
Nuclear Membrane ◽  
Growth Arrest ◽  
Dependent Manner ◽  
Γ Irradiation ◽  
Expression Of Genes ◽  
Proapoptotic Protein ◽  
Identification And Characterization ◽  
Human And Mouse

p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we compared, by differential display, the expression of genes in spleen or thymus of normal and p53 nullizygote mice after γ-irradiation of whole animals. We report the identification and characterization of human and mouse Scotin homologues, a novel gene directly transactivated by p53. The Scotin protein is localized to the ER and the nuclear membrane. Scotin can induce apoptosis in a caspase-dependent manner. Inhibition of endogenous Scotin expression increases resistance to p53-dependent apoptosis induced by DNA damage, suggesting that Scotin plays a role in p53-dependent apoptosis. The discovery of Scotin brings to light a role of the ER in p53-dependent apoptosis.

scholarly journals Identification and Characterization of Human and Mouse Ovastacin

2004 ◽  
Vol 279 (25) ◽  
pp. 26627-26634 ◽  
Author(s):  
Víctor Quesada ◽  
Luis M. Sánchez ◽  
Jesús Álvarez ◽  
Carlos López-Otín
Keyword(s):  
Identification And Characterization ◽  
Human And Mouse

KCNE1-like Gene Is Deleted in AMME Contiguous Gene Syndrome: Identification and Characterization of the Human and Mouse Homologs

Genomics ◽  
1999 ◽  
Vol 60 (3) ◽  
pp. 251-257 ◽  
Author(s):  
Monica Piccini ◽  
Francesca Vitelli ◽  
Marco Seri ◽  
Luis J.V. Galietta ◽  
Oscar Moran ◽  
...  
Keyword(s):  
Contiguous Gene ◽  
Identification And Characterization ◽  
Human And Mouse

Identification and Characterization of an IgG Binding Protein in the Secretion of the Rat Coagulating Gland

2002 ◽  
Vol 383 (12) ◽  
pp. 1959-1965 ◽  
Author(s):  
B. Wilhelm ◽  
C. Keppler ◽  
A. Henkeler ◽  
M. Schilli-Westermann ◽  
D. Linder ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Nucleotide Sequence ◽  
Binding Protein ◽  
Sequence Analyses ◽  
Reducing Conditions ◽  
Igg Binding ◽  
Identification And Characterization ◽  
Human And Mouse ◽  
Coagulating Gland

AbstractA merocrine released protein (named 115k protein) was highly enriched from the secretion of the rat coagulating gland. The protein has a molecular mass of 115 kDa as calculated by SDSPAGE under reducing conditions. Furthermore, the 115 kDa protein is glycosylated, and carries Man, GlcNAc, Gal, Fuc and sialic acid residues. For identification, Nterminal amino acid and nucleotide sequence analyses were performed. The sequences obtained showed 86 to 100% identity with human and mouse IgGFc binding proteins. The functional capacity of IgG binding of the 115 kDa protein was shown by overlay experiments, indicating its membership in the IgG binding protein family.

Identification and Characterization of the Genes Encoding Human and Mouse Osteoactivin

2003 ◽  
Vol 13 (2-4) ◽  
pp. 16 ◽  
Author(s):  
Thomas A. Owen ◽  
Steven L. Smock ◽  
S. Prakash ◽  
L. Pinder ◽  
D. Brees ◽  
...  
Keyword(s):  
Genes Encoding ◽  
Identification And Characterization ◽  
Human And Mouse
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