scholarly journals Effect of 8-week leucine supplementation and resistance exercise training on muscle hypertrophy and satellite cell activation in rats

2018 ◽  
Vol 6 (12) ◽  
pp. e13725 ◽  
Author(s):  
Chang Hyun Lim ◽  
Ju Hyun Gil ◽  
Helong Quan ◽  
Dang Ha Viet ◽  
Chang Keun Kim
Keyword(s):  
Exercise Training ◽  
Resistance Exercise ◽  
Satellite Cell ◽  
Muscle Hypertrophy ◽  
Cell Activation ◽  
Resistance Exercise Training ◽  
Leucine Supplementation ◽  
Satellite Cell Activation

Muscle Transcriptional Networks Linked to Resistance Exercise Training Hypertrophic Response Heterogeneity

2021 ◽  
Author(s):  
Kaleen M. Lavin ◽  
Margaret B. Bell ◽  
Jeremy S. McAdam ◽  
Bailey D Peck ◽  
R. Grace Walton ◽  
...  
Keyword(s):  
Gene Expression ◽  
Exercise Training ◽  
Resistance Exercise ◽  
Muscle Hypertrophy ◽  
Thigh Muscle ◽  
Secondary Outcome ◽  
Transcriptional Networks ◽  
Type I ◽  
Resistance Exercise Training ◽  
Hypertrophic Response

The skeletal muscle hypertrophic response to resistance exercise training (RT) is highly variable across individuals. The molecular underpinnings of this heterogeneity are unclear. This study investigated transcriptional networks linked to RT-induced muscle hypertrophy, classified as (i) predictive of hypertrophy, (ii) responsive to RT independent of muscle hypertrophy, or (iii) plastic with hypertrophy. Older adults (n=31, 18F/13M, 70±4y) underwent 14-wk RT (3d/wk, alternating high-low-high intensity). Muscle hypertrophy was assessed by pre- to post-RT change in mid-thigh muscle cross-sectional area (CSA) [computed tomography (CT), primary outcome], and thigh lean mass [dual-energy x-ray absorptiometry (DXA), secondary outcome]. Transcriptome-wide poly-A RNA-seq was performed on vastus lateralis tissue collected pre- (n=31) and post-RT (n=22). Prediction networks (using only baseline RNAseq) were identified by Weighted Gene Correlation Network Analysis (WGCNA). To identify Plasticity networks, WGCNA change indices for paired samples were calculated and correlated to changes in muscle size outcomes. Pathway-Level Information ExtractoR (PLIER) was applied to identify Response networks and link genes to biological annotation. Predictionnetworks (n=6) confirmed transcripts previously connected to resistance/ aerobic training adaptations in the MetaMEx database while revealing novel member genes that should fuel future research to understand the influence of baseline muscle gene expression on hypertrophy. Response networks (n=6) indicated RT-induced increase in aerobic metabolism and reduced expression of genes associated with spliceosome biology and type-I myofibers. A single exploratory Plasticity network was identified. Findings support that inter-individual differences in baseline gene expression may contribute more than RT-induced changes in gene networks to muscle hypertrophic response heterogeneity.

Delayed Satellite Cell Activation in Relation to Myostatin Expression Following Acute Resistance Exercise in Older and Younger Adults

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 52-53
Author(s):  
Bryon R. McKay ◽  
Daniel I. Ogborn ◽  
Leeann Bellamy ◽  
Mark A. Tarnopolsky ◽  
Gianni Parise
Keyword(s):  
Resistance Exercise ◽  
Satellite Cell ◽  
Cell Activation ◽  
Younger Adults ◽  
Satellite Cell Activation
Sign in / Sign up

Export Citation Format

Share Document