Treatment of Older Women With Endometrial Cancer: Improving Outcomes With Personalized Care

2016 ◽  
Vol 36 ◽  
pp. 164-174 ◽  
Author(s):  
Linda Duska ◽  
Armin Shahrokni ◽  
Melanie Powell
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Personalized Care

Treatment of Older Women With Endometrial Cancer: Improving Outcomes With Personalized Care

2016 ◽  
pp. 164-174 ◽  
Author(s):  
Linda Duska ◽  
Armin Shahrokni ◽  
Melanie Powell
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Practical Implication ◽  
Gynecologic Cancer ◽  
Tumor Biology ◽  
Multidisciplinary Care ◽  
Technical Aspect ◽  
Older Patient ◽  
Personalized Care ◽  
Care Surgery

Endometrial cancer is the most common gynecologic cancer, and with a median age of 62 at diagnosis, it affects a significant number of older women. With increasing age and obesity rates in the world’s population, there is an anticipated concomitant increase in older women with endometrial cancer. Older women are more likely to die of endometrial cancer compared with younger patients. Reasons for this include more aggressive tumor biology, less favorable clinicopathologic features, and more advanced disease. Other factors, however, such as reluctance to offer surgical treatment to the older patient and increased complications of treatment are likely to be important. Management of endometrial cancer requires multidisciplinary care (surgery, radiation therapy, and systemic therapy). For each treatment, the feasibility (related to technical aspect of the procedure/treatment), side effects and safety (related to older-patient factors), and the overall benefit as it pertains to older women with endometrial cancer should be assessed carefully with a multidisciplinary approach. Despite the importance of these issues, the data are limited to answer these issues with clarity. In this article, we will review each treatment modality for older women with endometrial cancer. We will introduce the components of comprehensive geriatric assessment and their practical implication for older women with cancer in general and older women with endometrial cancer specifically.

Predicting Endometrial Cancer Among Older Women Who Present With Abnormal Vaginal Bleeding

1995 ◽  
Vol 50 (11) ◽  
pp. 779-780
Author(s):  
Sarah Feldman ◽  
Francis E. Cook ◽  
Bernard L. Harlow ◽  
Ross S. Berkowitz
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Vaginal Bleeding ◽  
Abnormal Vaginal Bleeding

EP477 Laparoscopic versus abdominal surgery for 70-years and older women with endometrial cancer

2019 ◽  
Author(s):  
I Berlev ◽  
Y Trifanov ◽  
Z Ibragimov ◽  
O Smirnova ◽  
K Guseinov ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Abdominal Surgery ◽  
Older Women

Predicting Endometrial Cancer among Older Women Who Present with Abnormal Vaginal Bleeding

1995 ◽  
Vol 56 (3) ◽  
pp. 376-381 ◽  
Author(s):  
Sarah Feldman ◽  
E.Francis Cook ◽  
Bernard L. Harlow ◽  
Ross S. Berkowitz
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Vaginal Bleeding ◽  
Abnormal Vaginal Bleeding

scholarly journals 4th symposium on primary breast cancer in older women. Theme: putting personalized care into practice (Held: 3 March 2017)

2017 ◽  
Vol 6 (2) ◽  
pp. 33-53
Author(s):  
Kwok-Leung Cheung ◽  
David Morgan ◽  
Etienne Brain ◽  
Philip Poortmans ◽  
Ruth Parks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Personalized Care

Surgical and survival outcomes in older women with endometrial cancer treated by laparoscopy

2009 ◽  
pp. 1 ◽  
Author(s):  
Gabriele Siesto ◽  
Stefano Uccella ◽  
Fabio Ghezzi ◽  
Antonella Cromi ◽  
Francesca Zefiro ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Survival Outcomes

Clinicopathological Features and Survival in Young Taiwanese Women With Endometrial Carcinoma

2014 ◽  
Vol 24 (6) ◽  
pp. 1015-1020 ◽  
Author(s):  
Hei-Yu Lau ◽  
Yi-Jen Chen ◽  
Ming-Shyen Yen ◽  
Kuan-Chong Chao ◽  
Ru-Fen Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Body Mass Index ◽  
Endometrial Cancer ◽  
Older Women ◽  
Disease Free Survival ◽  
Clinicopathological Features ◽  
Free Survival ◽  
Younger Women ◽  
Primary Ovarian Cancer ◽  
Disease Free

ObjectiveThe aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).MethodsWe conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.ResultsOne hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9–121.7 months). Low body mass index (P< 0.001), nulliparity (P< 0.001), less medical illness (P< 0.001), synchronous primary ovarian cancer (P= 0.001), endometrioid type (P= 0.005), low tumor grade (P< 0.001), no para-aortic lymph node involvement (P< 0.047), less myometrial invasion (P< 0.001), and no vascular space invasion (P= 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P= 0.006) and overall survival (P= 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P= 0.004) and overall survival (P= 0.050).ConclusionsNulliparity, body mass index less than or equal to 23 kg/m2, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.

Endometrial Cancer: Is This a New Disease?

2017 ◽  
pp. 435-442 ◽  
Author(s):  
Kathleen Moore ◽  
Molly A. Brewer
Keyword(s):  
Endometrial Cancer ◽  
Mortality Rate ◽  
Conservative Treatment ◽  
Older Women ◽  
Age Of Onset ◽  
New Disease ◽  
Lifestyle Modifications ◽  
Younger Women ◽  
Diet And Exercise

The incidence of endometrial cancer is increasing, and the age of onset is younger than in prior years. Although endometrial cancer still occurs more commonly in older women, for whom the mortality rate is increasing, it also is being diagnosed in younger and younger women. The underlying cause of the increase in incidence is the epidemic of obesity and the resulting hyperinsulinemia. Conservative treatment may be indicated for younger women who wish to retain their fertility. Lifestyle modifications such as diet and exercise can modulate the risk of developing endometrial cancer as well as prevent recurrence and other comorbidities associated with obesity.

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