scholarly journals 4th symposium on primary breast cancer in older women. Theme: putting personalized care into practice (Held: 3 March 2017)

2017 ◽  
Vol 6 (2) ◽  
pp. 33-53
Author(s):  
Kwok-Leung Cheung ◽  
David Morgan ◽  
Etienne Brain ◽  
Philip Poortmans ◽  
Ruth Parks ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Personalized Care

scholarly journals Biological Characteristics and Clinical Outcome of Triple Negative Primary Breast Cancer in Older Women – Comparison with Their Younger Counterparts

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e100573 ◽  
Author(s):  
Binafsha M. Syed ◽  
Andrew R. Green ◽  
Christopher C. Nolan ◽  
David A. L. Morgan ◽  
Ian O. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Triple Negative ◽  
Biological Characteristics

scholarly journals A vision to optimise the management of primary breast cancer in older women

The Breast ◽  
2010 ◽  
Vol 19 (2) ◽  
pp. 153-155 ◽  
Author(s):  
K.L. Cheung ◽  
D.A.L. Morgan ◽  
L. Winterbottom ◽  
H. Richardson ◽  
I.O. Ellis ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Older Women ◽  
Primary Breast Cancer

scholarly journals EP.TH.275The role of amino acid transporters SLC1A5 and SLC3A2 in primary breast cancer in older women

2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Ruth Parks ◽  
Lutfi Alfarsi ◽  
Andrew Green ◽  
Kwok-Leung Cheung
Keyword(s):  
Breast Cancer ◽  
Amino Acid ◽  
Older Women ◽  
Primary Breast Cancer ◽  
Tumour Size ◽  
Glutamine Metabolism ◽  
Amino Acid Transporters ◽  
Younger Women ◽  
Er Status

Abstract Aims Breast cancer in older women has more favourable biology, compared to younger women. Increased glutamine metabolism is a hallmark of cancer. The prognostic role of amino acid transporters involved with glutamine flux, SLC1A5 and SLC3A2, has been shown in breast cancer in younger women. This study aimed to investigate the role of SLC1A5 and SLC3A2 in breast cancer in older women as possible prognostic markers. Methods Surgical specimens were obtained from an existing series of 1,758 older women (≥70 years) with primary breast cancer, treated in a single institution with long-term (37+ years) follow-up. Of this cohort, 813 had primary surgical treatment. As part of previous work, it was possible to construct good quality tissue microarrays (TMAs) in 575 cases. Immunohistochemical staining for SLC1A5 and SLC3A2 was performed. H-score was considered as a continuous variable as well as using positivity cut-offs of ≥ 45 for SLC1A5 and ≥15 for SLC3A2, using X-tile software. Association between H-score and tumour size, grade, ER status, local-recurrence-free-survival (LRFS), overall survival (OS) and breast-cancer-specific-survival (BCSS) was investigated. Results No correlation was seen between neither marker and LRFS, OS, or BCSS in older women with breast cancer. Both markers were associated with high tumour grade and negative ER status (both p < 0.001). Conclusions These findings are contrary to those found in younger women, where these amino acid transporters are associated with shorter BCSS. This may suggest that breast cancer in older women is less reliant on glutamine metabolism, which is consistent with an overall less aggressive phenotype.

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