Endometrial Cancer: Is This a New Disease?

2017 ◽  
pp. 435-442 ◽  
Author(s):  
Kathleen Moore ◽  
Molly A. Brewer
Keyword(s):  
Endometrial Cancer ◽  
Mortality Rate ◽  
Conservative Treatment ◽  
Older Women ◽  
Age Of Onset ◽  
New Disease ◽  
Lifestyle Modifications ◽  
Younger Women ◽  
Diet And Exercise

The incidence of endometrial cancer is increasing, and the age of onset is younger than in prior years. Although endometrial cancer still occurs more commonly in older women, for whom the mortality rate is increasing, it also is being diagnosed in younger and younger women. The underlying cause of the increase in incidence is the epidemic of obesity and the resulting hyperinsulinemia. Conservative treatment may be indicated for younger women who wish to retain their fertility. Lifestyle modifications such as diet and exercise can modulate the risk of developing endometrial cancer as well as prevent recurrence and other comorbidities associated with obesity.

Clinicopathological Features and Survival in Young Taiwanese Women With Endometrial Carcinoma

2014 ◽  
Vol 24 (6) ◽  
pp. 1015-1020 ◽  
Author(s):  
Hei-Yu Lau ◽  
Yi-Jen Chen ◽  
Ming-Shyen Yen ◽  
Kuan-Chong Chao ◽  
Ru-Fen Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Body Mass Index ◽  
Endometrial Cancer ◽  
Older Women ◽  
Disease Free Survival ◽  
Clinicopathological Features ◽  
Free Survival ◽  
Younger Women ◽  
Primary Ovarian Cancer ◽  
Disease Free

ObjectiveThe aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).MethodsWe conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.ResultsOne hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9–121.7 months). Low body mass index (P< 0.001), nulliparity (P< 0.001), less medical illness (P< 0.001), synchronous primary ovarian cancer (P= 0.001), endometrioid type (P= 0.005), low tumor grade (P< 0.001), no para-aortic lymph node involvement (P< 0.047), less myometrial invasion (P< 0.001), and no vascular space invasion (P= 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P= 0.006) and overall survival (P= 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P= 0.004) and overall survival (P= 0.050).ConclusionsNulliparity, body mass index less than or equal to 23 kg/m2, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.

Treatment of Older Women With Endometrial Cancer: Improving Outcomes With Personalized Care

2016 ◽  
pp. 164-174 ◽  
Author(s):  
Linda Duska ◽  
Armin Shahrokni ◽  
Melanie Powell
Keyword(s):  
Endometrial Cancer ◽  
Older Women ◽  
Practical Implication ◽  
Gynecologic Cancer ◽  
Tumor Biology ◽  
Multidisciplinary Care ◽  
Technical Aspect ◽  
Older Patient ◽  
Personalized Care ◽  
Care Surgery

Endometrial cancer is the most common gynecologic cancer, and with a median age of 62 at diagnosis, it affects a significant number of older women. With increasing age and obesity rates in the world’s population, there is an anticipated concomitant increase in older women with endometrial cancer. Older women are more likely to die of endometrial cancer compared with younger patients. Reasons for this include more aggressive tumor biology, less favorable clinicopathologic features, and more advanced disease. Other factors, however, such as reluctance to offer surgical treatment to the older patient and increased complications of treatment are likely to be important. Management of endometrial cancer requires multidisciplinary care (surgery, radiation therapy, and systemic therapy). For each treatment, the feasibility (related to technical aspect of the procedure/treatment), side effects and safety (related to older-patient factors), and the overall benefit as it pertains to older women with endometrial cancer should be assessed carefully with a multidisciplinary approach. Despite the importance of these issues, the data are limited to answer these issues with clarity. In this article, we will review each treatment modality for older women with endometrial cancer. We will introduce the components of comprehensive geriatric assessment and their practical implication for older women with cancer in general and older women with endometrial cancer specifically.

scholarly journals Utilization of preimplantation genetic testing in the USA

2021 ◽  
Author(s):  
Kaitlyn Roche ◽  
Catherine Racowsky ◽  
Joyce Harper
Keyword(s):  
Genetic Testing ◽  
Older Women ◽  
State Level ◽  
Oocyte Retrieval ◽  
Preimplantation Genetic Testing ◽  
Annual Increase ◽  
Younger Women ◽  
Live Birth Rates ◽  
Significant Difference ◽  
The Usa

Abstract Purpose To evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level. Methods This study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval. Results In the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001). Conclusions A growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.

scholarly journals What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women

2018 ◽  
Vol 7 (1) ◽  
pp. 131-138 ◽  
Author(s):  
Holli A. DeVon ◽  
Karen Vuckovic ◽  
Larisa A. Burke ◽  
Sahereh Mirzaei ◽  
Katherine Breen ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Older Women ◽  
Younger Women ◽  
Coronary Syndrome

Reported Intimacy and Dominance Gestures by Women in a Corporate Setting

1983 ◽  
Vol 52 (3) ◽  
pp. 1007-1010
Author(s):  
Aghop Der-Karabetian ◽  
Eric Rico
Keyword(s):  
Marital Status ◽  
Older Women ◽  
Sexual Intimacy ◽  
Younger Women ◽  
Relationship Of ◽  
The Relationship ◽  
Effect Of Age

The study tested the relationship of reported intimacy and dominance gestures by women in a corporate setting. The effect of age and marital status was also examined. The reported frequencies of the two types of gestures were uncorrelated ( r = .28). However, dominance was reported more frequently ( M = 9.85, SD = 1.8) than sexual intimacy ( M = 5.76, SD = 3.1). The 34 younger women reported more dominance and less sexual intimacy than the 48 older women. Single persons reported being targets of more dominance gestures than the married, but the younger women reported less sexual intimacy. Possible explanations for the findings are discussed.

Maori fertility in a period of transition

1975 ◽  
Vol 7 (3) ◽  
pp. 345-352 ◽  
Author(s):  
A. V Zodgekar
Keyword(s):  
Older Women ◽  
Fertility Decline ◽  
Birth Rate ◽  
Crude Birth Rate ◽  
Rapid Urbanization ◽  
Younger Women ◽  
Low Level ◽  
Child Bearing ◽  
Age Patterns ◽  
Substantial Decline

SummaryAn analysis of Maori fertility shows that a transition from a high to a low level has begun. The crude birth rate has declined by nearly 28% during the period 1961–72; only a small part of this decline can be attributed to changes in the age–sex and marital status composition.A substantial decline in the fertility of older women has been observed and there are indications of the beginning of a major decline in the fertility of younger women. Since women aged 30–49 still account for 30% of total fertility there is enough potential for a further fertility decline in the later child-bearing years.Age patterns of fertility decline suggest that inter-marriage between Pakehas and Maoris is not a prime cause of the recent fertility decline. The factors which are thought to be responsible for this change in Maori fertility are rapid urbanization, a low level of infant mortality and an increase in the overall level of education.A further decline in Maori fertility will depend on the continuation of the tendency in fertility among the younger women.

scholarly journals Mortality from endometrial cancer in female population of Belgrade

2004 ◽  
Vol 61 (3) ◽  
pp. 267-272
Author(s):  
Vesna Pantovic ◽  
Mirjana Jarebinski ◽  
Tatjana Pekmezovic ◽  
Anita Knezevic ◽  
Darija Kisic
Keyword(s):  
Endometrial Cancer ◽  
Mortality Rate ◽  
Malignant Tumors ◽  
Age Groups ◽  
Mortality Rates ◽  
Mortality Decline ◽  
Female Population ◽  
Average Percentage ◽  
Standardized Mortality Rate

Data about mortality from malignant tumors of endometrium were analyzed in the Belgrade area during the period 1975-2000. The obtained results showed that the average percentage of endometrial cancer in mortality structure from all the cancers of female population was 2.65%. During the observed 26-years period, malignant tumors of endometrium constituted 17.38% of all the tumors of gynecological localization. The standardized mortality rate in 1975 (population worldwide used as a standard) 7.06/100 000 population while in 2000 it was 1.78/100 000 population, respectively, which showed almost fourfold mortality decline during the observed period (y=4.72-0.16x). A trend of declining risk of dying from endometrial cancer was present in all the age groups. The obtained results indicated that in the observed period the average mortality rates ranged from 0.14/100 000 population in females aged up to 34 years (y=0.30-0.01x), and reached the highest value in females aged 65-74 years (14.57/100 000; y=23.43-0.66x), and 75 years of age and over (19.62/100 000; y=31.17-0.85x).

scholarly journals Neonatal intestinal obstruction: report

2000 ◽  
Vol 6 (1) ◽  
pp. 187-193
Author(s):  
G. A. Nasir ◽  
S. Rahma ◽  
A. H. Kadim
Keyword(s):  
Mortality Rate ◽  
Conservative Treatment ◽  
Intestinal Obstruction ◽  
Imperforate Anus ◽  
Surgical Intervention ◽  
Duodenal Atresia ◽  
Colonic Atresia ◽  
Neonatal Intestinal Obstruction ◽  
Age Range ◽  
Surgical Unit

We reviewed 36 cases of neonatal intestinal obstruction admitted to our surgical unit over a 10-year period, 1986-1996, for surgical intervention following the failure of conservative treatment. There were more males than females and the age range was 12 hours-26 days. Imperforate anus was the main cause of the obstruction [27.8%] followed by duodenal atresia [13.9%] and colonic atresia and meconium ileus [11.1% each]. There were 8 deaths following surgery [22% mortality rate], the main causes being aspiration pneumonia, septicaemia and hypothermia

The treatment of spontaneous intracerebral hemorrhage

1989 ◽  
Vol 70 (5) ◽  
pp. 755-758 ◽  
Author(s):  
Seppo Juvela ◽  
Olli Heiskanen ◽  
Antti Poranen ◽  
Simo Valtonen ◽  
Timo Kuurne ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Conservative Treatment ◽  
Intracerebral Hematoma ◽  
Content Type ◽  
Conservative Group ◽  
Level Of Consciousness ◽  
A Prospective Study ◽  
To Receive ◽  
Surgical Group

✓ In a prospective study, 52 patients with a spontaneous supratentorial intracerebral hematoma (ICH) were randomly assigned to receive emergency surgery or conservative treatment within 48 hours after the bleed. Patients with a decreased level of consciousness and/or a severe neurological deficit were admitted to the study. The overall mortality rate at 6 months was 42%: 10 (38%) of the 26 patients in the conservative group and 12 (46%) of the 26 in the surgical group. Six (20%) of the 30 survivors at 6 months were able to conduct their activities of daily living independently: five (31%) of the 16 patients in the conservative group and one (7%) of the 14 in the operative group. These differences are not statistically significant. The mortality rate of semicomatose or stuporous patients (Glasgow Coma Scale score 7 to 10) was statistically significantly lower in the surgical group (none of the four patients) than in the conservative group (four of five patients) (p < 0.05); however, all surviving patients in this subgroup were severely disabled. The study suggests that surgical treatment of this category of patients with ICH does not offer any definite advantage over conservative treatment. In semicomatose or stuporous patients, surgery may improve the length of survival, but the quality of life remains poor.

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