Activity of Iron Oxide Nanoparticles-Chitosan Composite on Bacterial Biofilm Formation

2018 ◽  
Author(s):  
Hanan Subhi ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Madhu Bala Sathyanarayanan ◽  
Reneta Balachandranath ◽  
Yuvasri Genji Srinivasulu ◽  
Sathish Kumar Kannaiyan ◽  
Guruprakash Subbiahdoss

Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel. Here, we studied the effect of gold and iron oxide nanoparticles on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We report that biofilm growth was reduced at higher concentrations of gold and iron-oxide nanoparticles compared to absence of nanoparticles. Thus nanoparticles with appropriate concentration could show significant reduction in biofilm formation.


2014 ◽  
Vol 1 (2) ◽  
pp. 123 ◽  
Author(s):  
Jennifer Borcherding ◽  
Jonas Baltrusaitis ◽  
Haihan Chen ◽  
Larissa Stebounova ◽  
Chia-Ming Wu ◽  
...  

2016 ◽  
Vol Volume 11 ◽  
pp. 6499-6506 ◽  
Author(s):  
Sifeng Shi ◽  
Jingfu Jia ◽  
XiaoKui Guo ◽  
Yaping Zhao ◽  
Desheng Chen ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Monica Thukkaram ◽  
Soundarya Sitaram ◽  
Sathish kumar Kannaiyan ◽  
Guruprakash Subbiahdoss

Biofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune cells. Application of metals in nanoscale is considered to resolve biofilm formation. Here we studied the effect of iron-oxide nanoparticles over biofilm formation on different biomaterial surfaces and pluronic coated surfaces. Bacterial adhesion for 30 min showed significant reduction in bacterial adhesion on pluronic coated surfaces compared to other surfaces. Subsequently, bacteria were allowed to grow for 24 h in the presence of different concentrations of iron-oxide nanoparticles. A significant reduction in biofilm growth was observed in the presence of the highest concentration of iron-oxide nanoparticles on pluronic coated surfaces compared to other surfaces. Therefore, combination of polymer brush coating and iron-oxide nanoparticles could show a significant reduction in biofilm formation.


2008 ◽  
Vol 24 (4) ◽  
pp. 676-683 ◽  
Author(s):  
Ajeet Kaushik ◽  
Raju Khan ◽  
Pratima R. Solanki ◽  
Pratibha Pandey ◽  
Javed Alam ◽  
...  

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