scholarly journals Antibacterial Efficacy of Iron-Oxide Nanoparticles against Biofilms on Different Biomaterial Surfaces

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Monica Thukkaram ◽  
Soundarya Sitaram ◽  
Sathish kumar Kannaiyan ◽  
Guruprakash Subbiahdoss
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Bacterial Adhesion ◽  
Biofilm Formation ◽  
Polymer Brush ◽  
Oxide Nanoparticles ◽  
Implant Surface ◽  
Biofilm Growth ◽  
Biomaterial Surfaces ◽  
Coated Surfaces

Biofilm growth on the implant surface is the number one cause of the failure of the implants. Biofilms on implant surfaces are hard to eliminate by antibiotics due to the protection offered by the exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune cells. Application of metals in nanoscale is considered to resolve biofilm formation. Here we studied the effect of iron-oxide nanoparticles over biofilm formation on different biomaterial surfaces and pluronic coated surfaces. Bacterial adhesion for 30 min showed significant reduction in bacterial adhesion on pluronic coated surfaces compared to other surfaces. Subsequently, bacteria were allowed to grow for 24 h in the presence of different concentrations of iron-oxide nanoparticles. A significant reduction in biofilm growth was observed in the presence of the highest concentration of iron-oxide nanoparticles on pluronic coated surfaces compared to other surfaces. Therefore, combination of polymer brush coating and iron-oxide nanoparticles could show a significant reduction in biofilm formation.

scholarly journals The Effect of Gold and Iron-Oxide Nanoparticles on Biofilm-Forming Pathogens

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Madhu Bala Sathyanarayanan ◽  
Reneta Balachandranath ◽  
Yuvasri Genji Srinivasulu ◽  
Sathish Kumar Kannaiyan ◽  
Guruprakash Subbiahdoss
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Immune Cells ◽  
Biofilm Formation ◽  
Bacterial Infections ◽  
Medical Applications ◽  
Oxide Nanoparticles ◽  
Biofilm Growth ◽  
Microbial Biofilms ◽  
Exopolymeric Substances

Microbial biofilms on biomaterial implants or devices are hard to eliminate by antibiotics due to their protection by exopolymeric substances that embed the organisms in a matrix, impenetrable for most antibiotics and immune-cells. Application of metals in their nanoparticulated form is currently considered to resolve bacterial infections. Gold and iron-oxide nanoparticles are widely used in different medical applications, but their utilisation to eradicate biofilms on biomaterials implants is novel. Here, we studied the effect of gold and iron oxide nanoparticles on Staphylococcus aureus and Pseudomonas aeruginosa biofilms. We report that biofilm growth was reduced at higher concentrations of gold and iron-oxide nanoparticles compared to absence of nanoparticles. Thus nanoparticles with appropriate concentration could show significant reduction in biofilm formation.

scholarly journals Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function

2014 ◽  
Vol 1 (2) ◽  
pp. 123 ◽  
Author(s):  
Jennifer Borcherding ◽  
Jonas Baltrusaitis ◽  
Haihan Chen ◽  
Larissa Stebounova ◽  
Chia-Ming Wu ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Iron Oxide ◽  
Antimicrobial Peptide ◽  
Iron Oxide Nanoparticles ◽  
Biofilm Formation ◽  
Oxide Nanoparticles

The effect of iron oxide nanoparticles on Bacillus subtilis biofilm, growth and viability

2017 ◽  
Vol 62 ◽  
pp. 231-240 ◽  
Author(s):  
Dinali Ranmadugala ◽  
Alireza Ebrahiminezhad ◽  
Merilyn Manley-Harris ◽  
Younes Ghasemi ◽  
Aydin Berenjian
Keyword(s):  
Bacillus Subtilis ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Biofilm Growth

Structural, Morphological, and Magnetic Characterization of Iron Oxide Nanoparticles Synthesized at Different Reaction Times via Thermal Decomposition Method

2021 ◽  
Vol 17 ◽  
Author(s):  
Nurcan Dogan ◽  
Fatmahan Ozel ◽  
Hasan Koten
Keyword(s):  
Thermal Decomposition ◽  
Iron Oxide ◽  
Reaction Time ◽  
Iron Oxide Nanoparticles ◽  
Decomposition Method ◽  
Reaction Times ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Thermal Decomposition Method ◽  
Coated Surfaces

Background: Superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition method. Methods: In this work, the properties of the nanoparticles synthesized at different reaction times were investigated. Fourier transformed infrared spectroscopy (FTIR) and thermal analysis were carried out to characterize oleate adsorbed on the surface of nanoparticles. Results: The oleate-coated surfaces were obtained for all samples and the amount of oleate on the surfaces of the particles changed with the change in reaction time. The size, size distribution, and shape of SPIONs were determined by x-ray diffraction (XRD), transmission electron microscopy (SEM), dynamic light scattering (DLS). It was seen that changing the reaction time was affected the shape of the nanoparticles, but almost the same size nanoparticles were obtained with the increase of reaction time. The sample's crystallite size of 12.5-14.2 nm achieved with XRD is in good agreement with the mean size of 15-16.4 that was obtained by TEM results. Maximum magnetic saturation of the sample was achieved at 3h reaction time. Conclusion: The magnetic properties of iron oxide nanoparticles were characterized by electron-spin resonance (ESR), and physical properties measurement system (PPMS). All samples showed superparamagnetic behaviors at room temperature.

scholarly journals Reduced Staphylococcus aureus biofilm formation in the presence of chitosan-coated iron oxide nanoparticles

2016 ◽  
Vol Volume 11 ◽  
pp. 6499-6506 ◽  
Author(s):  
Sifeng Shi ◽  
Jingfu Jia ◽  
XiaoKui Guo ◽  
Yaping Zhao ◽  
Desheng Chen ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biofilm Formation ◽  
Oxide Nanoparticles

scholarly journals New O-Aryl-Carbamoyl-Oxymino-Fluorene Derivatives with MI-Crobicidal and Antibiofilm Activity Enhanced by Combination with Iron Oxide Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3002
Author(s):  
Ilinca Margareta Vlad ◽  
Diana Camelia Nuță ◽  
Robert Viorel Ancuceanu ◽  
Miron Teodor Caproiou ◽  
Florea Dumitrascu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Inhibitory Effect ◽  
Magnetic Core ◽  
Oxide Nanoparticles ◽  
Antibiofilm Activity ◽  
Biofilm Growth ◽  
Growth State ◽  
Shell Nanostructures

Antimicrobial resistance is one of the major public health threats at the global level, urging the search for new antimicrobial molecules. The fluorene nucleus is a component of different bioactive compounds, exhibiting diverse pharmacological actions. The present work describes the synthesis, chemical structure elucidation, and bioactivity of new O-aryl-carbamoyl-oxymino-fluorene derivatives and the contribution of iron oxide nanoparticles to enhance the desired biological activity. The antimicrobial activity assessed against three bacterial and fungal strains, in suspension and biofilm growth state, using a quantitative assay, revealed that the nature of substituents on the aryl moiety are determinant for both the spectrum and intensity of the inhibitory effect. The electron-withdrawing inductive effect of chlorine atoms enhanced the activity against planktonic and adhered Staphylococcus aureus, while the +I effect of the methyl group enhanced the anti-fungal activity against Candida albicans strain. The magnetite nanoparticles have substantially improved the antimicrobial activity of the new compounds against planktonic microorganisms. The obtained compounds, as well as the magnetic core@shell nanostructures loaded with these compounds have a promising potential for the development of novel antimicrobial strategies.

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