scholarly journals A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease

2021 ◽  
Author(s):  
Hyeonseok Jeong ◽  
Jooyeon Jamie Im ◽  
Jong-Sik Park ◽  
Seung-Hee Na ◽  
Wonhye Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Pilot Clinical Study ◽  
Transcranial Focused Ultrasound

scholarly journals Extensive frontal focused ultrasound mediated blood–brain barrier opening for the treatment of Alzheimer’s disease: a proof-of-concept study

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
So Hee Park ◽  
Kyoungwon Baik ◽  
Seun Jeon ◽  
Won Seok Chang ◽  
Byoung Seok Ye ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontal Lobe ◽  
Blood Brain Barrier ◽  
Focused Ultrasound ◽  
Standardized Uptake Value ◽  
Brain Barrier ◽  
Cortical Region ◽  
Blood Brain ◽  
Bbb Opening

Abstract Background Focused ultrasound (FUS)-mediated blood–brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in clinical studies. This study was conducted to evaluate the safety, feasibility and potential benefits of repeated extensive BBB opening. Methods In this open-label, prospective study, six patients with Alzheimer’s disease (AD) were enrolled at Severance Hospital in Korea between August 2020 and September 2020. Five of them completed the study. FUS-mediated BBB opening, targeting the bilateral frontal lobe regions over 20 cm3, was performed twice at three-month intervals. Magnetic resonance imaging, 18F-Florbetaben (FBB) positron emission tomography, Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI) and comprehensive neuropsychological tests were performed before and after the procedures. Results FUS targeted a mean volume of 21.1 ± 2.7 cm3 and BBB opening was confirmed at 95.7% ± 9.4% of the targeted volume. The frontal-to-other cortical region FBB standardized uptake value ratio at 3 months after the procedure showed a slight decrease, which was statistically significant, compared to the pre-procedure value (− 1.6%, 0.986 vs1.002, P = 0.043). The CGA-NPI score at 2 weeks after the second procedure significantly decreased compared to baseline (2.2 ± 3.0 vs 8.6 ± 6.0, P = 0.042), but recovered after 3 months (5.2 ± 5.8 vs 8.6 ± 6.0, P = 0.89). No adverse effects were observed. Conclusions The repeated and extensive BBB opening in the frontal lobe is safe and feasible for patients with AD. In addition, the BBB opening is potentially beneficial for amyloid removal in AD patients.

Implication of Auditory Confounding in Interpreting Somatosensory and Motor Responses in Low-Intensity Transcranial Focused Ultrasound Stimulation

2021 ◽  
Author(s):  
Christine Park ◽  
Mengyue Chen ◽  
Taewon Kim
Keyword(s):  
Focused Ultrasound ◽  
Auditory Pathway ◽  
Localization Accuracy ◽  
Motor Responses ◽  
Non Invasive ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Transcranial Focused Ultrasound ◽  
Indirect Stimulation ◽  
Stimulation Of

Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a non-invasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals and humans acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.

scholarly journals O4-02-04: EXPLORING GUT MICROBIOTA AS A SOURCE OF POTENTIAL BIOMARKERS: INITIAL RESULTS FROM THE ANAVEX® 2-73 ALZHEIMER'S DISEASE CLINICAL STUDY

2019 ◽  
Vol 15 ◽  
pp. P1232-P1233
Author(s):  
Frédéric Parmentier ◽  
Adrien Etcheto ◽  
Christopher Missling ◽  
Coralie Williams ◽  
Mohammad Afshar
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Gut Microbiota ◽  
Initial Results ◽  
Potential Biomarkers

P2-541: A NON-PHARMACOLOGIC CLINICAL STUDY OF NURSING HOME RESIDENTS WITH ALZHEIMER'S DISEASE AND DEMENTIA USING TIMESLIPS

2006 ◽  
Vol 14 (7S_Part_17) ◽  
pp. P944-P944
Author(s):  
George P. Sillup ◽  
Eileen L. Sullivan ◽  
Ronald K. Klimberg ◽  
Lisa Slater ◽  
Roberto Muniz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nursing Home ◽  
Clinical Study ◽  
Nursing Home Residents

An Observational Clinical Study of the Efficacy and Tolerability of Donepezil in the Treatment of Alzheimer’s Disease

2003 ◽  
Vol 15 (4) ◽  
pp. 189-198 ◽  
Author(s):  
Klaus Hager ◽  
Pasquale Calabrese ◽  
Lutz Frölich ◽  
Claus Göbel ◽  
Frank M. Berger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study
Sign in / Sign up

Export Citation Format

Share Document