scholarly journals A precision medicine framework using artificial intelligence for the identification and confirmation of genomic biomarkers of response to an Alzheimer's disease therapy: Analysis of the blarcamesine (ANAVEX2‐73) Phase 2a clinical study

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Harald Hampel ◽  
Coralie Williams ◽  
Adrien Etcheto ◽  
Federico Goodsaid ◽  
Frédéric Parmentier ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Precision Medicine ◽  
Genomic Biomarkers ◽  
Disease Therapy

scholarly journals APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer’s

2021 ◽  
Vol 22 (3) ◽  
pp. 1244
Author(s):  
Anna Yang ◽  
Boris Kantor ◽  
Ornit Chiba-Falek
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Precision Medicine ◽  
Antisense Oligonucleotides ◽  
State Of The Art ◽  
Late Onset ◽  
Base Editing ◽  
Medical Need ◽  
New Frontier ◽  
Amyloid Cascade

Alzheimer’s disease (AD) has a critical unmet medical need. The consensus around the amyloid cascade hypothesis has been guiding pre-clinical and clinical research to focus mainly on targeting beta-amyloid for treating AD. Nevertheless, the vast majority of the clinical trials have repeatedly failed, prompting the urgent need to refocus on other targets and shifting the paradigm of AD drug development towards precision medicine. One such emerging target is apolipoprotein E (APOE), identified nearly 30 years ago as one of the strongest and most reproduceable genetic risk factor for late-onset Alzheimer’s disease (LOAD). An exploration of APOE as a new therapeutic culprit has produced some very encouraging results, proving that the protein holds promise in the context of LOAD therapies. Here, we review the strategies to target APOE based on state-of-the-art technologies such as antisense oligonucleotides, monoclonal antibodies, and gene/base editing. We discuss the potential of these initiatives in advancing the development of novel precision medicine therapies to LOAD.

Current opinion in Alzheimer's disease therapy by nanotechnology-based approaches

2017 ◽  
Vol 30 (2) ◽  
pp. 128-135 ◽  
Author(s):  
Shakeel Ahmed Ansari ◽  
Rukhsana Satar ◽  
Asma Perveen ◽  
Ghulam Md Ashraf
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Current Opinion ◽  
Disease Therapy

scholarly journals A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease

2021 ◽  
Author(s):  
Hyeonseok Jeong ◽  
Jooyeon Jamie Im ◽  
Jong-Sik Park ◽  
Seung-Hee Na ◽  
Wonhye Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Pilot Clinical Study ◽  
Transcranial Focused Ultrasound
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