Biosafety of low-intensity pulsed transcranial focused ultrasound brain stimulation: a human skull study

2021 ◽  
Author(s):  
Mengyue Chen ◽  
Chang Peng ◽  
Taewon Kim ◽  
Pratik Y. Chhatbar ◽  
Marie Muller ◽  
...  
Keyword(s):  
Brain Stimulation ◽  
Focused Ultrasound ◽  
Human Skull ◽  
Low Intensity ◽  
Transcranial Focused Ultrasound

scholarly journals Safety Review and Perspectives of Transcranial Focused Ultrasound Brain Stimulation

2021 ◽  
Vol 14 ◽  
Author(s):  
Wonhye Lee ◽  
Daniel S. Weisholtz ◽  
Gary E. Strangman ◽  
Seung-Schik Yoo
Keyword(s):  
Brain Stimulation ◽  
Focused Ultrasound ◽  
Safety Review ◽  
Transcranial Focused Ultrasound

scholarly journals A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease

2021 ◽  
Author(s):  
Hyeonseok Jeong ◽  
Jooyeon Jamie Im ◽  
Jong-Sik Park ◽  
Seung-Hee Na ◽  
Wonhye Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Study ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Pilot Clinical Study ◽  
Transcranial Focused Ultrasound

Implication of Auditory Confounding in Interpreting Somatosensory and Motor Responses in Low-Intensity Transcranial Focused Ultrasound Stimulation

2021 ◽  
Author(s):  
Christine Park ◽  
Mengyue Chen ◽  
Taewon Kim
Keyword(s):  
Focused Ultrasound ◽  
Auditory Pathway ◽  
Localization Accuracy ◽  
Motor Responses ◽  
Non Invasive ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Transcranial Focused Ultrasound ◽  
Indirect Stimulation ◽  
Stimulation Of

Low-intensity transcranial focused ultrasound (LI-tFUS) stimulation is a non-invasive neuromodulation tool that demonstrates high target localization accuracy and depth penetration. It has been shown to modulate activities in the primary motor and somatosensory cortex. Previous studies in animals and humans acknowledged the possibility of indirect stimulation of the peripheral auditory pathway that could confound the somatosensory and motor responses observed with LI-tFUS stimulation. Here, we discuss the implications and interpretations of auditory confounding in the context of neuromodulation.

scholarly journals Safety of transcranial focused ultrasound for human neuromodulation

2018 ◽  
Author(s):  
Wynn Legon ◽  
Priya Bansal ◽  
Leo Ai ◽  
Jerel K. Mueller ◽  
Gregg Meekins ◽  
...  
Keyword(s):  
Neck Pain ◽  
Focused Ultrasound ◽  
Neuronal Excitability ◽  
Acoustic Energy ◽  
Full Potential ◽  
University Of Minnesota ◽  
Serious Adverse Events ◽  
Low Intensity ◽  
Transcranial Focused Ultrasound

AbstractBackgroundLow intensity transcranial focused ultrasound (tFUS) is a new method of non-invasive neuromodulation that uses acoustic energy to affect neuronal excitability. tFUS offers high spatial resolution and adjustable focal lengths for precise neuromodulation of discrete regions in the human brain. Before the full potential of low intensity ultrasound for research and clinical application can be investigated, data on the safety of this technique is indicated.Objective/HypothesisTo provide an initial evaluation of the safety of tFUS for human neuromodulation through participant report and neurological assessment surrounding pilot investigation of tFUS for neuromodulation.MethodsParticipants (N = 120) that were enrolled in one of seven human ultrasound neuromodulation studies at the University of Minnesota (2015 – 2017) were queried to complete a follow-up Participant Report of Symptoms questionnaire assessing their self-reported experience and tolerance to participation in tFUS research and the perceived relation of symptoms to tFUS.ResultsA total of 64/120 participant (53%) responded to follow-up requests to complete the Participant Report of Symptoms questionnaire. During the conduct of the seven studies in this report, none of the participants experienced serious adverse effects. From the post-hoc assessment of safety using the questionnaire, 7/64 reported mild to moderate symptoms, that were perceived as ‘possibly’ or ‘probably’ related to participation in tFUS experiments. These reports included neck pain, problems with attention, muscle twitches and anxiety. The most common unrelated symptoms included sleepiness and neck pain. There were initial transient reports of mild neck pain, scalp tingling and headache that were extinguished upon follow-up. No new symptoms were reported upon follow up out to 1 month.Conclusions(s)To date, in the literature and including this report, no serious adverse events have been reported as a result of low intensity tFUS for human neuromodulation. Here, we report new data on minor transient events. As currently employed with the parameters used in the studies in this report, tFUS looks to be a safe form of transient neuromodulation in humans.

scholarly journals Modulation of Cerebellar Cortical Plasticity Using Low-Intensity Focused Ultrasound for Poststroke Sensorimotor Function Recovery

2018 ◽  
Vol 32 (9) ◽  
pp. 777-787 ◽  
Author(s):  
Hongchae Baek ◽  
Ki Joo Pahk ◽  
Min-Ju Kim ◽  
Inchan Youn ◽  
Hyungmin Kim
Keyword(s):  
Brain Stimulation ◽  
Focused Ultrasound ◽  
Cortical Plasticity ◽  
Cortical Excitability ◽  
Motor Evoked Potentials ◽  
Brain Regions ◽  
Adaptive Plasticity ◽  
Alternative Pathways ◽  
Low Intensity

Background. Stroke affects widespread brain regions through interhemispheric connections by influencing bilateral motor activity. Several noninvasive brain stimulation techniques have proved their capacity to compensate the functional loss by manipulating the neural activity of alternative pathways. Over the past few decades, brain stimulation therapies have been tailored within the theoretical framework of modulation of cortical excitability to enhance adaptive plasticity after stroke. Objective. However, considering the vast difference between animal and human cerebral cortical structures, it is important to approach specific neuronal target starting from the higher order brain structure for human translation. The present study focuses on stimulating the lateral cerebellar nucleus (LCN), which sends major cerebellar output to extensive cortical regions. Methods. In this study, in vivo stroke mouse LCN was exposed to low-intensity focused ultrasound (LIFU). After the LIFU exposure, animals underwent 4 weeks of rehabilitative training. Results. During the cerebellar LIFU session, motor-evoked potentials (MEPs) were generated in both forelimbs accompanying excitatory sonication parameter. LCN stimulation group on day 1 after stroke significantly enhanced sensorimotor recovery compared with the group without stimulation. The recovery has maintained for a 4-week period in 2 behavior tests. Furthermore, we observed a significantly decreased level of brain edema and tissue swelling in the affected hemisphere 3 days after the stroke. Conclusions. This study provides the first evidence showing that LIFU-induced cerebellar modulation could be an important strategy for poststroke recovery. A longer follow-up study is, however, necessary in order to fully confirm the effects of LIFU on poststroke recovery.

scholarly journals Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0224311 ◽  
Author(s):  
Kyungho Yoon ◽  
Wonhye Lee ◽  
Ji Eun Lee ◽  
Linda Xu ◽  
Phillip Croce ◽  
...  
Keyword(s):  
Brain Stimulation ◽  
Focused Ultrasound ◽  
Ovine Model ◽  
Sonication Parameters ◽  
Transcranial Focused Ultrasound
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