scholarly journals The ability to diagnose autoimmune thyroiditis with an X-ray fluorescence method to determine the level of stable intrathyroid iodine

1999 ◽  
Vol 45 (3) ◽  
pp. 28-30
Author(s):  
I. O. Tomashevsky
Keyword(s):  
Autoimmune Thyroiditis ◽  
Laboratory Data ◽  
Reference Specimen ◽  
Thyroid Status ◽  
Normal Thyroid ◽  
X Ray ◽  
Fluorescent Analysis ◽  
Fluorescent Method ◽  
History Of ◽  
Stable Iodine

The concentration of intrathyroid stable iodine (ISI) is measured using a Russian commercial reference specimen for noninvasive x-ray fluorescent analysis in 74 women with autoimmune thyroiditis (verified cytomorphologically) aged 36-55 years, residents of Moscow, and in 36 women without a history of thyroid diseases, with normal thyroid status confirmed by clinical and laboratory data and /SI level of at least 200 pg/g, which is considered as the critical (control). Noninvasive x-ray fluorescent method for detecting ISI deficiency permits the recognition of autoimmune thyroiditis with sensitivity and accuracy of at least 9% but with low specificity, which recommends it for screening diagnosis.

Differential diagnosis of thyroid diseases by the x-ray fluorescent method

2019 ◽  
Vol 43 (3) ◽  
pp. 38-42
Author(s):  
I. О. Tomashevsky
Keyword(s):  
Autoimmune Thyroiditis ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
Thyroid Diseases ◽  
Benign Tumors ◽  
Commercial Sample ◽  
X Ray ◽  
Thyroid Adenomas ◽  
The Usa ◽  
History Of

Intrathyroid stable iodine (ISI) was measured in 249 women aged 36 to 55 living in Moscow. 179 of these suffered from thyroid tumors and autoimmune thyroiditis and 70 without history of thyroid diseases with normal thyroid status confirmed by clinical laboratory data and ISI values of at least 200 pg/g, considered as the critical, were controls. ISI concentrations were measured using a Russian commercial sample for noninvasive x-ray fluorescent analysis. Using the same device, ISI was measured in thyroid samples with cancer and benign tumors, embedded in paraffin blocks, sent from the USA (n - 47) and Russia (n = 126); in addition, these samples were examined histologically. ISI concentrations were lower in cancer, thyroid adenomas, and autoimmune thyroiditis than in control. An ISI concentration lower than 200 pg/g indicates autoimmune thyroiditis with a probability of 96%. Use of L- thyroxin test increases the probability of the disease recognition to 98%.

scholarly journals VARIANTS OF THYROID GLAND PATHOLOGY IN CHRONIC HEPATITIS C PATIENTS

2017 ◽  
Vol 22 (4) ◽  
pp. 172-177
Author(s):  
Marina A. Nikonorova ◽  
N. S Lubskaya ◽  
E. V Volchkova ◽  
E. A Nemilostiva ◽  
O. I Matros
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Thyroid Gland ◽  
Antiviral Therapy ◽  
Chronic Hepatitis C ◽  
Autoimmune Thyroiditis ◽  
Thyroid Dysfunction ◽  
Thyroid Status ◽  
History Of ◽  
The Relationship

Introduction. HCV is the cause not only of cirrhosis, hepatocellular carcinoma, but also extrahepatic manifestations. Currently, HCV is considered as an independent risk factor for thyroid pathology. In recent years, the level of pathology of the thyroid gland in the Altai Territory has increased by 16.4 times, which determined the purpose of this study: to study the features of the thyroid status in patients with chronic hepatitis C (CHC) in the Altai Territory. Materials and methods. There was executed a prospective, dynamic clinical, laboratory and instrumental examination of 240 CHC patients (47,5% of men and 52,5% of women aged of from 18 to 50 years), 120 of whom had HCV (49,1% of men and 50,9% of women, aged of from 18 to 50 years, mean age: 41,1±9,91 years) who did not receive antiviral therapy (HTV), the pathology of the thyroid gland in them was established for the first time. The study included the assessment of the level of TSH, total and free T3, T4, antibodies to thyreperoxidase (APPO), ultrasound examination of the thyroid gland. The diagnosis of CHC is based on HCV RNA, anti-HCV (core, NS3-5), blood biochemistry, fibrosis level score according to Metavir (elastometry, PBP). Results of the study. In HCV patients there were revealed autoimmune thyroiditis (AIT) (5%), AIT with hypothyroidism (10%), AIT with latent hypothyroidism (8,3%), latent hypothyroidism (10%), hypothyroidism (16,6%), euthyroidism (49,1%) and thyrotoxicosis in only 1 patient. Variants of thyroid dysfunction were presented in the form of euthyroidism (60%), hypothyroidism (20%), hyperthyroidism (10%) and autoimmune thyroiditis (10%). The relationship between the development of the thyroid dysfunction (TD) and the history of the history of HCV infection has been established. Discussion and conclusions. CHC patients were more likely to have a history of euthyroidism and hypothyroidism. The relationship between TD and the duration of HCV infection can be regarded as its extrahepatic manifestation, and not as comorbid conditions. Thorough examination of the thyroid status it makes possible to identify TD people, which can be reflected in the choice of antiviral therapy and will determine the prognosis of the development of side effects.

scholarly journals Diagnostic possibilities for autoimmune thyroiditis using non-invasive determination of intrathyroid iodine concentration in children

2019 ◽  
Vol 45 (1) ◽  
pp. 21-23
Author(s):  
I. A. Vasilevskaya ◽  
I. O. Tomashevsky
Keyword(s):  
Enzyme Immunoassay ◽  
Case History ◽  
Autoimmune Thyroiditis ◽  
Microsomal Fraction ◽  
Iodine Concentration ◽  
Threshold Level ◽  
X Ray ◽  
Non Invasive ◽  
Stable Iodine

Sixty-seven children (55 girls and 12 boys) aged 5-16 years were examined. Autoimmune thyroiditis (AT) was diagnosed in 28 and diffuse nontoxic goiter (DNG) in 39. The diseases were diagnosed on the basis of case history, results of examination and palpation of the thyroid, ultrasonic findings, presence of antibodies to thyroglobulin (in AT) or their absence (in DNG), and the microsomal fraction detected by enzyme immunoassay using Boehringer Mannheim kits. AT diagnosis was confirmed cytomorphologically in all patients. Intrathyroid stable iodine (ISI) was measured by a Russian noninvasive x-ray fluorescent analyzer. ISI concentration was notably decreased in children with autoimmune thyroiditis confirmed by cytomorphological methods: below the threshold level of the method in 46%) cases and 120±10 mcg/g in 54%). This confirms a high informative value of the proposed method in this disease. Measurements of ISI in children with enlarged thyroid helps differentiate the hypertrophic form of AT from DNG: ISI concentration under 200 mcg/g is characteristic of AT, while in DNG the concentration of ISI in Moscow children is 500±40 mcg/g (M±m).

scholarly journals THYROID STATUS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS

2021 ◽  
Vol 06 (01) ◽  
pp. 71-72
Author(s):  
Zhanar Nurgaliyeva Zhanar Nurgaliyeva ◽  
Araily Manasbaeva Araily Manasbaeva ◽  
Sakhipzhamal Sabirova Sakhipzhamal Sabirova ◽  
Saiyara Nadyrova Saiyara Nadyrova ◽  
Alfira Muratkhan Alfira Muratkhan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Hormone ◽  
Autoimmune Thyroiditis ◽  
Laboratory Data ◽  
Thyroid Status ◽  
Free T4 ◽  
Hormone Levels ◽  
Functional Changes ◽  
Free T3 ◽  
Thyroid Hormone Levels

The mutually aggravating effect of comorbid diseases of diabetes mellitus (DM) and autoimmune thyroiditis (AIT) is of scientific interest to researchers. Timely assessment of the thyroid status in children with DM and correction of thyroid pathology (TP) will improve metabolic control in these patients. Аmong 972 children with DM, 478 (49.2%) were assessed for thyroid status. It is noted that every year the determination of thyroid hormone levels in children increased from 7.6% (in 2014) to 92.1% (in 2019). Among 478 examined children, 319 (66.7%) had significantly revealed thyroid dysfunction. In the structure of thyroid pathologies, the frequency of hypothyroidism was 12.5% (in 11.3% - subclinical form), hyperthyroidism - 4%. functional changes in the concentration of thyroid hormones as Euthyroid sick syndrome were observed in 23.8%. The most common type of dysfunction was an isolated increase in free T3 (isolated T3 toxicosis) – in 43.3% of cases. In 2 cases out of 18 (0.6%), a complete picture of AIT was presented, and in the remaining 16 (5.1%), signs of AIT were observed only on ultrasound of the thyroid gland, and were not confirmed by the concentrations of anti-TPO Ab, anti-TG Ab. In 47 (14.7%) children, laboratory data on thyroid hormone levels showed elevated values of TSH, free T3, free T4. Keywords: children, diabetes mellitus, thyroid status, autoimmune thyroiditis

scholarly journals Intrathyroid stable iodine level and thyroid tumors

1996 ◽  
Vol 42 (3) ◽  
pp. 6-8
Author(s):  
I. O. Tomashevsky ◽  
Ye. A. Troshina ◽  
G. A. Gerasimov ◽  
M. E. Bronstein ◽  
S. Yu. Serpukhovitin ◽  
...  
Keyword(s):  
Clinical Studies ◽  
Thyroid Nodules ◽  
Iodine Concentration ◽  
Thyroid Tumors ◽  
X Ray ◽  
Fluorescent Analysis ◽  
Iodine Level ◽  
The Usa ◽  
Stable Iodine

Intrathyroid iodine level was measured in 126 patients with different thyroid tumours in Russia and in 37 ones in the USA by X-ray fluorescent analysis in vitro. A decrease of intrathyroid iodine concentration was found to be associated with a stepwise loss of differentiation of thyroid tumours. In colloid goitre tissue from Russia, the intrathyroid level of iodine was increased. It was markedly increased in microfollicular adenomas and colloid goitre tissue from American patients, which fact may reflect a higher iodine supply in the USA. X-Ray fluorescent analysis together with clinical studies may be used in preoperative examinations of patients with thyroid nodules.

Budd-Chiari syndrome due to segmental obstruction of the inferior vena cava successfully managed with endovascular stenting

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 22-26
Author(s):  
Uyen Vo ◽  
Duc Quach ◽  
Luan Dang ◽  
Thao Luu ◽  
Luan Nguyen
Keyword(s):  
Inferior Vena Cava ◽  
Inferior Vena ◽  
Laboratory Data ◽  
Transaminase Level ◽  
Vena Cava ◽  
Budd Chiari Syndrome ◽  
Endovascular Stenting ◽  
Massive Ascites ◽  
Chiari Syndrome ◽  
History Of

Budd–Chiari syndrome (BCS), a rare and life-threatening disorder due to hepatic venous outflow obstruction, is occasionally associated with hypoproteinemia. We herein report the first case of BCS with segmental obstruction of the intrahepatic portion of inferior vena cava (IVC) and hepatic veins (HVs) successfully treated by endovascular stenting in Vietnam. A 32-year-old female patient presented with a 2-month history of massive ascites and leg swelling. She refused history of oral contraceptives use. Hepatosplenomegaly without tenderness was noted. Laboratory data showed polycythemia, mild hypoalbuminemia and hypoproteinemia, slightly high total bilirubin and normal transaminase level. The serum ascites albumin gradient was 1.9 g/dL and ascitic protein level was 1.1 g/dL. The other data were normal. BCS was suspected because of the discrepancy between mild liver failure and massive ascites; and the presence of hepatosplenomegaly and polycythemia. On abdominal magnetic resonance imaging, the segmental obstruction of three HVs and IVC was 2-3 cm long without thrombus. Cavogram revealed the severe segmental stenosis of intrahepatic portion of IVC with no visualized HV and extensive collateral veins. A Protégé stent was deployed to IVC. Leg swelling and ascites were completely resolved within 3 days after stenting. During 1-year follow-up, edema was not recurred and repeated laboratory results were all normal.

Lingual Dystonia Treated with Botulinum Toxin - A Case Report

1970 ◽  
Vol 24 (2) ◽  
pp. 75-78
Author(s):  
MA Hayee ◽  
QD Mohammad ◽  
H Rahman ◽  
M Hakim ◽  
SM Kibria
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Botulinum Toxin Type A ◽  
Botulinum Toxin Type ◽  
X Ray ◽  
Medical College ◽  
Lingual Dystonia ◽  
History Of ◽  
Chest X Ray

A 42-year-old female presented in Neurology Department of Sir Salimullah Medical College with gradually worsening difficulty in talking and eating for the last four months. Examination revealed dystonic tongue, macerated lips due to continuous drooling of saliva and aspirated lungs. She had no history of taking antiparkinsonian, neuroleptics or any other drugs causing dystonia. Chest X-ray revealed aspiration pneumonia corrected later by antibiotics. She was treated with botulinum toxin type-A. Twenty units of toxin was injected in six sites of the tongue. The dystonic tongue became normal by 24 hours. Subsequent 16 weeks follow up showed very good result and the patient now can talk and eat normally. (J Bangladesh Coll Phys Surg 2006; 24: 75-78)

Highlights in the history of X-ray topography1

1995 ◽  
Vol 210 (6) ◽  
Author(s):  
A. R. Lang
Keyword(s):  
Magnetic Domain ◽  
Diffraction Theory ◽  
Dislocation Loops ◽  
X Ray Diffraction ◽  
X Ray ◽  
Domain Structures ◽  
Structure Factors ◽  
History Of ◽  
Dislocation Sources ◽  
Non Destructive

AbstractX-ray topography provides a non-destructive method of mapping point-by-point variations in orientation and reflecting power within crystals. The discovery, made by several workers independently, that in nearly perfect crystals it was possible to detect individual dislocations by X-ray diffraction contrast started an epoch of rapid exploitation of X-ray topography as a new, general method for assessing crystal perfection. Another discovery, that of X-ray Pendellösung, led to important theoretical developments in X-ray diffraction theory and to a new and precise method for measuring structure factors on an absolute scale. Other highlights picked out for mention are studies of Frank-Read dislocation sources, the discovery of long dislocation helices and lines of coaxial dislocation loops in aluminium, of internal magnetic domain structures in Fe-3 wt.% Si, and of stacking faults in silicon and natural diamonds.

Glucose Levels and Outcome After Primary Intraventricular Hemorrhage

2019 ◽  
Vol 16 (1) ◽  
pp. 40-46
Author(s):  
Rui Guo ◽  
Ruiqi Chen ◽  
Chao You ◽  
Lu Ma ◽  
Hao Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Incidence Rate ◽  
Glucose Level ◽  
Intraventricular Hemorrhage ◽  
Laboratory Data ◽  
History Of ◽  
Poor Outcomes ◽  
The Impact

Background and Purpose: Hyperglycemia is reported to be associated with poor outcome in patients with spontaneous Intracerebral Hemorrhage (ICH), but the association between blood glucose level and outcomes in Primary Intraventricular Hemorrhage (PIVH) remains unclear. We sought to identify the parameters associated with admission hyperglycemia and analyze the impact of hyperglycemia on clinical outcome in patients with PIVH. Methods: Patients admitted to Department of Neurosurgery, West China Hospital with PIVH between 2010 and 2016 were retrospectively included in our study. Clinical, radiographic, and laboratory data were collected. Univariate and multivariate logistic regression analyses were used to identify independent predictors of poor outcomes. Results: One hundred and seventy patients were included in the analysis. Mean admission blood glucose level was 7.78±2.73 mmol/L and 10 patients (5.9%) had a history of diabetes mellitus. History of diabetes mellitus (P = 0.01; Odds Ratio [OR], 9.10; 95% Confidence Interval [CI], 1.64 to 50.54) was independent predictor of admission critical hyperglycemia defined at 8.17 mmol/L. Patients with admission critical hyperglycemia poorer outcome at discharge (P < 0.001) and 90 days (P < 0.001). After adjustment, admission blood glucose was significantly associated with discharge (P = 0.01; OR, 1.30; 95% CI, 1.06 to 1.59) and 90-day poor outcomes (P = 0.03; OR, 1.27; 95% CI, 1.03 to 1.58), as well as mortality at 90 days (P = 0.005; OR, 1.41; 95% CI, 1.11 to 1.78). In addition, admission critical hyperglycemia showed significantly increased the incidence rate of pneumonia in PIVH (P = 0.02; OR, 6.04; 95% CI 1.27 to 28.80) even after adjusting for the confounders. Conclusion: Admission blood glucose after PIVH is associated with discharge and 90-day poor outcomes, as well as mortality at 90 days. Admission hyperglycemia significantly increases the incidence rate of pneumonia in PIVH.

Syphilis among men who have sex with men attending a large HIV clinic in Trinidad

2021 ◽  
pp. 095646242199719
Author(s):  
Robert Jeffrey Edwards ◽  
Isshad John ◽  
Selena Todd ◽  
Leon-Omari Lavia ◽  
David Musa ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Chart Review ◽  
Laboratory Data ◽  
Previous History ◽  
History Of ◽  
Review Study ◽  
Sex With Men ◽  
Associated Risk Factors ◽  
Living With Hiv ◽  
Age Range

A chart review study was conducted to determine the prevalence of syphilis and explore the associated risk factors among men who have sex with men (MSM) who attended a large HIV clinic in Trinidad during the period January–December 2019. Patients were routinely screened for syphilis annually, and demographic, clinical, and laboratory data were extracted from the medical records. Descriptive and bivariate analyses were performed, and factors significantly associated with a syphilis diagnosis were assessed using multivariate logistic regression. During the period, 218 MSM were seen, age range 19–67 years, and median age 34.0 years. The prevalence of syphilis was 41.3% (90/218), and 71.1% (64//90) of these infections were asymptomatic. Multivariate analysis using logistic regression showed that MSM living with HIV in the 30–34 years old-age group (OR, 4.32; 95% CI, 1.04–18.02), and those with a previous history of treated syphilis (OR, 10.18; 95% CI, 4.60–22.53) were more likely to be diagnosed with syphilis. The prevalence of syphilis is high among MSM attending the HIV clinic in Trinidad, and most of these infections were asymptomatic; hence, targeted and sustained interventions to reduce syphilis transmission are urgently required. Repeat episodes of syphilis may play a role in the transmission dynamics of syphilis in MSM.

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