Differential diagnosis of thyroid diseases by the x-ray fluorescent method

2019 ◽  
Vol 43 (3) ◽  
pp. 38-42
Author(s):  
I. О. Tomashevsky
Keyword(s):  
Autoimmune Thyroiditis ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
Thyroid Diseases ◽  
Benign Tumors ◽  
Commercial Sample ◽  
X Ray ◽  
Thyroid Adenomas ◽  
The Usa ◽  
History Of

Intrathyroid stable iodine (ISI) was measured in 249 women aged 36 to 55 living in Moscow. 179 of these suffered from thyroid tumors and autoimmune thyroiditis and 70 without history of thyroid diseases with normal thyroid status confirmed by clinical laboratory data and ISI values of at least 200 pg/g, considered as the critical, were controls. ISI concentrations were measured using a Russian commercial sample for noninvasive x-ray fluorescent analysis. Using the same device, ISI was measured in thyroid samples with cancer and benign tumors, embedded in paraffin blocks, sent from the USA (n - 47) and Russia (n = 126); in addition, these samples were examined histologically. ISI concentrations were lower in cancer, thyroid adenomas, and autoimmune thyroiditis than in control. An ISI concentration lower than 200 pg/g indicates autoimmune thyroiditis with a probability of 96%. Use of L- thyroxin test increases the probability of the disease recognition to 98%.

scholarly journals The ability to diagnose autoimmune thyroiditis with an X-ray fluorescence method to determine the level of stable intrathyroid iodine

1999 ◽  
Vol 45 (3) ◽  
pp. 28-30
Author(s):  
I. O. Tomashevsky
Keyword(s):  
Autoimmune Thyroiditis ◽  
Laboratory Data ◽  
Reference Specimen ◽  
Thyroid Status ◽  
Normal Thyroid ◽  
X Ray ◽  
Fluorescent Analysis ◽  
Fluorescent Method ◽  
History Of ◽  
Stable Iodine

The concentration of intrathyroid stable iodine (ISI) is measured using a Russian commercial reference specimen for noninvasive x-ray fluorescent analysis in 74 women with autoimmune thyroiditis (verified cytomorphologically) aged 36-55 years, residents of Moscow, and in 36 women without a history of thyroid diseases, with normal thyroid status confirmed by clinical and laboratory data and /SI level of at least 200 pg/g, which is considered as the critical (control). Noninvasive x-ray fluorescent method for detecting ISI deficiency permits the recognition of autoimmune thyroiditis with sensitivity and accuracy of at least 9% but with low specificity, which recommends it for screening diagnosis.

scholarly journals Clinical Characteristics, Dynamic Profile of Radiology and Laboratory Findings in Coronavirus Disease 2019

2020 ◽  
Author(s):  
ailing liu ◽  
Jing Zhang ◽  
Wei Qiao ◽  
Wei Zang ◽  
Yingying Zhang ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Laboratory Data ◽  
Oxygenation Index ◽  
Laboratory Findings ◽  
Single Centre Study ◽  
History Of ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Dynamic Profile

Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, more and more data from different area and different stages of disease have been needed.Methods In this retrospective, single-centre study, we included all 38 confirmed cases of Covid-19 in Weihai from Jan 24 to Feb 24, 2020. Patients were divided into group A by normal Oxygenation Index (OI), group B by abnormal OI (less than 400 mmHg).The dynamic changes in clinical laboratory parameters were tracked from day 1 to day 32 after the onset of the disease at 4-day intervals. Cases were analyzed for clinical, radiological features and laboratory data. Outcomes were followed up until Feb 24, 2020.Results 38 patients with Covid-19 were included in this study, 68.42% patients were family clustered, and 97.37% patients had a history of exposure. The mean days between exposure and onset were about 5 days. Most patients were men, mean age was 43 years, 52.6% patients had chronic diseases. Most patients had fever or cough, about a third of patients had expectoration or fatigue, and 5 (13.16%) patients had shortness of breath.

scholarly journals Evaluation of Trace Elements in Thyroid Adenomas Using Energy Dispersive X-Ray Fluorescent Analysis

2021 ◽  
pp. 1-7
Author(s):  
Vladimir Zaichick ◽  
Keyword(s):  
Trace Elements ◽  
Exploratory Study ◽  
Thyroid Tissue ◽  
Energy Dispersive ◽  
Benign Tumors ◽  
Tissue Samples ◽  
X Ray ◽  
Fluorescent Analysis ◽  
Thyroid Adenomas

Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of trace elements (TE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to examine the content of bromine (Br), cooper (Cu), iron (Fe), rubidium (Rb), strontium (Sr), and zinc (Zn) in the normal and in adenomatous thyroid. Thyroid tissue levels of six TE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using 109Cd radionuclide-induced energy-dispersive X-ray fluorescent analysis Tissue samples were divided into two portions. One was used for morphological study while the other was intended for TE analysis. It was found that contents of Br and Cu were significantly higher (25.8 and 4.16 times, respectively) and content of Sr were significantly lower (39%) in adenomatous thyroid in comparison with normal level. There are considerable changes in TE contents in the adenomatous thyroid.

scholarly journals FRI0350 FACTORS ASSOCIATED WITH PERIPHERAL EROSIVE RADIOGRAPHIC DISEASE IN A CONSECUTIVE SERIES OF 794 PSA PATIENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 770-771
Author(s):  
M. G. Catanoso ◽  
P. Macchioni ◽  
A. Marchesoni ◽  
S. D’angelo ◽  
R. Ramonda ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Tertiary Care ◽  
Laboratory Data ◽  
Diagnostic Delay ◽  
Disease Diagnosis ◽  
Biological Agents ◽  
Consecutive Series ◽  
Imaging Data ◽  
Erosive Disease ◽  
History Of

Background:Few studies have examined the correlation between clinical demographic and laboratory parameters with peripherical radiological erosive disease in PsA pts.Objectives:To examine the association between clinical, demographical and laboratory data and the presence of radiographic erosions (RE) in the peripheral joints of psoriatic arthritis (PsA) pts.Methods:A cross-sectional study was conducted in consecutive patients with PsA afferring 7 rheumatological italian tertiary care centers. Demographical, clinical, laboratory and imaging data were collected according to a standardized protocol. A patient was considered as affected by erosive disease (ED) if at least one joint presented radiographic erosions at hand and/or feet rx examination. Patients with ED at early rx examination (before 5 y from disease diagnosis) were considered as early ED (EED) pts and pts without ED at 6 y or more rx examination from disease diagnosis were considered as not EED (NEED).The association between the presence of joint erosions and demographical, clinical and laboratory data was assessed using logistic regression analysis. The results were expressed in terms odds ratios (OR), and 95% confidence intervals (CI).Results:Rx hand and feet examination were available for analysis in 492/794 (39.9 % females, mean age 53.3 ± 13.2 y, mean PsA duration 16.9 ± 16.8 y, ED 171 pts). 48 pts had EED and 133 pts had NEED. At univariate analyses factors significantly associated with EED (p < 0.20) were PsA duration (OR=0.979,95%CI 0.953-1.006, p = 0.119), diagnostic delay (OR=1.077, 95%CI 1.018-1.138, p = 0.009), history of peripheral enthesitis (OR=2.308,95%CI 0.904-5.888, p= 0.080), hypertrigliceridemia (OR=2.756,95%CI 0.997-7.618, p = 0.0.051), hypercholesterolemia (OR=1.687, 95%CI 0.777-3.661, p = 0.186), hyperuricemia (OR=0.450, 95%CI 0.174-1.166, p = 0.10), use of biological agents (OR=1.712, 95%CI 0.873-3.355, p=0.118). Factors significantly associated with EED at multivariate regression analyses were diagnostic delay (OR = 1.11, 95% CI: 1.01, 1.22), history of enthesitis (OR = 3.15, 95% CI: 1.23, 8.22), use of therapy with biological agents (OR = 3.60, 95% CI: 1.31, 9.85) with protective effect of hyperuricemia (OR = 0.25, 95% CI: 0.07, 0.90).Conclusion:The presence of EED in a group of consecutive PsA patients is correlated to diagnostic delay and history of enthesitis. Longitudinal study may confirm these associations.Disclosure of Interests:Maria Grazia Catanoso: None declared, Pierluigi Macchioni: None declared, Antonio Marchesoni Speakers bureau: Abbvie, Pfizer, UCB, Novartis, Celgene, Eli Lilly, Salvatore D’Angelo Speakers bureau: AbbVie, Biogen, BMS, Celgene, Janssen, Lilly, MSD, Novartis, Pfizer, Sanofi, and UCB, Roberta Ramonda Speakers bureau: Novartis, Celgene, Janssen, Pfizer, Abbvie, Lilly, Alberto Cauli: None declared, fabio perrotta: None declared, Roberto Bortolotti: None declared, mariana lofrano: None declared, laura rotunno: None declared, maria grazia lorenzin: None declared, Guido Valesini: None declared, giovanni mathieu: None declared, Giuseppe Paolazzi: None declared, Carlo Salvarani Grant/research support from: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis, Consultant of: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis

scholarly journals CLINICAL AND LABORATORY ASPECTS OF ACUTE OBSTRUCTIVE BRONCHITIS IN CHILDREN INFECTED WITH MYCOPLASMA PNEUMONIAE

2020 ◽  
Vol 73 (6) ◽  
pp. 1229-1233
Author(s):  
Svitlana H. Usenko ◽  
Zalina V. Yeloeva ◽  
Maryna S. Diachenko ◽  
Serhiy A. Usenko
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Medical Records ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
Statistical Processing ◽  
Acute Bronchitis ◽  
Older Children ◽  
Systematic Analysis ◽  
History Of ◽  
Intracellular Infections

The aim of the work is to improve the prognosis of acute bronchitis on the basis of the study of etiology, clinical anamnestic and laboratory-instrumental features of acute bronchitis in children infected with Mycoplasma pneumoniae. Materials and methods: Medical records of inpatients, data from laboratory and clinical examinations, orders from the Ministry of Health of Ukraine. Statistical processing of the obtained results was carried out with the calculation of parametric and non-parametric criteria. The study included 72 patients with acute obstructive bronchitis, infected with Mycoplasma pneumoniae and patients not infected with intracellular pathogens who were hospitalized under the conditions of pediatric ward of children of younger and older children of the National Children’s Clinical Hospital №24. Results: Found that infected with mycoplasma compared with uninfected intracellular infection, more characteristic course of acute obstructive bronchitis on the background of febrile temperature with its duration of more than 4 days, the presence of midbubble and single dry or wet rales, as well as. In general, in patients infected with mycoplasma, compared with patients infected with chlamydia, there is a higher functional stress of immunity with the phenomena of exhaustion. Conclusions: Attention is drawn to the fact that clinical, laboratory data and immunological examinations with the use of systematic analysis make it possible to predict the consequences in the history of children with intracellular infections of various somatic pathologies. In doing so, multivariate and correlation analyzes make it possible to develop new diagnostic criteria.

Prevalence and clinical characteristics of patients with biologically false-positive reactions with serological syphilis testing in contemporary practice: 10-year experience at a tertiary academic hospital

2020 ◽  
pp. sextrans-2020-054628
Author(s):  
Yuri Ishihara ◽  
Koh Okamoto ◽  
Hironori Shimosaka ◽  
Yoshikazu Ono ◽  
Yoshiaki Kanno ◽  
...  
Keyword(s):  
False Positive ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Serological Test ◽  
Laboratory Data ◽  
Test Results ◽  
Academic Hospital ◽  
History Of ◽  
Low Incidence ◽  
Contemporary Practice

ObjectivesBiologically false positive (BFP) reactions are well described in early literature. However, only a few recent reports described the incidence and clinical characteristics of patients with BFP reactions. We reviewed the serological test results of patients tested for syphilis in our hospital in the past decade and described the clinical characteristics of patients with BFP reactions.MethodsThis is a retrospective study of patients tested for syphilis in a tertiary academic hospital. All serological results were retrieved from the clinical laboratory database. We calculated the incidence of BFP reactions. Clinical characteristics and laboratory data of patients with BFP reactions were reviewed manually.ResultsAmong 94 462 subjects, 588 patients had BFP reactions (0.62%). Most BFP reactions were observed in patients aged over 60 years, with a history of malignancy and autoimmune diseases. Eighty-five per cent of patients had low rapid plasma reagin (RPR) titre (≤1:4), but two patients had extremely high RPR titre (≥1:256). BFP reactions were more likely to persist beyond 6 months among patients with RPR titre of ≥1:8. There was no statistically significant correlation between RPR titre and total protein albumin gap, surrogate of immunoglobulin levels among patients with BFP reactions.ConclusionThere was a low incidence of BFP reactions in the last decade. A minority of BFP reactions had high non-treponemal antibody titre and persisted longer than 6 months. In the era of re-emergence of syphilis, this information could help clinicians interpret the results of well-established diagnostic tests for syphilis.

scholarly journals Clinical, laboratory and X-ray findings of drowning and near-drowning in the Gulf of Aqaba

1999 ◽  
Vol 5 (4) ◽  
pp. 706-709
Author(s):  
A. Al Talafieh ◽  
R. Al Majali ◽  
G. Al Dehayat
Keyword(s):  
Clinical Laboratory ◽  
Laboratory Data ◽  
Respiratory Acidosis ◽  
Blood Gases ◽  
Gas Analysis ◽  
Gulf Of Aqaba ◽  
International Studies ◽  
Arterial Blood Gas ◽  
X Ray ◽  
Arterial Blood

Clinical, laboratory and X-ray findings in 34 victims of submersion are presented. Five people died and 29 survived [age range 12-60 years]. Severe hypoxia was found in all patients [mean PO2 of 58 mmHg with some oxygen support]. Arterial blood gas analysis showed significant metabolic acidosis in 19 patients and significant respiratory acidosis in 15 patients. Pulmonary oedema was the most common X-ray finding. Fourteen patients were put on mechanical ventilation on the basis of their clinical picture and blood gases analysis. Clinical and laboratory data are very similar to those reported in international studies

scholarly journals SREAT presenting as decades of intractable seizures and isolated delusional episodes with clinical, laboratory, and EEG confirmation of treatment response

2019 ◽  
Vol 7 ◽  
pp. 2050313X1985005
Author(s):  
Elysia Tjong ◽  
Rachael Gardner ◽  
Yen-Yi Peng
Keyword(s):  
Epilepsy Surgery ◽  
Autoimmune Thyroiditis ◽  
Clinical Laboratory ◽  
Intractable Epilepsy ◽  
Temporal Lobectomy ◽  
Intractable Seizures ◽  
Autoimmune Epilepsy ◽  
History Of ◽  
Quantitative Electroencephalogram

We report a case of a 60-year-old woman with a history of intractable seizures and isolated delusional psychosis who was later diagnosed with steroid-responsive encephalopathy associated with autoimmune thyroiditis. The patient underwent right temporal lobectomy (epilepsy surgery) 15 years before coming to this clinic, but continued to have focal seizures, resulting in frequent emergency room visits thereafter. After admission for intensive inpatient video electroencephalogram monitoring and subsequent 7 months of close follow-up, both the electroencephalogram abnormalities and isolated delusional psychosis were found to be responsive to immunotherapy. This suggests that her epilepsy may be autoimmune in nature. Steroid-responsive encephalopathy associated with autoimmune thyroiditis was diagnosed after 26 years since the onset of seizures. Performing invasive epilepsy surgery in patients with autoimmune epilepsy cannot reverse the inflammatory process; therefore, it is reasonable to test for autoimmune etiologies before excision surgery on patients with medically intractable epilepsy. This case demonstrates the clinical use of quantitative electroencephalogram in assisting with the diagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis and supports that it is a spectrum disorder with protean manifestations.

The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events

2010 ◽  
Vol 14 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Toyoki Maeda ◽  
Jun-Ichi Oyama ◽  
Yoshihiro Higuchi ◽  
Masamichi Koyanagi ◽  
Makoto Sasaki ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Clinical Laboratory ◽  
Laboratory Data ◽  
Clinical History ◽  
Vascular Events ◽  
History Of ◽  
Male Patients

scholarly journals Bartonella henselaeInfection: An Uncommon Mimicker of Autoimmune Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Despoina N. Maritsi ◽  
Diagoras Zarganis ◽  
Zoi Metaxa ◽  
Georgia Papaioannou ◽  
George Vartzelis
Keyword(s):  
Clinical Laboratory ◽  
Imaging Features ◽  
Immunocompetent Host ◽  
X Ray ◽  
Systemic Involvement ◽  
Night Sweats ◽  
History Of ◽  
Chest X Ray ◽  
Systemic Symptoms ◽  
Immunocompetent Patients

We present a case of a seven-year-old immunocompetent female patient who developed systemic symptoms mimicking an autoimmune rather than an infectious disease. The patient presented with rash, biquotidian fever, night sweats, and arthralgias. There was no antecedent history of cat contact. Investigations showed increased inflammatory markers, leukocytosis, thrombocytosis, hypercalcemia, and raised angiotensin-converting enzyme. Interferon-gamma releasing assay for tuberculosis infection was negative. Abdominal imaging demonstrated multifocal lesions of the liver and spleen (later proved to be granulomata), chest X-ray showed enlarged hilar lymph nodes, and ophthalmology review revealed uveitis. Clinical, laboratory, and imaging features pointed towards sarcoidosis. Subsequently, raised titers (IgM 1 : 32, IgG 1 : 256) againstBartonellaconfirmed the diagnosis ofB. henselaeinfection. She was treated with gentamycin followed by ciprofloxacin; repeat investigations showed complete resolution of findings. The presence of hepatic and splenic lesions in children with bartonellosis is well documented. Our case, however, exhibited certain unusual findings such as the coexistence of acute ocular and systemic involvement in an immunocompetent host. Serological testing is an inexpensive and effective way to diagnose bartonellosis in immunocompetent patients; we suggest that bartonella serology is included in the baseline tests performed on children with prolonged fever even in the absence of contact with cats in countries where bartonellosis is prevalent.

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