TREATMENT EFFECTS OF VORTIOXETINE ON COGNITIVE FUNCTIONS IN MILD ALZHEIMER’S DISEASE PATIENTS WITH DEPRESSIVE SYMPTOMS: A 12 MONTH, OPEN-LABEL, OBSERVATIONAL STUDY

2019 ◽  
pp. 1-6 ◽  
Author(s):  
E. Cumbo ◽  
S. Cumbo ◽  
S. Torregrossa ◽  
D. Migliore
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Cognitive Functions ◽  
Digit Span ◽  
Control Group ◽  
Cognitive Tests ◽  
Open Label ◽  
Parallel Group ◽  
Study Setting

BACKGROUND/OBJECTIVES:depressive symptoms are common in Alzheimer’s disease(AD). Aim of the study was to investigate the efficacy of vortioxetine compared with other conventional antidepressants on cognitive functions in AD patients with depressive symptoms. DESIGN: Prospective, randomized, 12 month, parallel-group study. SETTING: All participants were evaluated on-site at Neurodegenerative Disorders Unit, ASP2 Caltanissetta(Italy). PARTICIPANTS: 108(71 female, 37 male) AD patients with depression(mean age 76.7± 4.3). INTERVENTION: Randomized subjects received vortioxetine, 15 mg/day(n=36) or other common antidepressants(n=72). MEASURES:primary outcome was change from baseline in the MMSE; secondary outcomes were change in Attentive Matrices, Raven Coloured Progressive Matrices, Digit Span, HAM-D and Cornell scale. RESULTS: Statistically significant improvement vs. controls was observed for vortioxetine on most of the cognitive tests and showed significantly baseline-to-endpoint reduction in both HAM-D and Cornell total scores.The most commonly reported adverse events were nausea and headache for votioxetine; nausea in the control group. CONCLUSIONS: Vortioxetine had a beneficial effect on cognition and mood in elderly AD patients and was safe and well tolerated.

Acute Exercise and Cognitive Function in Alzheimer’s Disease

2021 ◽  
pp. 1-12
Author(s):  
Ines Ben Ayed ◽  
Naomie Castor-Guyonvarch ◽  
Souad Amimour ◽  
Salma Naija ◽  
Chirine Aouichaoui ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Functions ◽  
Digit Span ◽  
Moderate Intensity ◽  
Current Evidence ◽  
Control Group ◽  
Maximal Heart Rate ◽  
Tower Of Hanoi ◽  
The Impact

Background: Many studies have shown the impact of acute aerobic exercises (AAE) on cognition in healthy adults or at a pre-dementia stage. Few studies, however, have explored the positive effects of AAE in moderate Alzheimer’s disease (ADM) patients. Objective: Evaluating the effect of AAE on cognitive functions in ADM patients. Methods: Overall, 79 (age: 69.62±0.99) ADM patients were recruited. Participants were divided into three groups according to the task: aerobic exercises done alone or combined with cognitive games presented on a screen, and a control group who performed a reading task. The aerobic exercise protocol consisted of a 20-min cycling exercise of moderate intensity, corresponding to 60%of the individual target maximal heart rate recorded in a 6-minute walking test. The participants’ cognition was monitored before and after the intervention using the Tower of Hanoi, Digit Span, and Stroop tasks. Results: After the exercise, the participants’ attention in both the physical and combined groups improved for the Stroop, the forward and backward Digit Span tasks, as well as the time taken to solve the Tower of Hanoi, although no significant differences were found in the number of moves taken in the latter. By contrast, the control group did not show any significant improvement for most of the cognitive tasks after the reading session. Conclusion: Current evidence suggests that AAE may help to improve cognitive functions in ADM patients. This improvement is enhanced when the exercise is combined with cognitive games. Safe and progressive types of exercises should be promoted among ADM patients.

scholarly journals Effect of cortisol levels on working memory performance in elderly subjects with Alzheimer's disease

2008 ◽  
Vol 66 (3b) ◽  
pp. 619-624 ◽  
Author(s):  
Juliana Nery de Souza-Talarico ◽  
Paulo Caramelli ◽  
Ricardo Nitrini ◽  
Eliane Corrêa Chaves
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Working Memory ◽  
Digit Span ◽  
Memory Performance ◽  
Elderly Subjects ◽  
Control Group ◽  
Acute Administration ◽  
Healthy Elderly ◽  
Cortisol Levels

BACKGROUND: Subjects with Alzheimer's disease (AD) have elevated cortisol levels as a result of hypothalamic-pituitary-adrenal (HPA) axis dysfunction. Acute administration of hydrocortisone has been associated with working memory (WM) performance in young adults. OBJECTIVE: To investigate whether cortisol levels are associated with WM performance in subjects with AD. METHOD: Eighty subjects were included, comprising 40 patients with mild AD and 40 healthy elderly controls. WM was assessed using the Digit Span Backward test (DSB). Saliva samples were collected to determine cortisol levels. RESULTS: AD subjects had poorer performance on the DSB than controls (p=0.002) and also presented higher levels of cortisol than control group (p=0.04). No significant correlation was observed between the DSB and cortisol levels in both groups (r= -0.29). CONCLUSION: In this study, elevated cortisol levels were not associated with poorer WM performance in patients with AD or in healthy elderly subjects.

COMPARATIVE ANALYSIS OF UNSATURATED INDICATORS FATTY ACIDS IN ELDERLY PATIENTS IN INITIAL STAGES OF ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA

2020 ◽  
pp. 265-272
Author(s):  
Е. Е. Дубинина ◽  
Л. В. Щедрина ◽  
К. В. Ющин ◽  
Е. В. Светкина ◽  
Н. М. Залуцкая ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Arachidonic Acid ◽  
Comparative Analysis ◽  
Polyunsaturated Fatty Acids ◽  
Vascular Dementia ◽  
Cognitive Functions ◽  
Control Group ◽  
Omega 3

Снижение когнитивных функций вплоть до развития деменции у пожилых людей связывают с уменьшением в крови уровня полиненасыщенных жирных кислот, особенно Омега-3, которое происходит на фоне окислительного стресса. В работе представлен сравнительный анализ спектра полиненасыщенных жирных кислот и активности отдельных компонентов ферментативной антиоксидантной системы в крови у лиц пожилого возраста с нарушением показателей когнитивного функционирования до уровня «мягкое когнитивное снижение» первично-атрофической (MCI БА, продромальная болезнь Альцгеймера) или васкулярной этиологии (MCI СД, продромальная сосудистая деменция) по сравнению с пожилыми людьми без признаков нарушений когнитивных функций. Выявлено снижение концентрации Омега-3 полиненасыщенных жирных кислот в крови обеих групп обследованных больных по сравнению с контрольной группой. У пациентов с MCI БА обнаружено резкое снижение концентрации арахидоновой кислоты (Омега-6) по сравнению с больными MCI СД и контрольной группой. Выявленное нами снижение активности антиоксидантной ферментативной системы и снижение полиненасыщенных жирных кислот за счет их пероксидации свидетельствует об интенсификации процессов окислительного стресса у пациентов с нарушением когнитивных функций. Обсуждается вопрос о патогенетической роли арахидоновой кислоты у больных, предрасположенных в будущем к развитию болезни Альцгеймера. A decrease in cognitive functions up to the development of dementia in the elderly is associated with a decrease in the blood level of polyunsaturated fatty acids, especially Omega-3, which occurs against the background of oxidative stress. The paper presents a comparative analysis of the spectrum of polyunsaturated fatty acids and the activity of individual components of the enzymatic antioxidant system in the blood of elderly people with impaired cognitive performance to the level of «mild cognitive decline» (MCI AD, prodromal Alzheimer’s disease) or vascular etiology (MCI VaD, prodromal vascular dementia) compared with older people without signs of cognitive impairment. A decrease in the concentration of Omega-3 polyunsaturated fatty acids in the blood of both groups of the examined patients was revealed compared with the control group. In patients with AD MCI, a sharp decrease in the concentration of arachidonic acid (Omega-6) was detected compared with patients with MCI VaD and the control group. The decrease in the activity of the antioxidant enzymatic system and the decrease in polyunsaturated fatty acids due to their peroxidation revealed in this study indicate an intensification of the OS processes in patients with impaired cognitive functions. The question of the pathogenetic role of arachidonic acid in patients predisposed in the future to the development of AD is discussed.

scholarly journals Genetic markers of decline human cognitive functions in Alzheimer`s disease

2018 ◽  
pp. 14-19
Author(s):  
А.В. Бочарова ◽  
А.В. Марусин ◽  
О.А. Макеева ◽  
И.А. Жукова ◽  
Н.Г. Жукова ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Markers ◽  
Cognitive Functions ◽  
Control Design ◽  
Case Control ◽  
Minor Allele ◽  
Russian Population ◽  
Polymorphic Variant ◽  
Control Group

Проведено репликативное ассоциативное исследование в дизайне случай-контроль 30 однонуклеотидных полиморфных вариантов генов, показавших высокодостоверную ассоциацию с когнитивными функциями, болезнью Альцгеймера (БА) или шизофренией по данным полногеномных ассоциативных исследований и метаанализам. Была установлена статистически достоверная ассоциация полиморфного варианта rs12922317 гена SNX29 с фенотипом БА, что в других работах не встречалось. Минорный аллель G rs12922317 гена SNX29 достоверно чаще встречался среди больных БА по сравнению с контрольной группой (OR = 1,57, 95% CI 1,14-2,16, p = 0,006). В других работах была показана роль полиморфного маркера rs12922317 гена SNX29 в развитии таких заболеваний, как шизофрения, В-клеточная лимфома яичка и эпителиальная овариальная карцинома. We have held a replication associative study in case-control design of 30 SNPs of genes that showed association with cognitive functions or Alzheimer’s disease or schizophrenia according to the data of GWAS. A statistically significant association of the polymorphic variant rs12922317 of SNX29 gene with the Alzheimer’s disease in the Russian population was established, which was not found in other studies. Minor allele G rs12922317 of SNX29 gene was significantly more frequent among patients with the Alzheimer’s disease compared with control group (OR = 1.57, 95% CI 1.14-2.16, p = 0.006), and according to GWAS this marker was associated with schizophrenia.

Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer’s disease: a randomised, double-blind, placebo-controlled trial

2019 ◽  
pp. jnnp-2018-320199 ◽  
Author(s):  
Jingya Jia ◽  
Jing Hu ◽  
Xiaoxu Huo ◽  
Rujuan Miao ◽  
Yanping Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin D ◽  
Cognitive Function ◽  
Digit Span ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Double Blind ◽  
Double Blind Placebo

ObjectiveOur study aimed to assess the effect of a 12-month vitamin D supplementation on cognitive function and amyloid beta (Aβ)-related biomarkers in subjects with Alzheimer’s disease (AD).Methods This was a randomised, double-blind, placebo-controlled trial. 210 AD patients were randomly divided into intervention and control groups. Participants received 12-month 800 IU/day of vitamin D or starch granules as placebo. Tests of cognitive performance and Aβ-related biomarkers were measured at baseline, 6 months and 12 months.Results Repeated-measures analysis of variance showed significant improvements in plasma Aβ42, APP, BACE1, APPmRNA, BACE1mRNA (p<0.001) levels and information, arithmetic, digit span, vocabulary, block design and picture arrange scores (p<0.05) in the intervention group over the control group. According to mixed-model analysis, vitamin D group had significant increase in full scale IQ during follow-up period (p<0.001).ConclusionsDaily oral vitamin D supplementation (800 IU/day) for 12 months may improve cognitive function and decrease Aβ-related biomarkers in elderly patients with AD. Larger scale longer term randomised trials of vitamin D are needed.Trial registration numberChiCTR-IIR-16009549.

scholarly journals Mini Nutritional Assessment May Identify a Dual Pattern of Perturbed Plasma Amino Acids in Patients with Alzheimer’s Disease: A Window to Metabolic and Physical Rehabilitation?

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1845
Author(s):  
Roberto Aquilani ◽  
Alfredo Costa ◽  
Roberto Maestri ◽  
Matteo Cotta Ramusino ◽  
Antonia Pierobon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Verbal Memory ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Nutritional State ◽  
Control Group ◽  
Cognitive Tests ◽  
Memory And Attention ◽  
Branched Chain

Conflicting results about alterations of plasma amino acid (AA) levels are reported in subjects with Alzheimer’s disease (AD). The current study aimed to provide more homogeneous AA profiles and correlations between AAs and cognitive tests. Venous plasma AAs were measured in 54 fasting patients with AD (37 males, 17 females; 74.63 ± 8.03 yrs; 3.2 ± 1.9 yrs from symptom onset). Seventeen matched subjects without neurodegenerative symptoms (NNDS) served as a control group (C-NNDS). Patients were tested for short-term verbal memory and attention capacity and stratified for nutritional state (Mini Nutritional Assessment, MNA). Compared to C-NNDS, patients exhibited lower plasma levels of aspartic acid and taurine (p < 0.0001) and higher 3-methylhistidine (p < 0.0001), which were independent of patients’ MNA. In comparison to normonourished AD, the patients at risk of and with malnutrition showed a tendency towards lower ratios of Essential AAs/Total AAs, Branched-chain AAs/Total AAs, and Branched-chain AAs/Essential AAs. Serine and histidine were positively correlated with verbal memory and attention capacity deficits, respectively. Total AAs negatively correlated with attention capacity deficits. Stratifying patients with AD for MNA may identify a dual pattern of altered AAs, one due to AD per se and the other linked to nutritional state. Significant correlations were observed between several AAs and cognitive tests.

Effect Of Nhexane Extract Of Caryota No Seed On Markers Of Neurodegeneration And Fecundity In Drosophila Melanogaster

2020 ◽  
Vol 6 (5) ◽  
pp. 1-7
Author(s):  
Chinonye A Maduagwuna ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drosophila Melanogaster ◽  
Neurodegenerative Diseases ◽  
Cognitive Functions ◽  
The Elderly ◽  
Common Cause ◽  
Chronic Neuroinflammation

Study background: Chronic neuroinflammation is a common emerging hallmark of several neurodegenerative diseases. Alzheimer’s Disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions.

Depressive Symptoms and APOE ε2 Broad the Natural History in Presenilin-1 E280A Familial Early-Onset Alzheimer's Disease

2018 ◽  
Author(s):  
Natalia Acosta-Baena ◽  
Carlos Mario Lopera-G&oacute;mez ◽  
Mario C&eacute;sar Jaramillo-Elorza ◽  
Margarita Giraldo-Chica ◽  
Mauricio Arcos-Burgos ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
Natural History ◽  
Early Onset ◽  
Presenilin 1 ◽  
Early Onset Alzheimer’S Disease
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