Physician Treatment of Osteoporosis in Response to Heel Ultrasound Bone Mineral Density Reports

2002 ◽  
Vol 5 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Joan L. Boyd ◽  
John P. Holcomb ◽  
R.J. Rothenberg
2013 ◽  
Vol 3 ◽  
pp. 23 ◽  
Author(s):  
Sunanda Bhatnagar ◽  
Vasavi Krishnamurthy ◽  
Sandeep S. Pagare

Objective: The aim of the study was to evaluate panoramic radiograph, a commonly taken dental radiograph as a screening tool to detect early osseous changes (normal, mildly or severely eroded) of the mandibular inferior cortex and measure the mandibular cortical width (CW) in post-menopausal women and correlate it with the bone mineral density (BMD) measured by the ultrasound bone sonometer at the mid-shaft tibia region. Materials and Methods: The study included females between 45 years and 65 years of age in their post-menopausal stage (no menstruation for at least 6-12 months). Mandibular indices (mandibular CW and mandibular cortical shape) were evaluated from panoramic radiographs. The BMD assessment was carried out at the mid-shaft tibia region, exactly half-way between the heel and the knee joint perpendicular to the direction of the bone, using an ultrasound bone sonometer. It is a non-invasive device designed for quantitative measurement of the velocity of ultrasound waves as speed of sound in m/s, capable of measuring bone density at one or more skeletal sites. Using 1994 WHO criteria the study subjects were categorized as Group 1: Normal, Group 2: Osteopenia, Group 3: Osteoporosis. (WHO T score for tibia BMD can be used as a standard). Results: The diagnostic efficacy of the panoramic radiograph in detecting osseous changes in post-menopausal women with low BMD was shown to have 96% specificity and 60% sensitivity with mandibular cortical shape and 58% specificity and 73% sensitivity with mandibular CW measurement. Factorial ANOVA analysis carried out indicated a significant correlation of BMD classification with mandibular cortical shape (F = 29.0, P < 0.001, partial eta squared [η2] =0.85), a non-significant correlation with mandibular CW, (F = 1.6, P = 0.23, η2 = 0.86), and a more significant correlation with combined cortical shape and width (F = 3.3, P < 0.05, η2 = 0.70). Conclusion: The study concludes that the combined mandibular cortical findings (P < 0.05) and mandibular cortical shape erosion alone (P < 0.001) on panoramic radiograph are effective indicators of osteoporosis in post-menopausal women.


2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Bin Wu ◽  
Jie-Feng Huang ◽  
Bang-Jian He ◽  
Chen-Wei Huang ◽  
Jian-Hua Lu

Objective. To systematically evaluate the effects of red yeast rice (RYR) and its extract on bone formation in experimental animals and to provide reference data for clinical research on the treatment of osteoporosis. Methods. Chinese and English language databases, including Web of Science, PubMed, the Cochrane Library, Elsevier, Google Scholar, SpringerLink, Embase, China National Knowledge Infrastructure (CNKI), Weipu Chinese Sci-tech periodical full-text database (VIP), and Wanfang Data Knowledge Service Platform (Wanfang), were searched from their establishment to February 2020 using the following terms: “hongqu,” “red yeast rice,” “Monascus purpureus-fermented rice,” “bone mineral density,” “osteoblast,” “osteoporosis,” and “animal models.” After excluding nonrelevant articles, Review Manager 5.2 was used to evaluate article quality and to analyze the data. Outcome indicators included bone mineral density (BMD), osteoblast proliferation, and the expression of alkaline phosphatase (ALP). Results. A total of 11 randomized controlled trials were included in the meta-analysis, all of which were animal studies. Six studies included data on BMD, five on osteoblast proliferation, and six on the expression of ALP. The results of the meta-analysis showed that RYR can significantly improve BMD (standardized mean difference SMD=3.12, 95% confidence interval (CI) 1.41 to 4.83, P=0.0003), promote osteoblast proliferation (SMD=1.64, 95% CI 1.04 to 2.23, P<0.00001), and increase ALP expression in rats (SMD=1.25, 95% CI 0.69 to 1.80, P<0.00001). Conclusions. RYR can promote bone formation in experimental animals and may be useful for the treatment of osteoporosis.


PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31726 ◽  
Author(s):  
Amandine Cournil ◽  
Sabrina Eymard-Duvernay ◽  
Assane Diouf ◽  
Claire Moquet ◽  
Julie Coutherut ◽  
...  

ASJ. ◽  
2021 ◽  
Vol 1 (56) ◽  
pp. 28-33
Author(s):  
O. Kalinkina ◽  
Yu. Tezikov ◽  
I. Lipatov

87 patients aged 40-69 years in the period of pre- and postmenopause were examined. In the analysis of age-related dynamics of bone mineral density (BMD) It was found that densitometry indicators corresponding to osteoporosis directly correlate with age and duration of the postmenopausal period. It is advisable in women of this age group with a decrease in bone mineral density, the combined appointment of menopausal hormone therapy (MGT) and non-hormonal therapy affecting bone metabolism (calcitonin). For the purpose of MGT in premenopausal women, the use of femostone 2/10 is effective, in postmenopausal women - femostone 1/10 and femostone 1/5, which does not cause withdrawal bleeding. If there are contraindications to menopausal hormone therapy, the prevention and treatment of osteoporosis should be guided by the appointment of nonhormonal drugs, in particular, calcitonin.


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