scholarly journals Effects of 2 Years' Treatment of Osteoporosis with 1 a-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture: A Placebo-Controlled, Double-Blind Prospective Study.

1996 ◽  
Vol 43 (2) ◽  
pp. 211-220 ◽  
Author(s):  
MASATAKA SHIRAKI ◽  
KAZUHIRO KUSHIDA ◽  
KAORU YAMAZAKI ◽  
TSUNEJI NAGAI ◽  
TETSUO INOUE ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Mineral Density ◽  
Double Blind ◽  
Treatment Of Osteoporosis

17p-estradiol (1 mg daily) in continuous combination with dydrogesterone (5.10 or 20 mg daily) increases bone mineral density in postmenopausal women

2021 ◽  
Vol 50 (4) ◽  
pp. 67-71
Author(s):  
J. С. Stevenson ◽  
P. Teter ◽  
В. Lees
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Randomized Study ◽  
Lumbar Vertebrae ◽  
Mineral Density ◽  
Double Blind ◽  
Treatment Of Osteoporosis ◽  
Hip Bmd

Although the minimal dose of 17/3-estradiol in hormone replacement regimens was originally considered to be 2 mg a day, it is now increasingly accepted that a lower dose of 1 mg a day is effective in protecting women from the detrimental effects of the menopause. A 1-year, multicentre, double-blind, randomized study was conducted in 214 healthy postmenopausal women in order to assess the effect of 17(3-estradiol (1 mg a day) continuously combined with dydrogesterone (5,10 or 20 mg/day) in preventing bone loss. Bone mineral density (BMD) was evaluable in 177 women who completed the study. In all women, a statistically significant increase from baseline in lumbar vertebrae (L.2~L4) BMD was seen after 6 months (+ 2,4%; p0,01); this increase was somewhat greater after 12 months (+ 3,6%;p 0,01). Similar effects were seen in the hip. After 6 months, BMD in the femoral neck, Wards triangle and trochanter had increased by 0,20% (not significant [n.s.]), 0,32% (n.s.)and 1,08% (p0,01), respectively, compared with baseline. Greater increases were again seen after 12 months (+1,16%, + 1,62% and +2,83%, respectively), all of which were statistically significant (p0,01) compared with baseline. The change in BMD from baseline did not diff er significantly between the three dydrogesterone dosages for either L.2~L4 or hip. All dosages were well tolerated and amenorrhoea was achieved in over 70%. In conclusion, 17(3-estradiol (1 mg/day) continuously combined with dydrogesterone (5, 10 or 20 mg/day) results in a significant increase in lumbar vertebrae and hip BMD in postmenopausal women. The lower dose of oestrogen and the avoidance of cyclical bleeding make this a particularly suitable regimen for the prevention and treatment of osteoporosis in older women.

Bone mineral density in girls with functional hypothalamic amenorrhea subjected to estroprogestagen treatment: a 4-year prospective study

2014 ◽  
Author(s):  
Elzbieta Sowinska-Przepiera ◽  
Elzbieta Andrysiak-Mamos ◽  
Agnieszka Kazmierczyk-Puchalska ◽  
Ewa Wentland-Kotwicka ◽  
Anhelli Syrenicz
Keyword(s):  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Hypothalamic Amenorrhea ◽  
Functional Hypothalamic Amenorrhea

Radial bone mineral density in pre- and perimenopausal women: A prospective study of rates and risk factors for loss

2009 ◽  
Vol 7 (6) ◽  
pp. 647-657 ◽  
Author(s):  
Maryfran R. Sowers ◽  
M. Kathleen Clark ◽  
Bruce Hollis ◽  
Robert B. Wallace ◽  
Mary Jannausch
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Perimenopausal Women ◽  
A Prospective Study ◽  
Radial Bone

scholarly journals The effects of bendroflumethiazide on bone mineral density measured using DXA, QCT and VFA; a randomized double-blind placebo-controlled cohort study

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100571
Author(s):  
Thomas Emmanuel ◽  
Julius Simoni Leere ◽  
Christian Kruse ◽  
Trine Holmgaard Poulsen ◽  
Peter Vestergaard
Keyword(s):  
Bone Mineral Density ◽  
Cohort Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Double Blind ◽  
Double Blind Placebo
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