Association of Different Zinc Concentrations Combined with a Fixed Caffeine Dose on Plasma and Tissue Caffeine and Zinc Levels in the Rat

2002 ◽  
Vol 87 (1-3) ◽  
pp. 183-190 ◽  
Author(s):  
Malektaj Yazdani ◽  
Sheila Gottschalk ◽  
Kazuya Ide ◽  
Tetsuo Nakamoto
Keyword(s):  
Zinc Concentrations ◽  
Zinc Levels

Evaluation of Metal Contents in Correlation with Phytosanitary Treatments at Vineyard

2017 ◽  
Vol 68 (6) ◽  
pp. 1289-1293
Author(s):  
Oana Mihai ◽  
Octav Pantea ◽  
Daniela Roxana Popovici ◽  
Catalina Gabriela Gheorghe
Keyword(s):  
Soil Samples ◽  
Flame Atomic Absorption ◽  
Mobile Forms ◽  
Before And After ◽  
Phytosanitary Treatment ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Ph Range ◽  
In The Beginning ◽  
Short Time

The present work aims with the evaluation of copper, manganese and zinc concentrations (mobile forms) from vineyard soil before and after phytosanitary treatment with Curzate Manox and Dithane M-45 compounds, during and after remanence period. Different vineyard soils types were collected at 0-20 cm and 20-40 cm depths. Flame Atomic Absorption Spectroscopy (FAAS) method was used for measurements of the micronutrients. The soil samples were analyzed after 5 and 21 days after treatment application. Since copper is mainly accumulates in the upper layer following fungicidal sprays application, high levels of copper concentrations are obtained. The soil samples exhibits different behavior in terms of manganese and zinc contents. Manganese and zinc levels are classified as medium in the beginning of the experiment (Mn-M0 and Zn-M0), whereas these levels increased in the soil samples (at moments M1- 5 days and M2- 21 days after treatment). This behavior can be due to the Mancozeb decomposition, knowing that Mancozeb decomposes in the pH range 5-9 and it remains short time into the soil.

Measurement of Hypozincaemia in Mice: A Sensitive Test for Detection of Pyrogens

1981 ◽  
Vol 61 (4) ◽  
pp. 445-449 ◽  
Author(s):  
Susan Boobis ◽  
Rose E. Hartley
Keyword(s):  
Escherichia Coli ◽  
Zinc Concentration ◽  
Shigella Dysenteriae ◽  
Metabolic Inhibitor ◽  
Repeated Treatment ◽  
Plasma Zinc ◽  
Sensitive Test ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Dose Dependent

1. The effect of bacterial pyrogens on plasma zinc concentration in mice was studied as a method of bioassay for these substances. 2. A dose-related depression of plasma zinc concentrations was observed 4 h after intravenous injection of doses of 0.05-500 ng of purified endotoxins of Salmonella abortus equi, Shigella dysenteriae and Escherichia coli. Responses were dose-dependent and reproducible for each endotoxin in five strains of mice. 3. Tolerance to endotoxin could be induced in mice by injection of doses of 500 ng but was not seen with doses of <5 ng, even after repeated treatment. 4. Dinitrophenol, a metabolic inhibitor, and amphetamine, a metabolic enhancer, did not affect plasma zinc levels, indicating that changes in basal metabolic rate do not affect the outcome of this assay. The effects of pyrogenic materials other than endotoxin on plasma zinc levels were also tested and the results suggest that measurement of hypozincaemia in mice provides the basis for a simple, practical and inexpensive test for endotoxins and other pyrogens.

scholarly journals Clinical Significance of Serum Zinc Levels in Cerebral Ischemia

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Archit Bhatt ◽  
Muhammad U. Farooq ◽  
Sailaja Enduri ◽  
Clement Pillainayagam ◽  
Bharath Naravetla ◽  
...  
Keyword(s):  
Functional Status ◽  
Serum Zinc ◽  
Stroke Severity ◽  
Stroke Outcome ◽  
Cellular Functions ◽  
Zinc Concentrations ◽  
Poor Functional Status ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

Background. Zinc mediates several vital physiological, enzymatic and cellular functions. The association between serum zinc and stroke outcome has not been previously evaluated.Methods. This single center retrospective study was conducted on consecutive stroke () and TIA () patients. We sought to determine whether serum zinc concentrations in patients with acute ischemic strokes were associated with stroke severity and poor functional status at discharge, respectively.Results. Overall, out of the 224 patients analyzed (mean age 67 years), 35.7% patients had low zinc levels (65 mcg/dL). Patients with stroke () were more likely to have low zinc levels (, CI , ) compared to patients with TIA (). For patients with stroke (), multivariate analysis showed that low serum zinc levels (OR 2.82, CI , ) and strokes with admission severe strokes () (OR 2.68, CI , ) were independently associated with poor functional status () at discharge from the hospital.Conclusion. Low serum zinc concentrations are associated with more severe strokes on admission and poor functional status at discharge.

EDTA toxicity and background concentrations of copper and zinc in Hyalella azteca

1995 ◽  
Vol 52 (4) ◽  
pp. 875-881 ◽  
Author(s):  
U. Borgmann ◽  
W. P. Norwood
Keyword(s):  
Culture Media ◽  
Hyalella Azteca ◽  
Dry Weight ◽  
Complexing Agent ◽  
Copper Uptake ◽  
Background Concentrations ◽  
Copper And Zinc ◽  
Metal Levels ◽  
Zinc Concentrations ◽  
Zinc Levels

The effect of the strong metal-complexing agent EDTA on survival, growth, and copper and zinc concentrations in Hyalella azteca was studied to determine if metal concentrations in control amphipods represent minimum physiological levels. Exposure to EDTA concentrations of up to 560 μM for 1 week did not reduce metal levels (mean background = 1.2 μmol Cu/g and 1.0 μmol Zn/g dry weight), indicating that background metals are firmly bound to Hyalella. Chronic (4 week) exposure to EDTA resulted in increased mortality and reduced growth rates, both of which could be partially ameliorated by adding zinc to culture media. This implies that EDTA toxicity results, in part, from zinc deficiency. In spite of this, however, zinc concentrations in Hyalella were not reduced in amphipods raised in the presence of high EDTA, implying that the observed background zinc levels represent minimum physiological levels. Copper additions to media were ineffective at reducing EDTA toxicity. Nevertheless, control concentrations are probably close to minimum physiological levels for copper as well, because high EDTA did not appreciably reduce copper in Hyalella in chronic tests, in spite of its ability to impair copper uptake from water at moderate water concentrations.

scholarly journals Lower Serum Zinc Levels in Patients with Multiple Sclerosis Compared to Healthy Controls

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 967 ◽  
Author(s):  
Marc Pawlitzki ◽  
Julia Uebelhör ◽  
Catherine Sweeney-Reed ◽  
Heike Stephanik ◽  
Juliane Hoffmann ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Serum Zinc ◽  
Healthy Controls ◽  
Lower Serum ◽  
Disability Status ◽  
Zinc Concentrations ◽  
Disease Subtypes ◽  
Disease Modifying ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective: Diminished blood levels of zinc have been reported to be associated with T-cell-mediated autoimmunity, which has been implicated in multiple sclerosis (MS). We aimed to compare the distribution of serum zinc status in MS patients with that in healthy controls (HCs) and to investigate a potential correlation with clinical state, through analysis of serum zinc concentration in MS patients suffering from different disease subtypes. Methods: Serum zinc concentrations of 133 patients with relapsing (RMS) and 18 patients with the progressive form of MS (PMS), according to the McDonald criteria of 2010, were measured. Clinical status was quantified using the Expanded Disability Status Scale (EDSS). Zinc concentrations were also determined in the sera of 50 HCs, matched for age and sex at a group level. Results: MS patients showed significantly lower zinc concentrations (mean (SD)) than HCs (12.5 (2.1) µmol/L vs. 14.6 (2.3) µmol/L, p < 0.001). In contrast, we did not find any difference between RMS (12.4 (2.0) µmol/L) and PMS (13.0 (3.0) µmol/L) cases (p = 0.8). Patients receiving disease-modifying treatment showed lower mean (SD) serum zinc levels than untreated cases (12.3 (1.9) µmol/L vs. 13.5 (3.2) µmol/L, p < 0.03). Zinc levels were not related to disease duration, EDSS, annual relapse rate, or the median number of relapses. Conclusions: The data suggest that a diagnosis of MS is related to lower serum zinc concentrations than in HCs, and concentrations were lower still under disease-modifying therapy. However, zinc levels did not predict disease subtypes or disability status.

The Return of Atlantic Salmon Salmo salar to Trout Lake, North Bay, Ontario

1997 ◽  
Vol 32 (2) ◽  
pp. 347-364
Author(s):  
Dave Maraldo ◽  
Brad Bowman ◽  
Mike Gillies
Keyword(s):  
Rainbow Trout ◽  
Atlantic Salmon ◽  
Salmo Salar ◽  
Exposure Period ◽  
Water Quality Monitoring ◽  
Trout Lake ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Creek Watershed ◽  
Zinc Concentrations ◽  
Zinc Levels

Abstract In 1935, landlocked Atlantic salmon or ouananiche Salmo salar were introduced into Trout Lake, a 1,674-ha oligotrophic lake. The salmon reproduced in Four Mile Creek and became the only naturally reproducing population in Ontario. Anglers reported good catches of salmon in the 1950s and 60s, with fish up to 6 kg taken. In 1967, a train derailment resulted in the spillage of an unspecified volume of zinc concentrate into the Four Mile Creek watershed. Water quality monitoring completed in 1979 documented zinc levels in Four Mile Creek downstream of the derailment area ranging from 130 to 340 µg/L. In retrospect, it was believed that this elevated level of zinc resulted in adult salmon avoiding Four Mile Creek. Since this was the only stream suitable for spawning, reproduction ceased and salmon disappeared. The last known catch of Atlantic salmon in Trout Lake occurred in the early 1970s. In 1980, approximately 250,000 tonnes of zinc-contaminated soil was excavated from the area. In situ toxicity studies in 1981 produced 20% mortality of rainbow trout Oncorhynchus mykiss yearlings during a 48-hour exposure period downstream of the derailment area. In-stream zinc concentrations ranged from 110 to 160 µg/L during the exposure period. Rainbow trout stocked into Four Mile Creek from 1983-88 survived. Atlantic salmon were first reintroduced in 1989 as fall fingerlings. Adult salmon appeared in the creek in November 1992, and again in 1994 and 1995. Electrofishing studies confirmed the presence of naturally reproduced juvenile salmon in 1994 and 1995. As yet the population of adult salmon in Trout Lake is low but may increase as naturally reproduced salmon smolt and enter the lake. Zinc concentrations in Four Mile Creek have continued to decline as a function of time. In 1994, they ranged from 7 to 48 µg/L.

The Inheritance of Plasma and Red Blood Cell Magnesium and Zinc Levels Studied From Twin and Family Data

1981 ◽  
Vol 30 (1) ◽  
pp. 67-75 ◽  
Author(s):  
P. Darlu ◽  
Y. Michotte ◽  
E. Defrise-Gussenhoven ◽  
J.G. Henrotte
Keyword(s):  
Blood Cell ◽  
Family Environment ◽  
Red Blood Cell ◽  
Genetic Regulation ◽  
The Family ◽  
Diverse Environment ◽  
Living Together ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Plasma Magnesium

The variability of magnesium and zinc concentrations in plasma and erythrocytes was investigated by twin and family studies. Twins were sampled in two distinct ways and in two different West-European regions. In one of the samples, a distinction was made between twins living together and twins living apart. Two series of families were studied, one in a homogeneous environment, the other in a more diverse environment. Samples were compared by variance analysis. The results show 1) that genetic variability is significant for red blood cell (RBC) magnesium and zinc, minor for plasma magnesium and absent for plasma zinc; 2) that the family environment affects the extent of resemblance between twins and between siblings more for plasma levels than for RBC levels of magnesium and zinc. Furthermore, the intercorrelation analysis suggests that the genetic regulation systems of RBC magnesium and zinc are different, whereas some of the environmental regulation systems of plasma magnesium and zinc are the same. Biological interpretations are brought forward and discussed.

Thymus metallothionein: regulation of zinc-thionein in the aging mouse

1985 ◽  
Vol 63 (2) ◽  
pp. 91-95 ◽  
Author(s):  
R. W. Olafson
Keyword(s):  
New Zealand ◽  
Early Onset ◽  
Molecular Basis ◽  
Mouse Thymus ◽  
Age Related ◽  
Thymus Tissue ◽  
Aging Mouse ◽  
Zinc Concentrations ◽  
Zinc Levels ◽  
Immune Dysfunctions

The presence of a zinc-inducible metallothionein in mouse thymus tissue has been shown, together with an age-related modulation of zinc, metallothionein, and thymus mass. Metallothionein (MT) and zinc concentrations were found to be maximum prior to completion of thymic growth and to be at a minimum when development of the thymus had ceased. Subsequent transient outgrowths of the thymus during involution showed similar associated fluctuations of MT and zinc levels. A marked difference in the latter parameters was found on comparison with New Zealand Black mice known for development of early onset autoimmunities. These findings provide a new avenue for both investigation of the regulation of zinc in thymus tissue, as well as the possible elucidation of the molecular basis for certain age-related immune dysfunctions.

Zinc dyshomeostasis in azoxymethane induced colonic precancerous and cancerous lesions in Fisher rats

Metallomics ◽  
2020 ◽  
Author(s):  
Kavitha Velagapudi ◽  
J Naveena Lavanya Latha ◽  
Vijaya Lakshmi Bodiga
Keyword(s):  
Bystander Effect ◽  
Zinc Concentration ◽  
Precancerous Lesions ◽  
Serum Zinc ◽  
Zinc Homeostasis ◽  
Dna Integrity ◽  
Normal Colonic Mucosa ◽  
Altered Expression ◽  
Zinc Concentrations ◽  
Zinc Levels

Abstract Zinc is an essential micronutrient involved in various biological processes, including growth, maintenance, proliferation and immune functions. It is also argued that tumors need zinc for maintenance and proliferation, although excess zinc may induce tumor cell apoptosis. Thus, the role of zinc merits attention in the carcinogenic process. Scanty literature is available on the mechanisms underlying the alterations in tissue zinc in colon cancer and how the altered zinc levels contribute to the preneoplastic lesions and progression to cancer. Zinc homeostasis is regulated by the gastrointestinal tract and involves interplay of host, dietary, environmental and social factors such as alcohol consumption. The DNA alkylation agent azoxymethane (AOM), which is primarily activated in the liver, induces a high incidence of initiation and promotion steps of precancerous lesions in the colon of rats. The altered expression of hepatic zinc transporters by AOM may lead to zinc dyshomeostasis in liver. Earlier reports showed that ZIP14 was located on the inner lane of plasma membrane of hepatocytes, and increased level of ZIP14 could sequester zinc from plasma into liver under infection or in response to cancer. Decreased serum zinc concentration, despite increased liver zinc also indicates altered liver zinc mobilization and failure to regulate zinc homeostasis. During the transformation from normal colonic mucosa to colonic epithelial hyperplasia and aberrant crypt formation, a reduction in zinc concentration is observed. It will be interesting to study further if the same trend continues throughout tumor progression towards adenocarcinomas. Lowered local zinc concentrations in the colon epithelium may not just reflect a bystander effect, but may induce cell proliferation and compromise DNA integrity due to impairment of zinc-containing proteins. In congruence with the tissue zinc concentrations, metallothionein levels were found to be less induced in AOM—administered colon compared to normal healthy colon, indicating less accumulation and sequestration of zinc. Lowered tissue zinc levels in small and large intestine were also associated with increased expression of mRNA and protein ZnT1, known to transport cytosolic zinc to extracellular space. In this regard, the mode of zinc responsiveness to ZnT1 mimics that of metallothionein, albeit at a lower level for ZnT1.

Oral contraceptives, norethindrone and mestranol: effects on tissue levels of minerals

1976 ◽  
Vol 231 (1) ◽  
pp. 98-103 ◽  
Author(s):  
KY Lei ◽  
AS Prasad ◽  
E Bowersox ◽  
D Oberleas
Keyword(s):  
Causative Factor ◽  
Atomic Absorption Spectrophotometry ◽  
Plasma Zinc ◽  
Sprague Dawley ◽  
Liver Iron ◽  
Zinc Intake ◽  
Sprague Dawley Rats ◽  
Plasma Copper ◽  
Zinc Concentrations ◽  
Zinc Levels

The study involved three levels of dietary zinc (deficient, marginal, and adequate) and four hormonal conditions; namely, no steriods, norethindrone, mestranol, and norethindrone plus mestranol. The steroids were incorporated into diets and fed to 11-wk-old female Sprague-Dawley rats. After 10 wk of treatment, various tissues were excised for mineral assays by atomic-absorption spectrophotometry. Both steroids, reduced weight gain. Mestranol depressed plasma zinc, tibia copper and magnesium, and liver iron, but elevated the zinc levels in liver and erythrocytes, plasma copper, liver magnesium and calcium, and iron content of tibia and heart. In general, the effect was most prominent with adequate zinc but diminished in magnitude with the reduction of zinc intake. In addition, norethindrone increased heart iron and tibia calcium. Mestranol appeared to be the main causative factor and may have induced a possible shift of minerals from one pool to another. As expected, zinc deficiency resulted in the reduction of zinc concentrations of plasma, tibia, kidney, and pancreas, and the elevation of copper, iron, magnesium, and calcium concentrations of various tissues.

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