Optical weak measurement system with common path implementation for label-free biomolecule sensing

2016 ◽  
Vol 41 (22) ◽  
pp. 5409 ◽  
Author(s):  
Yilong Zhang ◽  
Dongmei Li ◽  
Yonghong He ◽  
Zhiyuan Shen ◽  
Qinghua He
Keyword(s):  
Measurement System ◽  
Weak Measurement ◽  
Label Free ◽  
Common Path ◽  
Biomolecule Sensing

scholarly journals A Differential Detection Method Based on a Linear Weak Measurement System

Sensors ◽  
2019 ◽  
Vol 19 (11) ◽  
pp. 2473
Author(s):  
Nian Xiong ◽  
Tian Guan ◽  
Yang Xu ◽  
Lixuan Shi ◽  
Suyi Zhong ◽  
...  
Keyword(s):  
Measurement System ◽  
Total Internal Reflection ◽  
High Stability ◽  
Detection Method ◽  
Weak Measurement ◽  
Internal Reflection ◽  
Differential Detection ◽  
Label Free ◽  
Label Free Detection ◽  
Linear Differential

Self-reference detection is necessary and important to a biosensor. The linear weak measurement system based on total internal reflection has attracted widespread attention due to its high stability, label-free detection, and easy integration. In this paper, we propose a differential detection method based on the linear total internal reflection weak measurement system. We introduce the half-wave plate (HWP) to convert the H light and the V light to each other, thereby obtaining the difference in phase change of the optical path before and after the HWP. Experiments show that the system can not only achieve differential detection, but also has high stability. The linear differential weak measurement system proposed in this paper not only provides a new differential measurement method for real-time biosensors, but also enriches the types of weak measurement sensors.

Development of Bioimpedance Sensors and Measurement System for Biomedical In-Vitro Applications

2021 ◽  
Vol 7 (2) ◽  
pp. 496-499
Author(s):  
Stadler B. Eng. Sebastian ◽  
Herbert Plischke ◽  
Christian Hanshans
Keyword(s):  
Measurement System ◽  
Low Cost ◽  
Measurement Data ◽  
Impedance Measurement ◽  
Microtiter Plate ◽  
Label Free ◽  
Single Chip ◽  
Do It Yourself ◽  
Store And Forward

Abstract Bioimpedance analysis is a label-free and easy approach to obtain information on cellular barrier integrity and cell viability more broadly. In this work, we introduce a small, low-cost, portable in vitro impedance measurement system for studies where a shadow-free exposure of the cells is a requirement. It can be controlled by a user-friendly web interface and can perform measurements automated and autonomously at short intervals. The system can be integrated into an existing IoT network for remote monitoring and indepth analyses. A single-board computer (SBC) serves as the central unit, to control, analyze, store and forward the measurement data from the single-chip impedance analyzer. Various materials and manufacturing methods were used to produce a purpose-built lid on top of a modified 24-well microtiter plate in a “do it yourself” fashion. Furthermore, three different sensor designs were developed utilizing anodic aluminum oxide (AAO) membranes and gold-plated electrodes. Preliminary tests with potassium chloride (KCl) showed first promising results.

Multifunctional weak measurement system that can measure the refractive index and optical rotation of a solution

2019 ◽  
Vol 114 (18) ◽  
pp. 181901 ◽  
Author(s):  
Yang Xu ◽  
Lixuan Shi ◽  
Tian Guan ◽  
Suyi Zhong ◽  
Xuesi Zhou ◽  
...  
Keyword(s):  
Refractive Index ◽  
Measurement System ◽  
Optical Rotation ◽  
Weak Measurement

Optimization of a quantum weak measurement system with digital filtering technology

2018 ◽  
Vol 57 (27) ◽  
pp. 7956 ◽  
Author(s):  
Yang Xu ◽  
Lixuan Shi ◽  
Tian Guan ◽  
Dongmei Li ◽  
Yuxuan Yang ◽  
...  
Keyword(s):  
Measurement System ◽  
Digital Filtering ◽  
Weak Measurement

Label-free Optical Detection of Molecular Interactions by Molecular Interferometric Imaging

2008 ◽  
Vol 1133 ◽  
Author(s):  
Ming Zhao ◽  
Xuefeng Wang ◽  
David. D. Nolte
Keyword(s):  
Real Time ◽  
Optical Biosensor ◽  
Array Detector ◽  
Label Free ◽  
Interferometric Imaging ◽  
Mass Sensitivity ◽  
Interleukin 5 ◽  
Common Path ◽  
Rabbit Igg ◽  
Concentration Detection Limit

Abstract Molecular interferometric imaging (MI2) is a label-free optical biosensor that combines common-path interferometry with shot-noise limited characteristics of a CCD array detector to detect protein binding to surfaces. In the metrology limit, it has achieved roughness-limited surface height resolution of 15 pm per 0.4 micron pixel, corresponding to a scaling mass sensitivity of 7 fg/mm, and a molecular resolution of about 15 IgG molecules per pixel. We have applied MI2 to detect cytokine interleukin-5 at a concentration detection limit of 50 pg/mL with a sandwich immunoassay. Real-time binding assays with MI2 enable the study of reaction kinetics, with a scaling mass sensitivity of 2 pg/mm under 7x magnification. Real-time MI2 measurements of anti-rabbit IgG against rabbit IgG were compared with results from surface plasmon resonance, with identical association rate constants at 5x103 M-1sec-1.

Impedance spectroscopy based measurement system for quantitative and label-free real-time monitoring of tauopathy in hippocampal slice cultures

2012 ◽  
Vol 32 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Heinz-Georg Jahnke ◽  
Annett Braesigk ◽  
Till G.A. Mack ◽  
Sarah Pönick ◽  
Frank Striggow ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Real Time ◽  
Measurement System ◽  
Hippocampal Slice ◽  
Label Free ◽  
Real Time Monitoring ◽  
Hippocampal Slice Cultures

scholarly journals Optimization of a quantum weak measurement system with its working areas

2018 ◽  
Vol 26 (16) ◽  
pp. 21119 ◽  
Author(s):  
Yang Xu ◽  
Lixuan Shi ◽  
Tian Guan ◽  
Cuixia Guo ◽  
Dongmei Li ◽  
...  
Keyword(s):  
Measurement System ◽  
Weak Measurement

scholarly journals Rapid Separation of Enantiomeric Impurities in Chiral Molecules by a Self-Referential Weak Measurement System

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3788 ◽  
Author(s):  
Yang Xu ◽  
Lixuan Shi ◽  
Tian Guan ◽  
Suyi Zhong ◽  
Xuesi Zhou ◽  
...  
Keyword(s):  
Measurement System ◽  
Optical Rotation ◽  
Polarization State ◽  
Optical Resolution ◽  
Weak Measurement ◽  
Quarter Wave Plate ◽  
Chiral Molecules ◽  
Rapid Separation ◽  
Detection Scheme ◽  
Central Wavelength

We propose a self-referential fast detection scheme for a frequency domain weak measurement system for the detection of enantiomeric impurities in chiral molecules. In a transmissive weak measurement system, the optical rotation (OR) is used to modify the pre-selected polarization state and the post-selection polarization state. We obtained the sum and difference of the optical rotations produced by the sample and the standard by rotating the quarter wave plate in the system. Then, we estimate the ratio of chiral molecules to enantiomeric impurities using the ratio of the central wavelength shifts caused by the addition and subtraction states described above. In this paper, our system has an optical resolution of 1.88 × 10−5°. At the same time, we completed the detection of the ratio of the two substances in the mixture of L-proline and D-proline in different proportions, which proved that our system can quickly detect the content of enantiomeric impurities in chiral molecules.

Label-free electrical recognition of a dengue virus protein using the SEGFET simplified measurement system

2014 ◽  
Vol 6 (22) ◽  
pp. 8882-8885 ◽  
Author(s):  
Nirton C. S. Vieira ◽  
Alessandra Figueiredo ◽  
Juliana F. dos Santos ◽  
Ségio M. Aoki ◽  
Francisco E. G. Guimarães ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Measurement System ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Nonstructural Protein ◽  
Virus Protein ◽  
Label Free ◽  
Nonstructural Protein 1 ◽  
System P ◽  
Effect Transistor

Separative extended gate field-effect transistor was applied as an immunosensor for the label-free recognition of dengue virus nonstructural protein 1 (NS1).

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