scholarly journals Closed-loop wavefront sensing and correction in the mouse brain enabled by computed optical coherence microscopy

2021 ◽  
Author(s):  
Siyang Liu ◽  
Fei Xia ◽  
Xusan Yang ◽  
Meiqi Wu ◽  
Laurie Bizimana ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Closed Loop ◽  
Wavefront Sensing ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

scholarly journals 1700 nm optical coherence microscopy enables minimally invasive, label-free, in vivo optical biopsy deep in the mouse brain

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Jun Zhu ◽  
Hercules Rezende Freitas ◽  
Izumi Maezawa ◽  
Lee-way Jin ◽  
Vivek J. Srinivasan
Keyword(s):  
Minimally Invasive ◽  
Mouse Brain ◽  
Numerical Aperture ◽  
Optical Biopsy ◽  
Optical Coherence ◽  
Label Free ◽  
Optical Coherence Microscopy ◽  
Minimal Invasiveness ◽  
Cortical Regions

AbstractIn vivo, minimally invasive microscopy in deep cortical and sub-cortical regions of the mouse brain has been challenging. To address this challenge, we present an in vivo high numerical aperture optical coherence microscopy (OCM) approach that fully utilizes the water absorption window around 1700 nm, where ballistic attenuation in the brain is minimized. Key issues, including detector noise, excess light source noise, chromatic dispersion, and the resolution-speckle tradeoff, are analyzed and optimized. Imaging through a thinned-skull preparation that preserves intracranial space, we present volumetric imaging of cytoarchitecture and myeloarchitecture across the entire depth of the mouse neocortex, and some sub-cortical regions. In an Alzheimer’s disease model, we report that findings in superficial and deep cortical layers diverge, highlighting the importance of deep optical biopsy. Compared to other microscopic techniques, our 1700 nm OCM approach achieves a unique combination of intrinsic contrast, minimal invasiveness, and high resolution for deep brain imaging.

Wide-field optical coherence microscopy of the mouse brain slice

2015 ◽  
Vol 40 (19) ◽  
pp. 4420 ◽  
Author(s):  
Eunjung Min ◽  
Junwon Lee ◽  
Andrey Vavilin ◽  
Sunwoo Jung ◽  
Sungwon Shin ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Brain Slice ◽  
Wide Field ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

scholarly journals Imaging of the stroke-related changes in the vascular system of the mouse brain with the use of extended focus optical coherence microscopy

2016 ◽  
Author(s):  
Szymon Tamborski ◽  
Hong Chou Lyu ◽  
Danuta Bukowska ◽  
Hubert Dolezyczek ◽  
Grzegorz Wilczynski ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Vascular System ◽  
Optical Coherence ◽  
Optical Coherence Microscopy

scholarly journals Computed optical coherence microscopy of mouse brain ex vivo

2019 ◽  
Vol 24 (11) ◽  
pp. 1 ◽  
Author(s):  
Meiqi Wu ◽  
David M. Small ◽  
Nozomi Nishimura ◽  
Steven G. Adie
Keyword(s):  
Mouse Brain ◽  
Ex Vivo ◽  
Optical Coherence ◽  
Optical Coherence Microscopy
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