scholarly journals Effect of adipose tissue thickness and tissue optical properties on the differential pathlength factor estimation for NIRS studies on human skeletal muscle

2020 ◽  
Vol 12 (1) ◽  
pp. 571
Author(s):  
Ileana Pirovano ◽  
Simone Porcelli ◽  
Rebecca Re ◽  
Lorenzo Spinelli ◽  
Davide Contini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Optical Properties ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Tissue Thickness ◽  
Tissue Optical Properties ◽  
Factor Estimation

Adipose tissue thickness and optical properties affect differential pathlength factor in NIRS studies on human skeletal muscle

2021 ◽  
Author(s):  
Ileana Pirovano ◽  
Simone Porcelli ◽  
Rebecca Re ◽  
Lorenzo Spinelli ◽  
Davide Contini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Optical Properties ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Tissue Thickness

Adipose tissue thickness affects in vivo quantitative near-IR spectroscopy in human skeletal muscle

2001 ◽  
Vol 101 (1) ◽  
pp. 21 ◽  
Author(s):  
M.C.P. VAN BEEKVELT ◽  
M.S. BORGHUIS ◽  
B.G.M. VAN ENGELEN ◽  
R.A. WEVERS ◽  
W.N.J.M. COLIER
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Ir Spectroscopy ◽  
Human Skeletal Muscle ◽  
Tissue Thickness ◽  
Near Ir

Impact of Changes in Tissue Optical Properties on Near-Infrared Diffuse Correlation Spectroscopy Measures of Skeletal Muscle Blood Flow

2021 ◽  
Author(s):  
Miles F. Bartlett ◽  
Scott M. Jordan ◽  
Dennis M. Hueber ◽  
Michael D. Nelson
Keyword(s):  
Skeletal Muscle ◽  
Blood Flow ◽  
Optical Properties ◽  
Near Infrared ◽  
Muscle Blood Flow ◽  
Reactive Hyperemia ◽  
Correlation Spectroscopy ◽  
Skeletal Muscle Blood Flow ◽  
Diffuse Correlation Spectroscopy ◽  
Tissue Optical Properties

Near-infrared diffuse correlation spectroscopy (DCS) is increasingly utilized to study relative changes in skeletal muscle blood flow. However, most diffuse correlation spectrometers assume that tissue optical properties- such as absorption (μa) and reduced scattering (μ's) coefficients- remain constant during physiological provocations, which is untrue for skeletal muscle. Here, we interrogate how changes in tissue μa and μ's affect DCS calculations of blood flow index (BFI). We recalculated BFI using raw autocorrelation curves and μa/μ's values recorded during a reactive hyperemia protocol in 16 healthy young individuals. First, we show that incorrectly assuming baseline μa and μ's substantially affects peak BFI and BFI slope when expressed in absolute terms (cm2/s, p<0.01) but these differences are abolished when expressed in relative terms (% baseline). Next, to evaluate the impact of physiologic changes in μa and μ's, we compared peak BFI and BFI slope when μa and μ's were held constant throughout the reactive hyperemia protocol versus integrated from a 3s-rolling average. Regardless of approach, group means for peak BFI and BFI slope did not differ. Group means for peak BFI and BFI slope were also similar following ad absurdum analyses, where we simulated supraphysiologic changes in μa/μ's. In both cases, however, we identified individual cases where peak BFI and BFI slope were indeed affected, with this result being driven by relative changes in μa over μ's. Overall, these results provide support for past reports in which μa/μ's were held constant but also advocate for real-time incorporation of μa and μ's moving forward.

Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue

2007 ◽  
Vol 191 (3) ◽  
pp. 205-216 ◽  
Author(s):  
J. Gjedsted ◽  
L. C. Gormsen ◽  
S. Nielsen ◽  
O. Schmitz ◽  
C. B. Djurhuus ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Human Skeletal Muscle

Counterregulation in Peripheral Tissues: Effect of Systemic Hypoglycemia on Levels of Substrates and Catecholamines in Human Skeletal Muscle and Adipose Tissue

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. Tamborlane ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Peripheral Tissues

Counterregulation in peripheral tissues: effect of systemic hypoglycemia on levels of substrates and catecholamines in human skeletal muscle and adipose tissue

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. V. Tamborlane ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Peripheral Tissues

Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue

2003 ◽  
Vol 285 (2) ◽  
pp. E241-E251 ◽  
Author(s):  
Werner Regittnig ◽  
Martin Ellmerer ◽  
Günter Fauler ◽  
Gerald Sendlhofer ◽  
Zlatko Trajanoski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Human Subjects ◽  
Quadriceps Muscle ◽  
Model Parameters ◽  
Interstitial Glucose ◽  
Normal Human ◽  
Dynamic Relationships ◽  
Subcutaneous Adipose

We studied the kinetics of glucose exchange between plasma and interstitial fluid (ISF) in human skeletal muscle and adipose tissue under fasting conditions. Five normal human subjects received an intravenous [6,6-2H2]glucose infusion in a prime-continuous fashion. During the tracer infusion, the open-flow microperfusion technique was employed to frequently sample ISF from quadriceps muscle and subcutaneous adipose tissue. The tracer glucose kinetics observed in muscle and adipose tissue ISF were found to be well described by a capillary-tissue exchange model. As a measure of transcapillary glucose exchange efficiency, the 95% equilibrium time was calculated from the identified model parameters. This time constant was similar for skeletal muscle and adipose tissue (28.6 ± 3.2 vs. 26.8 ± 3.6 min; P = 0.60). Furthermore, we found that the (total) interstitial glucose concentration was significantly lower ( P < 0.01) in muscle (3.32 ± 0.46 mmol/l) and adipose tissue (3.51 ± 0.17 mmol/l) compared with arterialized plasma levels (5.56 ± 0.13 mmol/l). Thus the observed gradients and dynamic relationships between plasma and ISF glucose in muscle and adipose tissue provide evidence that transcapillary exchange of glucose is limited in these two tissues under fasting conditions.

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