Adipose tissue thickness and optical properties affect differential pathlength factor in NIRS studies on human skeletal muscle

2021 ◽  
Author(s):  
Ileana Pirovano ◽  
Simone Porcelli ◽  
Rebecca Re ◽  
Lorenzo Spinelli ◽  
Davide Contini ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Optical Properties ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Tissue Thickness

Adipose tissue thickness affects in vivo quantitative near-IR spectroscopy in human skeletal muscle

2001 ◽  
Vol 101 (1) ◽  
pp. 21 ◽  
Author(s):  
M.C.P. VAN BEEKVELT ◽  
M.S. BORGHUIS ◽  
B.G.M. VAN ENGELEN ◽  
R.A. WEVERS ◽  
W.N.J.M. COLIER
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Ir Spectroscopy ◽  
Human Skeletal Muscle ◽  
Tissue Thickness ◽  
Near Ir

Effects of a 3-day fast on regional lipid and glucose metabolism in human skeletal muscle and adipose tissue

2007 ◽  
Vol 191 (3) ◽  
pp. 205-216 ◽  
Author(s):  
J. Gjedsted ◽  
L. C. Gormsen ◽  
S. Nielsen ◽  
O. Schmitz ◽  
C. B. Djurhuus ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Glucose Metabolism ◽  
Human Skeletal Muscle

Counterregulation in Peripheral Tissues: Effect of Systemic Hypoglycemia on Levels of Substrates and Catecholamines in Human Skeletal Muscle and Adipose Tissue

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. Tamborlane ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Peripheral Tissues

Counterregulation in peripheral tissues: effect of systemic hypoglycemia on levels of substrates and catecholamines in human skeletal muscle and adipose tissue

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. V. Tamborlane ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Peripheral Tissues

Assessment of transcapillary glucose exchange in human skeletal muscle and adipose tissue

2003 ◽  
Vol 285 (2) ◽  
pp. E241-E251 ◽  
Author(s):  
Werner Regittnig ◽  
Martin Ellmerer ◽  
Günter Fauler ◽  
Gerald Sendlhofer ◽  
Zlatko Trajanoski ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Human Skeletal Muscle ◽  
Human Subjects ◽  
Quadriceps Muscle ◽  
Model Parameters ◽  
Interstitial Glucose ◽  
Normal Human ◽  
Dynamic Relationships ◽  
Subcutaneous Adipose

We studied the kinetics of glucose exchange between plasma and interstitial fluid (ISF) in human skeletal muscle and adipose tissue under fasting conditions. Five normal human subjects received an intravenous [6,6-2H2]glucose infusion in a prime-continuous fashion. During the tracer infusion, the open-flow microperfusion technique was employed to frequently sample ISF from quadriceps muscle and subcutaneous adipose tissue. The tracer glucose kinetics observed in muscle and adipose tissue ISF were found to be well described by a capillary-tissue exchange model. As a measure of transcapillary glucose exchange efficiency, the 95% equilibrium time was calculated from the identified model parameters. This time constant was similar for skeletal muscle and adipose tissue (28.6 ± 3.2 vs. 26.8 ± 3.6 min; P = 0.60). Furthermore, we found that the (total) interstitial glucose concentration was significantly lower ( P < 0.01) in muscle (3.32 ± 0.46 mmol/l) and adipose tissue (3.51 ± 0.17 mmol/l) compared with arterialized plasma levels (5.56 ± 0.13 mmol/l). Thus the observed gradients and dynamic relationships between plasma and ISF glucose in muscle and adipose tissue provide evidence that transcapillary exchange of glucose is limited in these two tissues under fasting conditions.

scholarly journals Noninvasive evaluation of skeletal muscle mitochondrial capacity with near-infrared spectroscopy: correcting for blood volume changes

2012 ◽  
Vol 113 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Terence E. Ryan ◽  
Melissa L. Erickson ◽  
Jared T. Brizendine ◽  
Hui-Ju Young ◽  
Kevin K. McCully
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Oxygen Consumption ◽  
Infrared Spectroscopy ◽  
Blood Volume ◽  
Near Infrared ◽  
Tissue Thickness ◽  
Volume Changes ◽  
Mitochondrial Capacity

Near-infrared spectroscopy (NIRS) is a well-known method used to measure muscle oxygenation and hemodynamics in vivo. The application of arterial occlusions allows for the assessment of muscle oxygen consumption (mV̇o2) using NIRS. The aim of this study was to measure skeletal muscle mitochondrial capacity using blood volume-corrected NIRS signals that represent oxygenated hemoglobin/myoglobin (O2Hb) and deoxygenated hemoglobin/myoglobin (HHb). We also assessed the reliability and reproducibility of NIRS measurements of resting oxygen consumption and mitochondrial capacity. Twenty-four subjects, including four with chronic spinal cord injury, were tested using either the vastus lateralis or gastrocnemius muscles. Ten healthy, able-bodied subjects were tested on two occasions within a period of 7 days to assess the reliability and reproducibility. NIRS signals were corrected for blood volume changes using three different methods. Resting oxygen consumption had a mean coefficient of variation (CV) of 2.4% (range 1–32%). The recovery of oxygen consumption (mV̇o2) after electrical stimulation at 4 Hz was fit to an exponential curve, which represents mitochondrial capacity. The time constant for the recovery of mV̇o2was reproducible with a mean CV of 10% (range 1–22%) only when correcting for blood volume changes. We also examined the effects of adipose tissue thickness on measurements of mV̇o2. We found the mV̇o2measurements using absolute units to be influenced by adipose tissue thickness (ATT), and this relationship was removed when an ischemic calibration was performed, supporting its use to compare mV̇o2between individuals of varying ATT. In conclusion, in vivo oxidative capacity can be assessed using blood volume-corrected NIRS signals with a high degree of reliability and reproducibility.

Sign in / Sign up

Export Citation Format

Share Document