Measurement of lipid composition in human skeletal muscle and adipose tissue with1H-MRS homonuclear spectral editing

2017 ◽  
Vol 79 (2) ◽  
pp. 619-627 ◽  
Author(s):  
Lucas Lindeboom ◽  
Robin A. de Graaf
2007 ◽  
Vol 191 (3) ◽  
pp. 205-216 ◽  
Author(s):  
J. Gjedsted ◽  
L. C. Gormsen ◽  
S. Nielsen ◽  
O. Schmitz ◽  
C. B. Djurhuus ◽  
...  

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. Tamborlane ◽  
...  

2021 ◽  
Author(s):  
Ileana Pirovano ◽  
Simone Porcelli ◽  
Rebecca Re ◽  
Lorenzo Spinelli ◽  
Davide Contini ◽  
...  

Diabetes ◽  
1997 ◽  
Vol 46 (1) ◽  
pp. 70-76 ◽  
Author(s):  
D. G. Maggs ◽  
R. Jacob ◽  
F. Rife ◽  
S. Caprio ◽  
W. V. Tamborlane ◽  
...  

2003 ◽  
Vol 285 (2) ◽  
pp. E241-E251 ◽  
Author(s):  
Werner Regittnig ◽  
Martin Ellmerer ◽  
Günter Fauler ◽  
Gerald Sendlhofer ◽  
Zlatko Trajanoski ◽  
...  

We studied the kinetics of glucose exchange between plasma and interstitial fluid (ISF) in human skeletal muscle and adipose tissue under fasting conditions. Five normal human subjects received an intravenous [6,6-2H2]glucose infusion in a prime-continuous fashion. During the tracer infusion, the open-flow microperfusion technique was employed to frequently sample ISF from quadriceps muscle and subcutaneous adipose tissue. The tracer glucose kinetics observed in muscle and adipose tissue ISF were found to be well described by a capillary-tissue exchange model. As a measure of transcapillary glucose exchange efficiency, the 95% equilibrium time was calculated from the identified model parameters. This time constant was similar for skeletal muscle and adipose tissue (28.6 ± 3.2 vs. 26.8 ± 3.6 min; P = 0.60). Furthermore, we found that the (total) interstitial glucose concentration was significantly lower ( P < 0.01) in muscle (3.32 ± 0.46 mmol/l) and adipose tissue (3.51 ± 0.17 mmol/l) compared with arterialized plasma levels (5.56 ± 0.13 mmol/l). Thus the observed gradients and dynamic relationships between plasma and ISF glucose in muscle and adipose tissue provide evidence that transcapillary exchange of glucose is limited in these two tissues under fasting conditions.


Diabetes ◽  
2009 ◽  
Vol 58 (10) ◽  
pp. 2402-2408 ◽  
Author(s):  
L. G. Grunnet ◽  
E. Nilsson ◽  
C. Ling ◽  
T. Hansen ◽  
O. Pedersen ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document