scholarly journals Evaluation of Doses-response and Combined Preventive Effects of Zinc and Vitamin D on Liver Toxicity Induced by Carbon Tetrachloride in Wistar Rats

2017 ◽  
Vol 5 (2) ◽  
pp. 46-52
Author(s):  
Serge D. Kone ◽  
Francis A. Yapo ◽  
Goue Gnahoue ◽  
Felix H. Yapi
Keyword(s):  
Vitamin D ◽  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Preventive Effects

Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar rats

2018 ◽  
Vol 17 (1) ◽  
pp. 1
Author(s):  
AbelNosereme Agbon ◽  
MustaphaTosin Issa ◽  
SadiyaUfeli Balogun ◽  
Onesimus Mahdi ◽  
KhadijatAbubakar Bobbo ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Hepatoprotective Effect ◽  
Fruit Pulp ◽  
Musa Paradisiaca

scholarly journals The protective effect of Vitamin D and combination with liv-52 on lipid profiles in carbon tetrachloride-induced liver disease in Wistar rats

2021 ◽  
Vol 12 (11) ◽  
pp. 71-78
Author(s):  
K. Ponnazhagan ◽  
J. Sivakumar ◽  
T. Gopalakrishnan
Keyword(s):  
Vitamin D ◽  
Liver Disease ◽  
Carbon Tetrachloride ◽  
Free Cholesterol ◽  
Wistar Rats ◽  
Total Body Weight ◽  
Well Being ◽  
The Body ◽  
Total Body ◽  
Exogenous Substances

Background: Liver is the largest gland, accounts for approximately 2.5% of total body weight and also liver called as the metabolic “engine-room of the body.” Liver plays role in both metabolism as well as biochemical transformation. Therefore, it is vital to maintain a healthy liver for overall health and well-being. However, liver is continuously exposed to exogenous substances such as toxins, drugs, and alcohol which can ultimately lead to various liver disorders. Liver diseases today are one of the most fatal diseases globally. Aims and Objectives: The aim of the present study was to evaluate lipid peroxidation (LPO) and lipid profile levels of Vitamin D and combination with Liv-52 on carbon tetrachloride induced liver disease in rats. Materials and Methods: Thirty-six adult male Albino Wistar rats weighing 150–200 g were used in this study. Liver disease was induced in rats by administration of Carbon tetrachloride (CCl4) intraperitoneally at the dose of 1 mL mixed with 50% of olive oil twice a week for 5 weeks, 3 days interval between each dose, after confirmation of liver disease treated with Vitamin D and Liv-52 for 5 weeks. Results: The levels of LPO were significantly decreased in Vitamin D and Liv-52 treated animals when compared with CCl4 induced animals. Total cholesterol, free cholesterol, phospholipids, and triglycerides (TGs) levels were significantly reduced when compared with CCl4 induced rats. However, the levels of ester cholesterol and free fatty acids (FFAs) were significantly increased in Vitamin D and Liv-52 treated animals when compared with CCl4 induced animals. Conclusion: Vitamin D and Liv-52 effectively reduced the LPO levels. Treatment with Vitamin D and Liv-52, the levels of total and free cholesterol, phospholipids, and TGs were significantly reduced and treatment with both combinations highly reduced all these levels when compared with CCl4 induced animals. And treatment with Vitamin D and Liv-52, the ester cholesterol and FFAs levels were increased.

scholarly journals Evaluation of Hepatoprotective effect of hydroalcoholic extract of Momordica Charantia leaves in carbon tetrachloride induced liver toxicity in Wistar rats

2019 ◽  
Vol 12 (3) ◽  
pp. 1555-1560
Author(s):  
Gurudatta Moharir ◽  
Ambadasu Bharatha ◽  
Nkemcho Ojeh ◽  
Vijay Prasad S
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Liver Toxicity ◽  
Liquid Paraffin ◽  
Modern Medicine ◽  
Momordica Charantia ◽  
Control Group ◽  
Group V ◽  
Group I

Liver carries out a variety of physiological functions and protects against damaging drugs and chemicals. Herbs have been shown to play a major role in the management of various liver disorders. Due to the lack of effective liver protective medication in modern medicine, several herbal options for the treatment of liver diseases in Ayurveda are suggested. In this current study, we evaluated the hepatoprotective action of Momordica charantia leaf extract in comparison to Liv-52, a standard hepatoprotective drug. In Wistar rats, hepatotoxicity was induced by administering carbon tetrachloride (CCl4) 1ml / kg body weight subcutaneously on alternate days for a week in a suspension of liquid paraffin. Rats were grouped into 5 groups with group I as control, group II - CCl4 treatment only, group III receiving a mixture of Liv-52 orally (5 ml / kg) and CCl4, and group IV and group V receiving Momordica charantia leaf extract administered orally to rats at doses of 100 and 200 mg / kg respectively, together with CCl4 for 1 week.. Indices of liver functions (lipid profile) were evaluated in the serum of the rats. Animals were sacrificed after the study period and liver tissue was isolated for histopathological changes. The mean results for groups I to V for SGOT levels in IU/L were: 53.57 ± 1.19, 167.72 ± 5.57, 54.72 ± 0.83, 69.41 ± 2.35 and 60.72 ± 1.5 respectively; for SGPT in IU/L were 37.00 ± 1.77, 118.16 ± 2.91, 61.41 ± 1.25, 47.92 ± 1.71 and 58.59 ± 1.81 respectively; for ALP in IU/L were 165.44 ± 4.84, 281.33 ± 7.11, 206 ± 6.95, 190.62±5.47 and 188.86 ± 2.5 respectively and for total bilirubin levels in mg/dl were 0.71± 0.66, 1.57 ± 0.1, 0.80 ± 0.20.88 ± 0.02 & 0.77 ± 0.03 respectively. The findings from this study showed a decrease in the liver enzymes and therefore suggests protective activity of Momordica charantia leaf extract against CCl4 induced hepatic toxicity.

scholarly journals Hepatoprotective effect of galangin on carbon tetrachloride-induced hepatotoxicity via the LKB1/AMPK pathway

2021 ◽  
Vol 19 ◽  
pp. 205873922110008
Author(s):  
Meng Chen ◽  
Xinyan Song ◽  
Jifang Jiang ◽  
Lei Xing ◽  
Pengfei Wang
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Toxicity ◽  
Corn Oil ◽  
Histopathological Examination ◽  
Hepatoprotective Effect ◽  
Control Group ◽  
Group Model ◽  
Protective Effects ◽  
Model Group ◽  
Expression Levels

To investigate the protective effects of galangin on liver toxicity induced by carbon tetrachloride (CCl4) in mice. Mouse hepatotoxicity model was established by intraperitoneal injection (i.p.) of 10 ml/kg body weight CCl4 that diluted with corn oil to a proportion of 1:500 on Kunming mice. The mice were randomly divided into five groups named control group, model group, and 1, 5, and 10 mg/kg galangin group. The levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed by ELISA. Liver histopathological examination was observed via optical microscopy. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), and glutathion (GSSG) were analyzed to assess oxidative stress. Finally, western blot assay was carried out to analyse the expression levels of total AMP-activated protein kinase (AMPK), phospho-AMPK (p-AMPK), total liver kinase B1 (LKB1), and phospho-LKB1 (p-LKB1). Compared with the control group, in the model group, the levels of AST, ALT, MDA, and GSSG increased significantly ( p < 0.01); the activity of SOD and GSH decreased significantly ( p < 0.01); and the histopathological examination revealed liver necrosis. However, treatment with galangin (5 and 10 mg/kg) significantly reversed these CCl4-induced liver damage indicators. Furthermore, treatment with galangin (10 mg/kg) significantly increased the p-AMPK and p-LKB1 expression levels ( p < 0.01). This study supports the hepatoprotective effect of galangin against hepatotoxicity, perhaps occurring mainly through the LKB1/AMPK-mediated pathway.

scholarly journals The Preventive Effects of Cynara scolymus Leaf and Flower Extracts on Diethylnitrosamine/ Acetylaminoflourene Induced Nephrotoxicity in Male Wistar Rats

2020 ◽  
Vol 8 (s2) ◽  
Author(s):  
Lamiaa Nabil Bakry ◽  
Abeer Mohamed Abd El-Hameed ◽  
Sanaa Mahmoud Abd El-Twab ◽  
Osama Mohamed Ahmed ◽  
Adel Abel-Moneim
Keyword(s):  
Wistar Rats ◽  
Cynara Scolymus ◽  
Male Wistar Rats ◽  
Preventive Effects
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