scholarly journals Hepatoprotective activity of methanolic shoot extract of Bambusa bambos against carbon tetrachloride induce acute liver toxicity in Wistar rats

2018 ◽  
pp. 37-40
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Hepatoprotective Activity

scholarly journals HEPATOPROTECTIVE ACTIVITY OF CORDIA OBLIQUA AGAINST PARACETAMOL-INDUCED LIVER TOXICITY ON WISTAR RATS

2019 ◽  
pp. 149-152
Author(s):  
SIVAKRISHNAN SIVAGNANAM ◽  
PRADEEPRAJ DEVARASU
Keyword(s):  
Wistar Rats ◽  
Liver Toxicity ◽  
Histological Study ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Plant Materials ◽  
Percolation Method ◽  
Soxhlet Apparatus ◽  
Serum Glutamate Pyruvate Transaminase

Objective: The ethanolic extract of Cordia obliqua (EECO) Willd. leaves was evaluated for hepatoprotective activity in Wistar rats by inducing hepatic damage with paracetamol. Methods: The leaves of C. obliqua were dried under shade, segregated, pulverized by a mechanical grinder and passed through a 40 mesh sieve. The powdered plant materials were stored in an air-tight container. The above-powdered materials were successively extracted with ethanol by hot continuous percolation method in Soxhlet apparatus for 24 h. The extract was concentrated using a rotary evaporator and subjected to freeze drying in a lyophilizer till dry powder was obtained. Results: Treatment with EECO at 200 and 400 mg/kg showed significant decrease in serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, and total bilirubin levels and a significant elevation in the total protein, albumin, and globulin levels in serum when compared with paracetamol treated rats. In histological study of liver, the hepatocytes show moderate cytoplasm and moderately enlarged pleomorphic and hyperchromatic nuclei. The portal triads show mild periportal inflammation composed of lymphocytes, and central veins are normal. Conclusion: On the basis of results, we can conclude that the EECO leaves showed potential hepatoprotective activity in rats.

scholarly journals Phytochemical Characterization, Hepatoprotective Activity on Alcohol-Induced Toxicity of the Aqueous Extract of Curcuma longa (Zingiberaceae) in Wistar Rats

2021 ◽  
pp. 134-149
Author(s):  
Ameaka Fatima Nkempu ◽  
Tembe Estella ◽  
Tchadji Mayoudom Vanessa Edwige ◽  
Bayaga Herve ◽  
Dobgima John Fonmboh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Secondary Metabolites ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Curcuma Longa ◽  
Hepatoprotective Activity ◽  
Bioactive Metabolites ◽  
Central Vein ◽  
Phytochemical Screening

Introduction: Liver or hepatic disease refers to different conditions that affect the liver. Chronic alcohol consumption is one of the most frequent causes of liver disease and accounts for about 55% of liver cirrhosis deaths recorded in Cameroon in 2020. Standard accessible treatments focus on end-stage liver disease with safety and efficacy obstacles. We have a research gap in Cameroon to understand the alternative use of natural products as treatment with a long traditional history of safe use. Curcuma longa has long been a source of traditional and modern medicine. It is commonly used in Cameroon as a spice and herbal product with some level of activity against various forms of liver disease. Objective: To phytochemically screen for bioactive metabolites and evaluate the hepatoprotective activity of the aqueous extract of Curcuma longaon alcohol-induced toxicity in Wistar rats. Methods: Phytochemical screening was carried out on the aqueous extract obtainedfrom maceration of plant rhizomes. Three doses (125, 250 and 500mg/Kg) of the plant extract and the reference (Silymarin 50mg/Kg) were administered daily (p.o) to rats 30 min before administration of 40% alcohol (2mL/100g p.o) for 21 days. Biochemical parameters such as ALAT, ASAT, GGT, Bilirubin and Lipid profile were quantified and histological studies of the liverwas carried out using standard procedures. Results: Phytochemical screening of the aqueous extract of C. longa revealed polyphenols such as flavonoids, tannins, quinones, saponins and phlobatanins. The plant showed hepatoprotective activity by decreasing liver toxicity markers such as ASAT, ALAT, GGT and Bilirubin. Histology revealed dose-dependent protection with 500 mg/Kg showing the most cellular integrity, no central vein occlusion and minimal fibrosis. Conclusion: This study indicated the presence of polyphenols like flavonoids and tannins in the aqueous extract of C. longa. The presence of these secondary metabolites in the studied extract justifies its antioxidant and anti-inflammatory properties confirmed by its hepatoprotective effects on alcohol-induced toxicity. This was clearly shown by biochemical and histological parameters. More sensitive and specific methods are required to test for these secondary metabolites in serum.

Hepatoprotective effect of methanol fruit pulp extract of Musa paradisiaca on carbon tetrachloride-induced liver toxicity in Wistar rats

2018 ◽  
Vol 17 (1) ◽  
pp. 1
Author(s):  
AbelNosereme Agbon ◽  
MustaphaTosin Issa ◽  
SadiyaUfeli Balogun ◽  
Onesimus Mahdi ◽  
KhadijatAbubakar Bobbo ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Liver Toxicity ◽  
Hepatoprotective Effect ◽  
Fruit Pulp ◽  
Musa Paradisiaca

scholarly journals Evaluation of Hepatoprotective effect of hydroalcoholic extract of Momordica Charantia leaves in carbon tetrachloride induced liver toxicity in Wistar rats

2019 ◽  
Vol 12 (3) ◽  
pp. 1555-1560
Author(s):  
Gurudatta Moharir ◽  
Ambadasu Bharatha ◽  
Nkemcho Ojeh ◽  
Vijay Prasad S
Keyword(s):  
Carbon Tetrachloride ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Liver Toxicity ◽  
Liquid Paraffin ◽  
Modern Medicine ◽  
Momordica Charantia ◽  
Control Group ◽  
Group V ◽  
Group I

Liver carries out a variety of physiological functions and protects against damaging drugs and chemicals. Herbs have been shown to play a major role in the management of various liver disorders. Due to the lack of effective liver protective medication in modern medicine, several herbal options for the treatment of liver diseases in Ayurveda are suggested. In this current study, we evaluated the hepatoprotective action of Momordica charantia leaf extract in comparison to Liv-52, a standard hepatoprotective drug. In Wistar rats, hepatotoxicity was induced by administering carbon tetrachloride (CCl4) 1ml / kg body weight subcutaneously on alternate days for a week in a suspension of liquid paraffin. Rats were grouped into 5 groups with group I as control, group II - CCl4 treatment only, group III receiving a mixture of Liv-52 orally (5 ml / kg) and CCl4, and group IV and group V receiving Momordica charantia leaf extract administered orally to rats at doses of 100 and 200 mg / kg respectively, together with CCl4 for 1 week.. Indices of liver functions (lipid profile) were evaluated in the serum of the rats. Animals were sacrificed after the study period and liver tissue was isolated for histopathological changes. The mean results for groups I to V for SGOT levels in IU/L were: 53.57 ± 1.19, 167.72 ± 5.57, 54.72 ± 0.83, 69.41 ± 2.35 and 60.72 ± 1.5 respectively; for SGPT in IU/L were 37.00 ± 1.77, 118.16 ± 2.91, 61.41 ± 1.25, 47.92 ± 1.71 and 58.59 ± 1.81 respectively; for ALP in IU/L were 165.44 ± 4.84, 281.33 ± 7.11, 206 ± 6.95, 190.62±5.47 and 188.86 ± 2.5 respectively and for total bilirubin levels in mg/dl were 0.71± 0.66, 1.57 ± 0.1, 0.80 ± 0.20.88 ± 0.02 & 0.77 ± 0.03 respectively. The findings from this study showed a decrease in the liver enzymes and therefore suggests protective activity of Momordica charantia leaf extract against CCl4 induced hepatic toxicity.

scholarly journals Hepatoprotective Activity of Hydroalcohilic Extract of Annona squamosa Seeds

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Shuchi Dave Mehta ◽  
Sarvesh Paliwal
Keyword(s):  
Carbon Tetrachloride ◽  
Total Bilirubin ◽  
Liver Toxicity ◽  
Liver Function Tests ◽  
Hepatoprotective Activity ◽  
Control Group ◽  
Annona Squamosa ◽  
Microbial Infection ◽  
Related Disorder ◽  
Hydroalcoholic Extract

Ethnopharmacological Relevance: Traditionally, Annona Sqamosa Linn. has been used for treatment of cancer, diabetes, microbial infection, cardiac disease, jaundice and other liver related disorder. Hence the current work aims to explore the hepatoprotective of the Annona Sqamosa (AS) seeds. Aim of the study: The main objective of study is to evaluate hepatoprotective activity of the hydroalcoholic extract of seeds of Annona Squamosa Linn. using the carbon tetrachloride induced liver toxicity in rats. Material and methods: The activity was evaluated against carbon tetrachloride induced hepatotoxicity by measuring the levels of serum enzymes such as SGOT, ALP, SGPT and total bilirubin for liver function tests. Six groups of rats were used (n=6) and administered orally once daily with normal saline (normal control), carbon tetrachloride (toxic control), or ASE (100, 200, and 400 mg/kg) for 7 days, followed by the hepatotoxicity induction. Results: The extract showed significant hepatoprotective activity at 100 mg/kg, 200 mg/kg, and 400mg /kg b.w by decreasing the levels of SGOT, SGPT, ALP and total bilirubin as compared to toxic control group. Conclusions: The hydroalcoholic ASE extract have potential of liver protection which could be attributed for further investigation

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