THE IMPACT OF INTERRUPTIONS IN HYPERBARIC OXYGEN EXPOSURES ON THE DEVELOPMENT OF OXYGEN TOXICITY IN RATS

2014 ◽  
Author(s):  
Bohdan Łokucijewski ◽  
Tadeusz Doboszyński
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Toxicity ◽  
The Impact

Hyperoxic myopia: a case series of four divers

2020 ◽  
pp. 261-265
Author(s):  
Jonathan W. Brügger ◽  
Glenn A. Rauscher ◽  
John P. Florian ◽  
Keyword(s):  
Hyperbaric Oxygen ◽  
Prolonged Exposure ◽  
Case Series ◽  
Oxygen Toxicity ◽  
Hyperbaric Oxygen Treatment ◽  
Subjective Data ◽  
Residual Symptoms ◽  
Oxygen Treatment ◽  
Blurry Vision ◽  
Record Review

Hyperoxic myopia is a phenomenon reported in individuals who have prolonged exposure to an increased partial pressure of oxygen (PO2) and subsequently have a myopic (nearsighted) change in their vision. To date, there are numerous accounts of hyperoxic myopia in dry hyperbaric oxygen treatment patients; however, there have been only three confirmed cases reported in wet divers. This case series adds four confirmed cases of hyperoxic myopia in wet divers using 1.35 atmospheres (ATM) PO2 at the Navy Experimental Diving Unit (NEDU). The four divers involved were the first author’s patients at NEDU. Conditions for two divers were confirmed via record review, whereas the other two divers were diagnosed by the first author. All subjects were interviewed to correlate subjective data with objective findings. Each subject completed five consecutive six-hour hyperoxic (PO2 of 1.35 ATM) dives with 18-hour surface intervals. Each individual was within the U. S. Navy Dive Manual’s standards for general health. Visual acuity was measured prior to diving. Within three to four days after diving, the individuals reported blurry vision with an associated myopic refraction shift. Each diver had spontaneous resolution of his myopia over the next two to three weeks, with no significant residual symptoms. The divers in this case series were exposed to an increased PO2 (1.35 ATM for 30 hours over five days), a lesser exposure than that in other reports of hyperoxic myopia in wet divers diagnosed with hyperoxic myopia (1.3-1.6 ATM for 45-85 hours in 12-18 days). Furthermore, this pulse of exposure was more concentrated than typically seen with traditional hyperbaric oxygen therapy. Hyperoxic myopia continues to be a risk for those conducting intensive diving with a PO2 between 1.3-1.6 ATM. Additional investigation is warranted to better define risk factors and PO2 limits regarding ocular oxygen toxicity.

Succinate: Protective Agent against Hyperbaric Oxygen Toxicity

Science ◽  
1965 ◽  
Vol 150 (3705) ◽  
pp. 1830-1831 ◽  
Author(s):  
A. P. Sanders ◽  
I. H. Hall ◽  
B. Woodhall
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Toxicity ◽  
Protective Agent

Modification of hyperbaric oxygen toxicity by experimental venous admixture.

1967 ◽  
Vol 23 (6) ◽  
pp. 954-963 ◽  
Author(s):  
P M Winter ◽  
R K Gupta ◽  
A H Michalski ◽  
E H Lanphier
Keyword(s):  
Hyperbaric Oxygen ◽  
Oxygen Toxicity ◽  
Venous Admixture

scholarly journals The Impact of Hyperbaric Oxygen Therapy on Serum C-Reactive Protein Levels, Osteoprotegerin Expression, and Osteoclast Numbers in Induced-Periodontitis Diabetic Rats

2020 ◽  
Vol 14 (03) ◽  
pp. 404-409
Author(s):  
Dian Mulawarmanti ◽  
Kristanti Parisihni ◽  
Widyastuti Widyastuti
Keyword(s):  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Serum Crp ◽  
The Impact

Abstract Objectives This study aimed to examine the impact of hyperbaric oxygen therapy (HBOT) on serum C-reactive protein (CRP) levels, osteoclast numbers, and osteoprotegerin (OPG) expression in periodontitis-induced diabetic rats Materials and Methods This study constituted an in vivo laboratory-based experiment incorporating a posttest only control group design. Thirty male Wistar rats were divided into three groups of research subjects: a healthy group (K0), periodontitis-induced diabetic group (K1), and periodontitis-induced diabetic group treated with HBOT for 7 days (K2). After treatment, the subjects were sacrificed to determine the level of serum CRP by the ELISA method. Immunohistochemical analysis was conducted to check the level of OPG expression, while a histological analysis was undertaken to quantify the number of osteoclasts. Statistical Analysis The data was analyzed using a one-way ANOVA and Least Significant Difference (LSD) test on which a result of p < 0.05 was considered statistically significant. Results HBOT appreciably decreased serum CRP levels, significantly enhancing OPG expression in periodontitis-induced diabetic (p < 0.05) and decreasing the number of osteoclasts in -periodontitis-induced diabetic (p > 0.05). Conclusion HBOT reduced the serum CRP level, increased OPG expression, and decreased osteoclast numbers in periodontitis-induced diabetic rats.

scholarly journals Sudden death after oxygen toxicity seizure during hyperbaric oxygen treatment: Case report

2020 ◽  
Vol 50 (2) ◽  
pp. 185-188
Author(s):  
Rutger C Lalieu ◽  
◽  
René D Bol Raap ◽  
Emile FL Dubois ◽  
Rob A van Hulst ◽  
...  
Keyword(s):  
Case Report ◽  
Sudden Death ◽  
Hyperbaric Oxygen ◽  
Oxygen Toxicity ◽  
Hyperbaric Oxygen Treatment ◽  
Oxygen Treatment

scholarly journals Seizures Caused by Exposure to Hyperbaric Oxygen in Rats Can Be Predicted by Early Changes in Electrodermal Activity

2022 ◽  
Vol 12 ◽  
Author(s):  
Hugo F. Posada-Quintero ◽  
Carol S. Landon ◽  
Nicole M. Stavitzski ◽  
Jay B. Dean ◽  
Ki H. Chon
Keyword(s):  
Nervous System ◽  
Hyperbaric Oxygen ◽  
Electrodermal Activity ◽  
Radio Telemetry ◽  
Core Body Temperature ◽  
Ambient Pressure ◽  
Oxygen Toxicity ◽  
Hyperbaric Chamber ◽  
Generalized Seizures ◽  
Animal Chamber

Hyperbaric oxygen (HBO2) is breathed during undersea operations and in hyperbaric medicine. However, breathing HBO2 by divers and patients increases the risk of central nervous system oxygen toxicity (CNS-OT), which ultimately manifests as sympathetic stimulation producing tachycardia and hypertension, hyperventilation, and ultimately generalized seizures and cardiogenic pulmonary edema. In this study, we have tested the hypothesis that changes in electrodermal activity (EDA), a measure of sympathetic nervous system activation, precedes seizures in rats breathing 5 atmospheres absolute (ATA) HBO2. Radio telemetry and a rodent tether apparatus were adapted for use inside a sealed hyperbaric chamber. The tethered rat was free to move inside a ventilated animal chamber that was flushed with air or 100% O2. The animal chamber and hyperbaric chamber (air) were pressurized in parallel at ~1 atmosphere/min. EDA activity was recorded simultaneously with cortical electroencephalogram (EEG) activity, core body temperature, and ambient pressure. We have captured the dynamics of EDA using time-varying spectral analysis of raw EDA (TVSymp), previously developed as a tool for sympathetic tone assessment in humans, adjusted to detect the dynamic changes of EDA in rats that occur prior to onset of CNS-OT seizures. The results show that a significant increase in the amplitude of TVSymp values derived from EDA recordings occurs on average (±SD) 1.9 ± 1.6 min before HBO2-induced seizures. These results, if corroborated in humans, support the use of changes in TVSymp activity as an early “physio-marker” of impending and potentially fatal seizures in divers and patients.

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