scholarly journals Artonin O, a Xanthone Compound from Root Wood of Artocarpus Rigida

2016 ◽  
Vol 32 (5) ◽  
pp. 2777-2784 ◽  
Author(s):  
Tati Suhartati ◽  
Ajeng Wulandari ◽  
Jhond Suwandi ◽  
Yandri Yandri ◽  
Sutopo Hadi
Keyword(s):  
Xanthone Compound

Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E-deficient mice

2008 ◽  
Vol 86 (12) ◽  
pp. 815-826 ◽  
Author(s):  
Hong-Bo Xiao ◽  
Zhi-Liang Sun ◽  
Xiang-Yang Lu ◽  
Da-Zhi Li ◽  
Jian-Ping Xu ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Apolipoprotein E ◽  
Density Lipoprotein ◽  
Control Group ◽  
Elevated Expression ◽  
Plasma High Density ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Xanthone Compound

Previous investigations have shown that decreased expression of angiopoietin-like protein 3 (Angptl3) is protective against dyslipidemia in atherosclerosis. The present study was conducted to test the effect of 3,4,5,6-tetrahydroxyxanthone, a xanthone compound, on dyslipidemia in apolipoprotein E-deficient (ApoE−/−) mice. Forty mice were randomly divided into 4 groups (n = 10): control group (C57BL/6J mice), ApoE−/− mice group, and two groups of ApoE−/− mice treated with 3,4,5,6-tetrahydroxyxanthone (10 or 30 mg/kg per day). Eight weeks after treatment, lipid levels in the blood and liver, expression of hepatic Angptl3, and adipose tissue lipoprotein lipase (LPL) were determined. Treatment with 3,4,5,6-tetrahydroxyxanthone (10 or 30 mg/kg) significantly decreased plasma and hepatic total cholesterol and triglyceride concentrations, increased plasma high-density lipoprotein cholesterol, and significantly downregulated expression of Angptl3 mRNA and protein concomitantly with upregulated expression of LPL mRNA. In addition, T0901317 (a liver X receptor ligand) caused elevated expression of hepatic Angptl3 mRNA and protein, and the effect of T0901317 was also abrogated by 3,4,5,6-tetrahydroxyxanthone in vivo and in vitro. The present results suggest that the beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia may be related to reduced expression of Angptl3.

4-(1,1-Dimethylprop-2-enyl)-1,3,5,6-tetrahydroxy-2-(3-methylbut-2-enyl)-9H-xanthen-9-one monohydrate

2006 ◽  
Vol 62 (5) ◽  
pp. o2034-o2036 ◽  
Author(s):  
Nawong Boonnak ◽  
Suchada Chantrapromma ◽  
Hoong-Kun Fun
Keyword(s):  
Crystal Structure ◽  
Benzene Ring ◽  
Intermolecular Interactions ◽  
Title Compound ◽  
Side Chains ◽  
Π Interactions ◽  
Compound C ◽  
Xanthone Compound

The title compound, C23H24O6·H2O, a xanthone compound, was isolated from Cratoxylum formosum ssp. pruniflorum. The three rings in the molecule are coplanar. The 3-methylbut-2-enyl and 1,1-dimethylprop-2-enyl side chains are axially attached to the benzene ring. There are intra- and intermolecular O—H...O and C—H...O interactions. The crystal structure is stabilized by these intermolecular interactions as well by C—H...π interactions.

A new xanthone compound fromCentaurium erythraea

1983 ◽  
Vol 19 (1) ◽  
pp. 105-105 ◽  
Author(s):  
N. M. Neshta ◽  
V. I. Glyzin ◽  
G. G. Nikolaeva ◽  
V. I. Sheichenko
Keyword(s):  
Xanthone Compound

scholarly journals Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]

2015 ◽  
pp. 3001
Author(s):  
Mohamed Yousif Ibrahim ◽  
Hapipah Mohd Ali ◽  
Najihah Binti Mohd Hashim ◽  
Mohan Syam ◽  
Siddig Ibrahim Abdelwahab ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Nf Kappa B ◽  
Prenylated Xanthone ◽  
Xanthone Compound

Involvement of NF-κB and Bcl2/Bax signaling pathways in the apoptosis of MCF7 cells induced by a xanthone compound Pyranocycloartobiloxanthone A

Phytomedicine ◽  
2012 ◽  
Vol 19 (11) ◽  
pp. 1007-1015 ◽  
Author(s):  
Syam Mohan ◽  
Siddig Ibrahim Abdelwahab ◽  
Behnam Kamalidehghan ◽  
Suvitha Syam ◽  
Koh Sue May ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Mcf7 Cells ◽  
Xanthone Compound

A new xanthone compound fromCentaurium erythraea. III

1983 ◽  
Vol 19 (6) ◽  
pp. 750-751 ◽  
Author(s):  
N. M. Neshta ◽  
V. I. Glyzin ◽  
A. A. Savina ◽  
A. V. Patudin
Keyword(s):  
Xanthone Compound

A new xanthone compound fromCentaurium erythraea. IV

1984 ◽  
Vol 20 (1) ◽  
pp. 108-108 ◽  
Author(s):  
N. M. Neshta ◽  
V. I. Glyzin ◽  
A. V. Patudin
Keyword(s):  
Xanthone Compound

scholarly journals Anti-oxidant and anti-bacterial activities of 11 Calophyllum species from Indonesia

2019 ◽  
Vol 1 (2) ◽  
pp. 1-12
Author(s):  
Jamilah Abbas
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Bacillus Subtilis ◽  
Radical Scavenging ◽  
Stem Bark ◽  
Bacterial Activity ◽  
Extraction And Separation ◽  
Anti Oxidant ◽  
Xanthone Compound

Members of Calophyllum (Calophyllaceae) are commonly used as herbal medicine in Indonesia from the beginning of civilization. Due to their tremendous potential as a source for pharmaceutical industry, we selected 11 Calophyllum species for the current anti-oxidant and anti-bacterial studies, namely, Calophyllum euryphyllum, C. bicolor, C. flavoramulum, C incrassaptum, C. lowei, C. macrophyllum, C. nodosum, C. soulattri, C. tetrapterum, C. teysmannii, and C. tomentosum. The methods include Calophyllum stem bark extraction and separation into n-hexane, ethyl acetate, and butanol fractions, followed by the antioxidant analysis using DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging) and the anti-bacterial activity against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. The results showed that n-hexane fraction of C. soulattri exhibited the best anti-oxidant activity (IC50 = 2.2 µg/m). This study also showed that a xanthone compound isolated from C. macrophyllum, namely, 1,8 - dihydroxy-6 methoxy xanthone exhibited the anti-oxidant activity with IC50 = 1.56 ppm.

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