scholarly journals Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Corrigendum]

2015 ◽  
pp. 3001
Author(s):  
Mohamed Yousif Ibrahim ◽  
Hapipah Mohd Ali ◽  
Najihah Binti Mohd Hashim ◽  
Mohan Syam ◽  
Siddig Ibrahim Abdelwahab ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Nf Kappa B ◽  
Prenylated Xanthone ◽  
Xanthone Compound

scholarly journals Involvement of NF-ΚB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens

2014 ◽  
pp. 2193 ◽  
Author(s):  
Mohamed Yousif Ibrahim ◽  
Hapipah Mohd Ali ◽  
Najihah Mohd Hashim ◽  
Syam Mohan ◽  
Siddig Ibrahim Abdelwahab ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Nf Kappa B ◽  
Prenylated Xanthone ◽  
Xanthone Compound

scholarly journals Involvement of NF-κB and HSP70 signaling pathways in the apoptosis of MDA-MB-231 cells induced by a prenylated xanthone compound, α-mangostin, from Cratoxylum arborescens [Retraction]

2017 ◽  
Vol Volume 11 ◽  
pp. 1399-1400 ◽  
Author(s):  
Mohamed Yousif Ibrahim ◽  
Najihah Mohd Hashim ◽  
Syam Mohan ◽  
Mahmood A Abdulla ◽  
Siddig I Abdelwahab ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Nf Kappa B ◽  
Prenylated Xanthone ◽  
Xanthone Compound

scholarly journals Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus

2021 ◽  
Author(s):  
Chun Li ◽  
Cong Feng ◽  
Guangyuan Ma ◽  
Shaoyin Fu ◽  
Ming Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Expression Patterns ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Receptor Interaction ◽  
Morphological Evidence ◽  
Gene Expression Patterns ◽  
Growth Stages ◽  
Nf Kappa B

Abstract Background Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes in the natural photoperiod. Although several studies have compared and analyzed the differences in gene expression between different cashmere growth stages, the selection of samples in these studies relies on research experience or morphological evidence. Distinguishing cashmere growth cycle according to gene expression patterns may help to explore the regulation mechanisms related to cashmere growth and the effect of melatonin from a molecular level more accurately. Results In this study, we applied RNA-sequencing to the hair follicles of three normal and three melatonin-treated Inner Mongolian cashmere goats sampled every month during a whole cashmere growth cycle. A total of 3559 and 988 genes were subjected as seasonal changing genes (SCGs) in the control and treated groups, respectively. The SCGs in the normal group are divided into three clusters, and their specific expression patterns help to group the cashmere growth cycle into anagen, catagen and telogen stages. Some canonical pathways such as Wnt, TGF-beta and Hippo signaling pathways are detected as promoting the cashmere growth, while Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Jak-STAT, Fc epsilon RI, NOD-like receptor, Rap1, PI3K-Akt, cAMP, NF-kappa B and many immune-related pathways are detected in the catagen and telogen stages. The PI3K-Akt signaling, ECM-receptor interaction and Focal adhesion are found in the transition stage between telogen to anagen, which may serve as candidate biomarkers for telogen-anagen regeneration. Pairwise comparisons between the control and melatonin-treated groups also indicate 941 monthly differentially expressed genes (monthly DEGs). These monthly DEGs are mainly distributed from April and September, which reveal a potential signal pathway map regulating the anagen stage triggered by melatonin. Enrichment analysis shows that Wnt, Hedgehog, ECM, Chemokines and NF-kappa B signaling pathways may be involved in the regulation of non-quiescence and secondary shedding under the influence of melatonin. Conclusions Our study decodes the key regulators of the whole cashmere growth cycle, laying the foundation for the control of cashmere growth and improvement of cashmere yield.

scholarly journals Angiotensin II Upregulates Endothelial Lipase Expression via the NF-Kappa B and MAPK Signaling Pathways

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107634 ◽  
Author(s):  
Xiaoli Zhang ◽  
Minghui Wu ◽  
Hong Jiang ◽  
Jing Hao ◽  
Qingli Zhang ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Signaling Pathways ◽  
Mapk Signaling ◽  
Endothelial Lipase ◽  
Nf Kappa B ◽  
Mapk Signaling Pathways ◽  
Lipase Expression

scholarly journals Asiatic acid ameliorates CC l4-induced liver fibrosis in rats: involvement of Nrf2/ARE, NF-κB/IκBα, and JAK1/STAT3 signaling pathways

2018 ◽  
Vol Volume 12 ◽  
pp. 3595-3605 ◽  
Author(s):  
Jie Fan ◽  
Qingshan Chen ◽  
Liwen Wei ◽  
Xiaoming Zhou ◽  
Rong Wang ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Signaling Pathways ◽  
Asiatic Acid ◽  
Nf Kappa B ◽  
I Kappa B Alpha ◽  
Stat3 Signaling
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