scholarly journals Treadmill exercise alleviates prenatal noise stress-induced impairment of spatial learning ability through enhancing hippocampal neurogenesis in rat pups

2013 ◽  
Vol 9 (5) ◽  
pp. 451-456 ◽  
Author(s):  
Tae-Woon Kim ◽  
Mal-Soon Shin ◽  
Joon-Ki Park ◽  
Mi-Ai Shin ◽  
Hee-Hyuk Lee ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Treadmill Exercise ◽  
Hippocampal Neurogenesis ◽  
Learning Ability ◽  
Noise Stress ◽  
Rat Pups

scholarly journals Age-dependent differences of treadmill exercise on spatial learning ability between young- and adult-age rats

2017 ◽  
Vol 13 (4) ◽  
pp. 381-386 ◽  
Author(s):  
Jun-Jang Jin ◽  
Il-Gyu Ko ◽  
Sung-Eun Kim ◽  
Lakkyong Hwang ◽  
Man-Gyoon Lee ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability ◽  
Adult Age ◽  
Age Dependent

scholarly journals Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy

2021 ◽  
Vol 17 (2) ◽  
pp. 88-95
Author(s):  
Tae-Woon Kim ◽  
Young Jun Ko ◽  
Ki-Hyok Youn ◽  
Boo-Geun Hwang ◽  
Hyun-Seok Bang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability

scholarly journals Environmental Enrichment Protects Offspring of Preeclamptic-Like Rat Model From Cognitive Decline

2021 ◽  
Author(s):  
Huiqing Lu ◽  
Lili Gong ◽  
Huangfang Xu ◽  
Qiongjie Zhou ◽  
Huanqiang Zhao ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Ability ◽  
Inflammatory Cytokines ◽  
Spatial Learning ◽  
Rat Model ◽  
Environmental Enrichment ◽  
Hippocampal Neurogenesis ◽  
Learning Ability ◽  
Expression Level ◽  
Apoptosis Level

Abstract Background: Preeclampsia affects 5-8% of all pregnancies and contributes to adverse pregnancy and birth outcome. In addition to short-term effects of preeclampsia, it can exert long-term adverse effects on offspring. Numerous studies has demonstrated that offspring of preeclamptic women exhibited cognitive deficit from childhood to old age. However, effective ways to improving their cognitive ability remains to be investigated. The aim of this study was to explore whether Environmental Enrichment in early life could restore cognitive ability of offspring of preeclampsia rat model, as well as cellular and molecular mechanism by which EE improve cognitive ability.Methods: L-NAME was used to establish preeclampsia rat model. The spatial learning and memory ability of 56-day-old offspring was evaluated by Morris Water Maze. Immunofluorescence was performed to evaluate cell proliferation and apoptosis in the DG region of hippocampus. qRT-PCR was performed to examine the expression level of neurogenesis-associated genes and inflammatory cytokines. Enzyme-linked immune absorbent assay was performed to evaluate the concentration of Vascular endothelial growth factor (VEGF) and inflammatory cytokines in the hippocampus.Results: The administration of L-NAME led to increased systolic blood pressure and urine protein level of pregnant rat. Offspring in L-NAME group exhibited impaired spatial learning ability and memory. The hippocampus neurogenesis and synaptic plasticity was impaired in offspring of L-NAME group. Furthermore, the cell apoptosis in hippocampus was increased in L-NAME group. The hippocampus was skewed to a pro-inflammatory profile, reflected by increased inflammatory cytokines level. While EE improved cognitive ability of offspring in L-NAME group and resulted in increased hippocampal neurogenesis and synaptic proteins expression level, decreased apoptosis level and inflammatory cytokines.Conclusions: Environment Enrichment resolves cognitive impairment in offspring of preeclampsia rat model by improving hippocampal neurogenesis and synaptic plasticity, normalizing the apoptosis level and the inflammation balance.

scholarly journals Treadmill exercise ameliorates disturbance of spatial learning ability in scopolamine-induced amnesia rats

2014 ◽  
Vol 10 (3) ◽  
pp. 155-161 ◽  
Author(s):  
Yu-Mi Heo ◽  
Mal-Soon Shin ◽  
Su-Hyun Kim ◽  
Tae-Wook Kim ◽  
Sang-Bin Baek ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability

scholarly journals Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats

2015 ◽  
Vol 11 (3) ◽  
pp. 133-139 ◽  
Author(s):  
Eun-Sang Ji ◽  
You-Mi Kim ◽  
Mal-Soon Shin ◽  
Chang-Ju Kim ◽  
Kwang-Sik Lee ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Spatial Learning ◽  
Treadmill Exercise ◽  
Learning Ability ◽  
Hippocampal Apoptosis
Sign in / Sign up

Export Citation Format

Share Document